3-methoxy-α-methyl-benzenepropanal

Base Information

• Chemical Name: 3-methoxy-α-methyl-benzenepropanal
• CAS No.: 68383-30-2
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.231
• Mol file: 68383-30-2.mol

Synonyms:3-methoxy-α-methyl-benzenepropanal

Chemical Property of 3-methoxy-α-methyl-benzenepropanal

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 3-methoxy-α-methyl-benzenepropanal

There total 6 articles about 3-methoxy-α-methyl-benzenepropanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methylpropenal (78-85-3,25120-30-3) + methoxybenzene (100-66-3) → 3-methoxy-α-methyl-benzenepropanal (68383-30-2) + 3-(p-methoxyphenyl)-2-methylpropionaldehyde (5462-06-6) + 3-(o-Methoxyphenyl)-2-methylpropionaldehyde (246529-82-8)

Guidance literature:

2-methylpropenal; methoxybenzene; With oxygen; sodium acetate; acetylacetone; palladium diacetate; In propionic acid; at 70 ℃; for 4h; under 760.051 Torr;

With hydrogen; palladium on activated charcoal; under 760.051 Torr; Further stages.;

DOI:10.1021/jo050534o

Reference yield:

formic acid (64-18-6) + 1-allyl-3-methoxybenzene (24743-14-4) → 2-(3-methoxyphenyl)butyraldehyde (1024039-14-2) + 3-methoxy-α-methyl-benzenepropanal (68383-30-2) + 4-(3'-methoxyphenyl)butyraldehyde (91152-86-2)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; bis(1,5-cyclooctadiene)diiridium(I) dichloride; dicyclohexyl-carbodiimide; In acetonitrile; at 90 ℃; for 24h; Overall yield = 72 %; Overall yield = 64.3 mg; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.9b02047

Reference yield:

3-methoxyphenyl bromide (2398-37-0) + 3-hydroxy-2-methyl-1-propene (513-42-8) → 3-methoxy-α-methyl-benzenepropanal (68383-30-2)

Guidance literature:

With sodium hydrogencarbonate; triphenylphosphine; palladium dichloride; In N,N-dimethyl-formamide; at 130 ℃;

upstream raw materials:

3-methoxyphenyl bromide

3-hydroxy-2-methyl-1-propene

2-methylpropenal

methoxybenzene