1-Boc-4-methoxypiperidine

Base Information

• Chemical Name: 1-Boc-4-methoxypiperidine
• CAS No.: 188622-27-7
• Molecular Formula: C11H21 N O3
• Molecular Weight: 215.293
• Hs Code.: 2933399090
• Mol file: 188622-27-7.mol

Synonyms:4-Methoxypiperidine-1-carboxylicacid tert-butyl ester; tert-Butyl 4-methoxy-1-piperidinecarboxylate

Chemical Property of 1-Boc-4-methoxypiperidine

Chemical Property:

• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.471
• Boiling Point: 274.1°Cat760mmHg
• Flash Point: 119.6°C
• PSA: 38.77000
• Density: 1.03g/cm³
• LogP: 1.97020

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-Methoxypiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-4-methoxypiperidine

There total 11 articles about 1-Boc-4-methoxypiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) + methyl iodide (74-88-4) → tert-butyl 4-methoxypiperidine-1-carboxylate (188622-27-7)

Guidance literature:

With sodium hydride; In DMF (N,N-dimethyl-formamide); for 0.5h;

Reference yield: 90.0%

4-methoxypiperidine (4045-24-3) + carbon monoxide (201230-82-2) + tert-butyl alcohol (75-65-0) → tert-butyl 4-methoxypiperidine-1-carboxylate (188622-27-7)

Guidance literature:

With 2C₇H₉N₄*Au⁽¹⁺⁾*Cu⁽¹⁺⁾*2I^(1-); In toluene; at 90 ℃; for 8h; Autoclave;

DOI:10.1002/anie.201914089

Reference yield: 83.0%

benzyl 4-methoxypiperidine-1-carboxylate (553672-12-1) + 2,2-dimethylpropanoic anhydride (1538-75-6) → tert-butyl 4-methoxypiperidine-1-carboxylate (188622-27-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 2.5h;

DOI:10.1021/acs.joc.7b00632

upstream raw materials:

t-butyl 4-hydroxy piperidine-1-carboxylate

methyl iodide

4-HYDROXYPIPERIDINE

di-tert-butyl dicarbonate

Downstream raw materials:

4-methoxypiperidine hydrochloride

N-tert-butyloxycarbonylpiperidin-4-one

1-((4-nitrophenyl)sulfonyl)piperidin-4-one

1-(2-amino-ethyl)-4-methoxypiperidine

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