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Spermine

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Name

Spermine

EINECS 200-754-2
CAS No. 71-44-3 Density 0.925 g/cm3
PSA 76.10000 LogP 1.82580
Solubility 1 M at 20 °C, clear, colorless Melting Point 310-311 °C (dec.)(lit.)
Formula C10H26N4 Boiling Point 308.4 °C at 760 mmHg
Molecular Weight 202.40 Flash Point 175.6 °C
Transport Information UN 3259 8/PG 2 Appearance white to slightly off-white powder crystal
Safety 26-36-45-36/37/39-27 Risk Codes 36/38-34
Molecular Structure Molecular Structure of 71-44-3 (Diaminopropyltetramethylenediamine) Hazard Symbols IrritantXi,CorrosiveC
Synonyms

1,4-Butanediamine,N,N'-bis(3-aminopropyl)- (8CI,9CI);Spermine (6CI);1,5,10,14-Tetraazatetradecane;4,9-Diazadodecane-1,12-diamine;Gerontine;Musculamine;N,N'-Bis(3-aminopropyl)-1,4-butanediamine;N,N'-Bis(3-aminopropyl)-1,4-tetramethylenediamine;NSC 268508;Neuridine;

 

Spermine Synthetic route

14209-32-6

3-(4-[(2-cyanoethyl)amino]butylamino)propanenitrile

71-44-3

Spermine

Conditions
ConditionsYield
With sodium; butan-1-ol
With diethyl ether; ammonia; nickel at 140℃; under 250073 Torr; Hydrogenation;
With hydrogenchloride; platinum Hydrogenation;
78706-92-0

1,2-bis(1,4,5,6-tetrahydropyrimidin-2-yl)ethane

71-44-3

Spermine

Conditions
ConditionsYield
With sulfuric acid; diisobutylaluminium hydride; 1,1,1,3,3,3-hexamethyl-disilazane 1.) reflux, 12 h, 2.) xylene, reflux, 3 d; Yield given. Multistep reaction;
525-79-1

kinetin

A

124-20-9

N-(3-aminopropyl)-1,4-diaminobutane

B

71-44-3

Spermine

C

110-60-1

1,4-diaminobutane

Conditions
ConditionsYield
at 30℃; for 24h; effect on poliamine content and ratio in rice embryos of Oryza sativa;
14398-53-9

(R)-(-)-abscisic acid

A

124-20-9

N-(3-aminopropyl)-1,4-diaminobutane

B

71-44-3

Spermine

C

110-60-1

1,4-diaminobutane

Conditions
ConditionsYield
at 30℃; for 24h; effect on poliamine content and ratio in rice embryos of Oryza sativa;
12651-38-6

(-)-Verbaskine

A

71-44-3

Spermine

B

140-10-3

(E)-3-phenylacrylic acid

Conditions
ConditionsYield
With hydrogenchloride at 150℃; for 18h; sealed tube;
73397-39-4

1-(4-Amino-butyl)-tetrahydro-pyrimidin-2-one

107-13-1

acrylonitrile

71-44-3

Spermine

Conditions
ConditionsYield
Yield given. Multistep reaction;
77485-28-0

N'-(4-(N'-hexahydropyrimidyl) butyl)-hexahydro-pyrimidine

A

50-00-0

formaldehyd

B

71-44-3

Spermine

Conditions
ConditionsYield
With hydrogenchloride Heating;
185250-13-9

1,1'-(butane-1,4-diyl)-2,2'-diphenylbis(hexahydropyrimidine)

A

71-44-3

Spermine

B

100-52-7

benzaldehyde

Conditions
ConditionsYield
With hydrogenchloride at 20℃;
1.4-bis-<γ-bromo-propylamino>-butane dihydrobromide

