6-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid methyl ester

Base Information

Chemical Name:6-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid methyl ester
CAS No.:1364677-57-5
Molecular Formula:C₁₅H₁₁ClF₃NO₃
Molecular Weight:345.705
Hs Code.:

Synonyms:6-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid methyl ester

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Chemical Property of 6-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid methyl ester

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Technology Process of 6-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid methyl ester

There total 6 articles about 6-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 75-89-8
2,2,2-trifluoroethanol

: 201230-82-2
carbon monoxide

: 1233697-21-6
6-chloro-2-(4-chloro-phenyl)-3-fluoro-pyridine

: 1364677-57-5
6-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid methyl ester

Guidance literature:: 2,2,2-trifluoroethanol; With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 0.25h;

6-chloro-2-(4-chloro-phenyl)-3-fluoro-pyridine; In dimethyl sulfoxide; at 20 ℃; for 3h;

methanol; carbon monoxide; With triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; at 110 ℃; for 20h; under 52505.3 Torr;

Reference yield:

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 1364677-55-3
6-chloro-2-(4-chloro-phenyl)-3-(2,2,2-trifluoro-ethoxy)-pyridine

: 1364677-57-5
6-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid methyl ester

Guidance literature:: With triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; at 110 ℃; for 20h; under 52505.3 Torr;

Reference yield:

: 1679-18-1
4-Chlorophenylboronic acid

: 1364677-57-5
6-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; tetrahydrofuran / 18 h / 20 °C

2.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.25 h / 20 °C

2.2: 3 h / 20 °C

3.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 20 h / 110 °C / 52505.3 Torr

With sodium hydride; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water; dimethyl sulfoxide; mineral oil;