Chemical Property of Mannitol
Chemical Property:
- Appearance/Colour:White fine powder
- Vapor Pressure:7.22E-12mmHg at 25°C
- Melting Point:166-168oC
- Refractive Index:1.597
- Boiling Point:494.9 °C at 760 mmHg
- PKA:pKa 13.50(H2O,t =18)(Approximate)
- Flash Point:292.5 °C
- PSA：121.38000
- Density:1.596 g/cm3
- LogP:-3.58540
- Storage Temp.:Inert atmosphere,Room Temperature
- Water Solubility.:soluble
- XLogP3:-3.1
- Hydrogen Bond Donor Count:6
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:5
- Exact Mass:182.07903816
- Heavy Atom Count:12
- Complexity:105
- Purity/Quality:
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99.99%HPLC *data from raw suppliers
Mannitol Meets ACS Specifications GR ACS *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
S24/25:;
- MSDS Files:
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SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Chemical Classes:Biological Agents -> Monosaccharides and Derivatives
- Canonical SMILES:C(C(C(C(C(CO)O)O)O)O)O
- Isomeric SMILES:C([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O
- Recent ClinicalTrials:Efficacy of Sodium Thiosulfate and Mannitol in Reducing Ototoxicity in Adult Patients Receiving Cisplatin Chemotherapy
- Recent EU Clinical Trials:Efficacy and Safety of mAnniTol in bowel preparation: assessment of adequacy and presence of Intestinal levelS of hydrogen and methane during elective colonoscopy aFter mAnnitol or standard split 2-liter polyethylene glycol solution plus asCorbaTe – a phase II/III, International, multicentre, randomized, parallel-group, endoscOpist-bliNded, dose-finding/non-inferiority study - SATISFACTION
- Recent NIPH Clinical Trials:A phase 1 study in patients with Fukuyama-type congenital muscular dystrophy
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Description
It can be used to lower intraocular pressure and in the postoperational
period in ophthalomological procedures as well as during brain edema.
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Uses
Mannitol is a polyol (polyhydric alcohol) produced from hydrogena-
tion from fructose that functions as a sweetener, humectant, and
bulking agent. it has low hygroscopicity and poor oil solvency. it
has 1.6 kcal/g. it is approximately 22% soluble in water and is
approximately 72% as sweet as sugar, exhibiting a cool, sweet taste.
it functions as a dusting agent with starch in chewing gum. it is
used in sugarless candy, chewing gum, cereal, and pressed mints. Mannitol also known as wood mellow, is a kind of hexahydrin that can be used as a diuretic or sweetener.
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Clinical Use
Mannitol is the agent most commonly used as an osmotic diuretic. Sorbitol also can be used for similar reasons.Mannitol is administered intravenously in solutions of 5 to 50% at a rate of administration that is adjusted to maintain the urinary output at 30 to 50 ml/hour. Mannitol is filtered at the glomerulus and is poorly reabsorbed by the kidney tubule. The osmotic effect of mannitol in the tubule inhibits the reabsorption of water, and the rate of urine flow can be maintained. It also is used to reduce intracranial pressure by reducing cerebral intravascular volume.