1.4-bis-<γ-bromo-propylamino>-butane dihydrobromide

71-44-3

Spermine

Conditions
ConditionsYield
With ethanol; ammonia at 100℃;
110-60-1

1,4-diaminobutane

N-<γ-iodo-propyl>-phthalimide

N-<γ-iodo-propyl>-phthalimide

71-44-3

Spermine

Conditions
ConditionsYield
at 100℃; anschl. mit wss. KOH, anschl. Erhitzen mit HCl auf 100grad;

N,N'-Bis(3-brompropyl)-1,4-diaminobutan

potassium-

potassium-

71-44-3

Spermine

Conditions
ConditionsYield
With pentan-1-ol Erwaermen des Reaktionsprodukts mit Hydrazin-hydrat in Aethanol;

(Z)-1-{N-[3-aminopropyl]-N-[4-(3-aminopropyl-ammonio)butyl]-amino}-diazen-1-ium-1,2-diolate

71-44-3

Spermine

Conditions
ConditionsYield
With sodium hydroxide; phosphate buffer at 37℃; pH=5.60 - 8.50; Kinetics; Further Variations:; pH-values;
477808-25-6

3,10-dioxo-4,9-diazadodecanediamide

71-44-3

Spermine

Conditions
ConditionsYield
With borane-THF In tetrahydrofuran for 7h; Heating;
477808-23-4

N-[4-(2-methoxycarbonyl-acetylamino)-butyl]-malonamic acid methyl ester

71-44-3

Spermine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NH3 / methanol / 7 °C
2: BH3*THF / tetrahydrofuran / 7 h / Heating
View Scheme
78707-11-6

C24H30N4O4S2

71-44-3

Spermine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 97 percent / sodium methoxide / methanol / 0.33 h / 0 °C
2: 1.) hexamethyldisilazane, fuming sulfuric acid, 2.) diisobutylaluminum hydride / 1.) reflux, 12 h, 2.) xylene, reflux, 3 d
View Scheme
124-20-9

N-(3-aminopropyl)-1,4-diaminobutane

71-44-3

Spermine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2) Ba(OH)2
View Scheme

N-(3-aminopropyl)-N'-(3-ethylaminopropyl)butane-1,4-diamine

A

124-20-9

N-(3-aminopropyl)-1,4-diaminobutane

B

71-44-3

Spermine

C

10563-23-2

N-ethyl-1,3-diaminopropane

D

N1-(3-ethylaminopropyl)butane-1,4-diamine

Conditions
ConditionsYield
With recombinant human polyamine oxidase pH=9.5; Kinetics; pH-value; Reagent/catalyst; Enzymatic reaction;

N1-(3-aminopropyl)-N4-(3-(benzylamino)propyl)butane-1,4-diamine

A

124-20-9

N-(3-aminopropyl)-1,4-diaminobutane

B

71-44-3

Spermine

C

100-46-9

benzylamine

D

N-{3-[(4-aminobutyl)amino]propyl}(phenylmethyl)amine

Conditions
ConditionsYield
With recombinant human polyamine oxidase pH=9.5; Kinetics; pH-value; Reagent/catalyst; Enzymatic reaction;
1111644-29-1

N-(3-benzylaminopropyl)-N'-(3-ethylaminopropyl)butane-1,4-diamine

A

124-20-9

N-(3-aminopropyl)-1,4-diaminobutane

B

71-44-3

Spermine

C

10563-23-2

N-ethyl-1,3-diaminopropane

D

N1-(3-ethylaminopropyl)butane-1,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: spermine oxidase / pH 9.5 / Enzymatic reaction
2: recombinant human polyamine oxidase / pH 9.5 / Enzymatic reaction
View Scheme
Multi-step reaction with 2 steps
1: recombinant human polyamine oxidase / pH 9.5 / Enzymatic reaction
2: recombinant human polyamine oxidase / pH 9.5 / Enzymatic reaction
View Scheme
117654-79-2

