Technology Process of [(1R)-2-(3-tert-butoxycarbonyl-2-methoxy-phenyl)-1-chloro-ethyl]boronic acid (-)-pinanediolato diester
There total 6 articles about [(1R)-2-(3-tert-butoxycarbonyl-2-methoxy-phenyl)-1-chloro-ethyl]boronic acid (-)-pinanediolato diester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
dichloromethane;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -100 ℃;
for 1h;
(3-tert-butoxycarbonyl-2-methoxy-phenyl)methylboronic acid (-)-pinanediolato diester;
With
zinc(II) chloride;
In
tetrahydrofuran; diethyl ether; hexane;
at -100 - -10 ℃;
for 1.13333h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 2,3-Dimethyl-2-butene; disodium hydrogen phosphate monohydrate; sodium chlorite / water; tert-butyl alcohol / 0.33 h
2.1: thionyl chloride / 0.5 h / 82 °C
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -5 °C
3.2: 1.5 h
4.1: TurboGrignard / tetrahydrofuran / 0.33 h / -40 °C
4.2: 0.75 h / -78 °C
4.3: 2 h
5.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -100 °C
5.2: 1.13 h / -100 - -10 °C
With
sodium chlorite; TurboGrignard; n-butyllithium; thionyl chloride; 2,3-Dimethyl-2-butene; disodium hydrogen phosphate monohydrate;
In
tetrahydrofuran; hexane; water; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: thionyl chloride / 0.5 h / 82 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -5 °C
2.2: 1.5 h
3.1: TurboGrignard / tetrahydrofuran / 0.33 h / -40 °C
3.2: 0.75 h / -78 °C
3.3: 2 h
4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -100 °C
4.2: 1.13 h / -100 - -10 °C
With
TurboGrignard; n-butyllithium; thionyl chloride;
In
tetrahydrofuran; hexane;
