4-(4-Methoxy-phenyl)-6-phenyl-pyrimidin-2-ol

Base Information

• Chemical Name: 4-(4-Methoxy-phenyl)-6-phenyl-pyrimidin-2-ol
• CAS No.: 24030-09-9
• Molecular Formula: C17H14N2O2
• Molecular Weight: 278.31
• DSSTox Substance ID: DTXSID401240906
• Nikkaji Number: J530.437G
• ChEMBL ID: CHEMBL1328333
• Mol file: 24030-09-9.mol

Synonyms:CBMicro_014074;Cambridge id 5213237;4-(4-Methoxy-phenyl)-6-phenyl-pyrimidin-2-ol;Oprea1_309378;Oprea1_376036;MLS000123194;CHEMBL1328333;DTXSID401240906;HMS2751C18;SMSF0004567;CB09002;SMR000123758;BIM-0014034.P001;AB00075417-01;4-(4-Methoxyphenyl)-6-phenyl-2(1H)-pyrimidinone;4-(p-methoxy-phenyl)-6-phenyl-pyrimidin-2(1h)-one;4-Phenyl-6-(4-methoxyphenyl)-2(1H)-pyrimidinone;4-(4-Methoxyphenyl)-6-phenyl-2(1H)-pyrimidinone #;2-Oxo-4-phenyl-6-(4-methoxyphenyl)-1,2-dihydropyrimidine;24030-09-9

Chemical Property of 4-(4-Methoxy-phenyl)-6-phenyl-pyrimidin-2-ol

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 278.105527694
• Heavy Atom Count: 21
• Complexity: 442

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=CC(=NC(=O)N2)C3=CC=CC=C3

Technology Process of 4-(4-Methoxy-phenyl)-6-phenyl-pyrimidin-2-ol

There total 10 articles about 4-(4-Methoxy-phenyl)-6-phenyl-pyrimidin-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-methoxy-benzaldehyde (123-11-5) + acetophenone (98-86-2) + urea (57-13-6) → 4-(p-methoxy-phenyl)-6-phenyl-pyrimidin-2(1H)-one (24030-09-9)

Guidance literature:

With iodine; at 80 ℃; for 0.0833333h;

DOI:10.1080/00397911.2010.493263

Reference yield: 96.0%

4-methoxy-benzaldehyde (123-11-5) + acetophenone (98-86-2) + urea (57-13-6) → 6-(4-methoxyphenyl)-4-phenyl-2-oxo-1,2-dihydropyrimidine (24030-09-9)

Guidance literature:

With 1-methyl-2-oxopyrrolidinium hydrogen sulfate; In neat (no solvent); at 70 ℃; for 0.0333333h; Reagent/catalyst; Green chemistry;

Reference yield: 91.0%

benzaldehyde (100-52-7) + urea (57-13-6) + 1-(4-methoxyphenyl)ethanone (100-06-1) → 6-(4-methoxyphenyl)-4-phenyl-2-oxo-1,2-dihydropyrimidine (24030-09-9)

Guidance literature:

With 1,3,5-trichloro-2,4,6-triazine; zinc trifluoromethanesulfonate; for 0.2h; microwave irradiation;

DOI:10.3987/COM-05-10613

upstream raw materials:

4-methoxy-benzaldehyde

acetophenone

urea

benzaldehyde