N-methylpyridine-2-carboxamide

Base Information

• Chemical Name: N-methylpyridine-2-carboxamide
• CAS No.: 6144-78-1
• Molecular Formula: C7H8N2O
• Molecular Weight: 136.153
• Hs Code.: 2933399090
• European Community (EC) Number: 823-700-5
• ChEMBL ID: CHEMBL276719
• DSSTox Substance ID: DTXSID10483502
• Nikkaji Number: J1.902.233A
• Wikidata: Q82320869
• Mol file: 6144-78-1.mol

Synonyms:N-methylpicolinamide

Chemical Property of N-methylpyridine-2-carboxamide

Chemical Property:

• Boiling Point: 128 °C(Press: 12 Torr)
• PKA: 13.91±0.46(Predicted)
• PSA: 45.48000
• Density: 1.106±0.06 g/cm3(Predicted)
• LogP: 1.01600
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 136.063662883
• Heavy Atom Count: 10
• Complexity: 125

Purity/Quality:

≥99% ^*data from raw suppliers

N-MethylPicolinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC(=O)C1=CC=CC=N1
• Uses: N-Substituted picolinamides as drowsiness-free central muscle relaxants.

Technology Process of N-methylpyridine-2-carboxamide

There total 1 articles about N-methylpyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

pyridine N-oxide (694-59-7) + N-Methylformamide (123-39-7) → pyridine (110-86-1) + N-methylpyridine-2-carboxamide (6144-78-1) + N-methylisonicotinamide (6843-37-4)

Guidance literature:

for 120h; Heating;

Reference yield: 71.0%

1-methyl-1H-imidazole (616-47-7) + N-methylpyridine-2-carboxamide (6144-78-1) + rhenium(I) pentacarbonyl bromide (14220-21-4) + silver trifluoromethanesulfonate (2923-28-6) + sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate (79060-88-1) → silver(I) bromide + [Re(CO)3(N-methylimidazole)2(N-methylnicotinamide)]B(3,5-bis(trifluoromethyl)phenyl)4 + sodium triflate (2926-30-9)

Guidance literature:

In dichloromethane; toluene; (N2); imdazole was added to soln. of ReBr(CO)5 in toluene, refluxed for 30 min, evapd. in vac., dissolved in CH2Cl2, AgOTf was added, stirred inthe dark for 1 h, filtered through celite, NaBAr'4 and pyridine were ad ded, stirred for 1 h; filtered, concd., precipitated with hexane, washed with hexane, elem. anal.;

DOI:10.1021/ic201120s

Reference yield: 50.0%

N-methylpyridine-2-carboxamide (6144-78-1) + (2′,6′-dimethoxybiphenyl-2-yl)phenylphosphine chloride → C27H25N2O3P

Guidance literature:

N-methylpyridine-2-carboxamide; With n-butyllithium; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

(2′,6′-dimethoxybiphenyl-2-yl)phenylphosphine chloride; In tetrahydrofuran; at 0 - 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.inorgchem.1c01490

upstream raw materials:

pyridine N-oxide

N-Methylformamide

Downstream raw materials:

3-(Hydroxy-diphenyl-methyl)-pyridine-2-carboxylic acid methylamide

3-(Hydroxy-p-tolyl-methyl)-pyridine-2-carboxylic acid methylamide

3-[Hydroxy-(4-methoxy-phenyl)-methyl]-pyridine-2-carboxylic acid methylamide

1-Hydroxy-2-methyl-1-phenyl-pyrro<3,4-b>pyridine-3(1H)-one