1,14-bis(phenylmethyl)-1,5,10,14-tetraazatetradecane tetrahydrochloride

A

124-20-9

N-(3-aminopropyl)-1,4-diaminobutane

B

71-44-3

Spermine

C

100-46-9

benzylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: recombinant human polyamine oxidase / pH 9.5 / Enzymatic reaction
2: recombinant human polyamine oxidase / pH 9.5 / Enzymatic reaction
View Scheme
124-20-9

N-(3-aminopropyl)-1,4-diaminobutane

C15H25N6O3S(1+)

A

71-44-3

Spermine

B

5'-methylthioadenosine

Conditions
ConditionsYield
With Thermus thermophilus triamine/agmatine aminopropyltransferase; diothiothreitol at 37℃; pH=9; Kinetics; aq. buffer; Enzymatic reaction;

3,3′,3″,3′″-(butane-1,4-diylbis(azanetriyl))tetrapropanenitrile

A

71-44-3

Spermine

B

120239-63-6

N,N,N',N'-tetra(3-aminopropyl)-1,4-butanediamine

C

N,N,N'-tris(3-aminopropyl)-1,4-butanediamine

Conditions
ConditionsYield
With ammonia; hydrogen In tetrahydrofuran at 50℃; under 33753.4 Torr; Autoclave;

C32H48N6O12S2

71-44-3

Spermine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: thionyl chloride; methanol / 2 h / 0 - 20 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine; dmap / N,N-dimethyl-formamide / 24 h / 20 °C
2.2: 24 h / 0 - 20 °C / Inert atmosphere
View Scheme

C22H32N6O8S2

71-44-3

Spermine

Conditions
ConditionsYield
Stage #1: C22H32N6O8S2 With dmap; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 24h;
Stage #2: With 1,8-diazabicyclo[5.4.0]undec-7-ene; 2-hydroxyethanethiol In N,N-dimethyl-formamide at 0 - 20℃; for 24h; Inert atmosphere;
Stage #3: With trifluoroacetic acid In dichloromethane
30 mg
71-44-3

Spermine

22509-74-6

N-ethoxycarbonylphthalimide

104435-59-8

1,12-diphthalimido-4,9-diazadodecane

Conditions
ConditionsYield
In chloroform at 20℃; for 1h;100%
In dichloromethane Ambient temperature;86%
In chloroform Ambient temperature;70%
71-44-3

Spermine

63867-00-5

3-(4'-acetoxyphenyl)propionyl chloride

N1,N5,N10,N14-tertakis[3-(4-acetoxyphenyl)propanoyl]-1,5,10,14-tetraazatetradecane

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃;100%
1477-49-2

3-indolylglyoxylic acid

71-44-3

Spermine

76-05-1

trifluoroacetic acid

N1,N4-bis(3-(2-(1H-indol-3-yl)-2-oxoacetamido)propyl)butane-1,4-diaminium 2,2,2-trifluoroacetate

Conditions
ConditionsYield
Stage #1: 3-indolylglyoxylic acid; Spermine With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃; for 23h; Inert atmosphere;
Stage #2: trifluoroacetic acid In methanol; water
100%
71-44-3

Spermine

13710-19-5

tolfenamic Acid

tolfenamic acid spermine salt

Conditions
ConditionsYield
In methanol at 20℃; for 0.5h;99%
71-44-3

Spermine

C10H26N6O2

Conditions
ConditionsYield
With nitrogen(II) oxide In acetonitrile under 3800 Torr; for 20h; Ambient temperature;98%
71-44-3

Spermine

383-63-1

ethyl trifluoroacetate,

168788-09-8

N1,N12-di(trifluoroacetyl)-1,12-diamino-4,9-diazadodecane

Conditions
ConditionsYield
With water In methanol Heating;98%
In water; acetonitrile at 100℃;95%
In water; acetonitrile94%
71-44-3

Spermine

402598-52-1

(E)-3-(4-hydroxyphenyl)-2-methyl-2-propenoyl chloride

402598-61-2

N1,N5,N10,N14-tertakis[3-(4-acetoxyphenyl)-2-methyl-2-propenoyl]-1,5,10,14-tetraazatetradecane

