4-(4-Methoxyphenyl)-2-methylbutan-2-ol

Base Information

• Chemical Name: 4-(4-Methoxyphenyl)-2-methylbutan-2-ol
• CAS No.: 14305-29-4
• Molecular Formula: C₁₂H₁₈O₂
• Molecular Weight: 194.274
• European Community (EC) Number: 889-560-2
• Nikkaji Number: J807.634K
• Mol file: 14305-29-4.mol

Synonyms:4-(4-methoxyphenyl)-2-methylbutan-2-ol;14305-29-4;SCHEMBL8939115;AKOS014316464;4-(p-methoxyphenyl)-2-methylbutan-2-ol;CS-0235728;EN300-160333;4-Methoxy-OE+/-,OE+/--dimethylbenzenepropanol

Chemical Property of 4-(4-Methoxyphenyl)-2-methylbutan-2-ol

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 194.130679813
• Heavy Atom Count: 14
• Complexity: 158

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(CCC1=CC=C(C=C1)OC)O

Technology Process of 4-(4-Methoxyphenyl)-2-methylbutan-2-ol

There total 25 articles about 4-(4-Methoxyphenyl)-2-methylbutan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-(4-methoxyphenyl)-2-butanone (104-20-1) + methylmagnesium chloride (676-58-4) → 3-hydroxy-1-(4-methoxyphenyl)-3-methylbutane (14305-29-4)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jacs.6b03157

Reference yield: 82.0%

methyl magnesium iodide (917-64-6) + methyl 3-(4-methoxyphenyl)propionate (15823-04-8) → 3-hydroxy-1-(4-methoxyphenyl)-3-methylbutane (14305-29-4)

Guidance literature:

In diethyl ether;

DOI:10.1134/S1070428006080045

Reference yield: 70.0%

ethyl (E)-3-(4-methoxyphenyl)prop-2-enoate (24393-56-4) + methylmagnesium bromide (75-16-1) → 3-hydroxy-1-(4-methoxyphenyl)-3-methylbutane (14305-29-4)

Guidance literature:

With palladium 10% on activated carbon; In diethyl ether; toluene; at 0 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.8b03299

upstream raw materials:

methyl magnesium iodide

4-(4-methoxyphenyl)-2-butanone

methylmagnesium bromide

2,2,2-trifluoroethanol

Downstream raw materials:

5-Methoxy-3,3-dimethyl-indane

1-methoxy-4-(3-methylbutyl)benzene

1,1-dimethyl-3-(4-methoxyphenyl)propylamine

3-chloro-1-(4-methoxyphenyl)-3-methylbutane