1-carbomethoxy-2-methoxycyclohexane

Base Information

• Chemical Name: 1-carbomethoxy-2-methoxycyclohexane
• CAS No.: 51664-89-2
• Molecular Formula: C₉H₁₆O₃
• Molecular Weight: 172.224
• Mol file: 51664-89-2.mol

Synonyms:1-carbomethoxy-2-methoxycyclohexane

Chemical Property of 1-carbomethoxy-2-methoxycyclohexane

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1-carbomethoxy-2-methoxycyclohexane

There total 11 articles about 1-carbomethoxy-2-methoxycyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

[bis(acetoxy)iodo]benzene (3240-34-4) + ethyl cyclohexanecarboxylate (3289-28-9) + sodium methylate (124-41-4) → 1-carbomethoxy-2-methoxycyclohexane (51664-89-2)

Guidance literature:

In methanol; for 72h; Ambient temperature;

DOI:10.1016/S0040-4039(01)90541-6

Reference yield: 21.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 1-(acetoxymercurio)-2-methoxycyclohexane (51664-95-0) → 1-carbomethoxy-2-methoxycyclohexane (51664-89-2)

Guidance literature:

With Wilkinson's catalyst; at 65 - 100 ℃; under 5171.5 - 25857.4 Torr;

DOI:10.1021/jo00223a034

Reference yield:

2-methoxybenzoic acid methyl ester (606-45-1) → methyl cyclohexylcarboxylate (4630-82-4) + 1-carbomethoxy-2-methoxycyclohexane (51664-89-2)

Guidance literature:

With methanol; nickel; at 200 ℃; under 102971 - 139746 Torr; Hydrogenation;

DOI:10.1021/jo01199a008

upstream raw materials:

2-methoxybenzoic acid methyl ester

methyl cyclohex-1-ene-1-carboxylate

methanol

carbon monoxide

Downstream raw materials:

(+/-)-cis-2-methoxy-cyclohexanecarboxylic acid-(4-bromo-phenacyl ester)

(+/-)-cis-2-methoxy-cyclohexanecarboxylic acid amide

(+/-)-cis-2-methoxy-cyclohexanecarboxylic acid

Refernces

• 1、 Baird, William C.,Hartgerink, Ronald L.,Surridge, John H.. "Carbonylation of Organomercury Compounds: A General Synthesis of Carboxylic Acids and Esters". . p. 4601 - 4605. Retrieved 2007/10/02.