(S)-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester

Base Information

• Chemical Name: (S)-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester
• CAS No.: 222556-21-0
• Molecular Formula: C₁₆H₂₈N₂O₆
• Molecular Weight: 344.408

Synonyms:(S)-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester

Chemical Property of (S)-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(S)-Tetrahydro-pyridazine-1,2,3-tricarboxylicacid1,2-di-tert-butylester3-methylester 97% ^*data from reagent suppliers

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Technology Process of (S)-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester

There total 7 articles about (S)-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(S)-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-(2,2,2-trichloro-ethyl) ester → (S)-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester (222556-21-0,174497-80-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 24h;

Reference yield: 96.0%

methanol (67-56-1) + (S)-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-(2,2,2-trichloro-ethyl) ester → (S)-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester (222556-21-0,174497-80-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 24h;

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + N,N'-di-tert-butoxycarbonylpiperazic acid (1219380-72-9) → methyl (3R)-N,N'-bis-(t-butoxycarbonyl)hexahydropyridazine-3-carboxylate (174497-80-4) + (S)-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester (222556-21-0,174497-80-4)

Guidance literature:

In diethyl ether; at 0 ℃; for 0.5h; Overall yield = 1.23 g;

DOI:10.1080/00397911.2014.947653

upstream raw materials:

diazomethane

(3S)-N,N'-bis-(t-butoxycarbonyl)hexahydropyridazine-3-carboxylic acid

(4S)-3-<(3S)-N,N'-bis(t-butoxycarbonyl)hexahydropyridazine-3-carboxy>-4-phenylmethyl-2-oxazolidinone

di-tert-butyl 3-[(S)-4-benzyl-2-oxo-1,3-oxazolidine-3-carbonyl]hexahydropyridazine-1,2-dicarboxylate

Downstream raw materials:

methyl (S)-hexahydropyridazine-3-carboxylate

(S)-1-[(S)-3-(3-Benzyloxy-phenyl)-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-propionyl]-hexahydro-pyridazine-3-carboxylic acid methyl ester

(tert-butoxycarbonyl)-L-phenylalanine-hexahydropyridazine-3S-carboxylic acid methyl ester

(tert-butoxycarbonyl)-L-valine-L-phenylalanine-hexahydropyridazine-3S-carboxylic asid methyl ester

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