Methyl 2-acetamido-3-(4-methoxyphenyl)prop-2-enoate

Base Information

Chemical Name:Methyl 2-acetamido-3-(4-methoxyphenyl)prop-2-enoate
CAS No.:105962-56-9
Molecular Formula:C₁₃H₁₅NO₄
Molecular Weight:249.266
Hs Code.:
DSSTox Substance ID:DTXSID50699589
ChEMBL ID:CHEMBL4522398
Mol file:105962-56-9.mol

Synonyms:105962-56-9;Methyl 2-acetamido-3-(4-methoxyphenyl)prop-2-enoate;(Z)-METHYL 2-ACETAMIDO-3-(4-METHOXYPHENYL)ACRYLATE;CHEMBL4522398;DTXSID50699589

Suppliers and Price of Methyl 2-acetamido-3-(4-methoxyphenyl)prop-2-enoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Methyl 2-acetamido-3-(4-methoxyphenyl)prop-2-enoate

Chemical Property:

Melting Point:135 - 136 °C
PSA：68.12000
LogP:2.18550
XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:249.10010796
Heavy Atom Count:18
Complexity:330

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)NC(=CC1=CC=C(C=C1)OC)C(=O)OC

Technology Process of Methyl 2-acetamido-3-(4-methoxyphenyl)prop-2-enoate

There total 9 articles about Methyl 2-acetamido-3-(4-methoxyphenyl)prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 67-56-1
methanol

: 123-11-5
4-methoxy-benzaldehyde

: 543-24-8
N-acetylglycine

: 132165-61-8,105962-56-9
(Z)-methyl 2-acetamido-3-(4-methoxyphenyl)acrylate

Guidance literature:: N-acetylglycine; With chloroformic acid ethyl ester; triethylamine; In benzene; at 0 - 20 ℃;

4-methoxy-benzaldehyde; In benzene; at 80 ℃; for 2h;

methanol; With triethylamine; at 65 ℃; for 3h;
DOI:10.1039/d0ob00557f

Reference yield: 58.0%

: 35356-70-8
Methyl 2-acetamidoacrylate

: 66107-29-7
4-methoxyphenyl triflate

: 132165-61-8,105962-56-9
(Z)-methyl 2-acetamido-3-(4-methoxyphenyl)acrylate

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; tributyl-amine; lithium chloride; palladium diacetate; In N,N-dimethyl-formamide; at 80 ℃; for 24h;
DOI:10.1016/S0040-4020(01)87897-2