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃;98%
71-44-3

Spermine

16308-68-2

allyl phenyl carbonate

N1,N8-bis(allyloxycarbonyl)spermine

Conditions
ConditionsYield
In dichloromethane at 20℃;98%
71-44-3

Spermine

110-17-8

(2E)-but-2-enedioic acid

spermine fumarate

Conditions
ConditionsYield
In water for 0.25h;98%
71-44-3

Spermine

244639-79-0

9-(5-O-dimethoxytrityl-2-deoxy-β-D-erythro-pentofuranose)-6-(1,2,4-triazol-4-yl)purine

259141-08-7

5'-O-dimethoxytrityl-6-N-(4,9,13-triazatridecane-1-yl)-2'-deoxyadenosine

Conditions
ConditionsYield
With pyridine at 70℃; for 8h; Substitution;97%
In pyridine at 70℃; Substitution;
71-44-3

Spermine

1114539-81-9

succinimidyl (E)-3-(trioxsalen-4'-yl)propenoate

N1,N12-bis[(E)-3-(trioxsalen-4'-yl)propenoyl]spermine bishydroxysuccinimidate salt

Conditions
ConditionsYield
In dichloromethane at 25℃; for 1h;96%
50-00-0

formaldehyd

71-44-3

Spermine

77485-28-0

N'-(4-(N'-hexahydropyrimidyl) butyl)-hexahydro-pyrimidine

Conditions
ConditionsYield
In water at 0℃; for 0.833333h;95%
In water at 20℃; for 20h;
71-44-3

Spermine

100-52-7

benzaldehyde

185250-13-9

1,1'-(butane-1,4-diyl)-2,2'-diphenylbis(hexahydropyrimidine)

Conditions
ConditionsYield
With potassium carbonate In dichloromethane at -78 - 23℃;95%
In benzene Heating;
71-44-3

Spermine

383-63-1

ethyl trifluoroacetate,

24424-99-5

di-tert-butyl dicarbonate

201984-66-9

1-trifluoroacetyl-5,10,14-tris-Boc-spermine

Conditions
ConditionsYield
Stage #1: Spermine; ethyl trifluoroacetate, In methanol at -78 - 0℃; for 1h;
Stage #2: di-tert-butyl dicarbonate In methanol at 0 - 25℃; for 15h;
95%
Stage #1: Spermine; ethyl trifluoroacetate, In methanol at -78 - 4℃; Inert atmosphere;
Stage #2: di-tert-butyl dicarbonate In methanol at 4℃; Inert atmosphere;
82.9%
Stage #1: Spermine; ethyl trifluoroacetate, In methanol at -78℃; for 1h; Inert atmosphere;
Stage #2: di-tert-butyl dicarbonate In methanol at 0 - 25℃; for 24h; Inert atmosphere;
49%
1) MeOH, 78 deg C, 1 h then 0 deg C, 1 h, 2) MeOH, 0 to 25 deg C, 1 h; Multistep reaction;
Stage #1: Spermine; ethyl trifluoroacetate, In methanol at -78 - 0℃; Inert atmosphere;
Stage #2: di-tert-butyl dicarbonate In methanol at 0 - 20℃; for 18h; Inert atmosphere;
71-44-3

Spermine

566-88-1

dihydrocholesterone

177745-14-1

3β-(12-amino-4,9-diaza-dodecyl)amino-cholestane

Conditions
ConditionsYield
Stage #1: Spermine; dihydrocholesterone With titanium(IV) isopropylate In methanol at 20℃; for 12h;
Stage #2: With sodium tetrahydroborate In methanol at -78℃; for 2h; Further stages.;
95%
71-44-3

Spermine

383-63-1

ethyl trifluoroacetate,

N1,N14-bis(trifluoroacetyl)spermine ditrifluoroacetate

Conditions
ConditionsYield
In water; acetonitrile Heating;94%
With water In acetonitrile Heating;93%
In acetonitrile Reflux;93%
With water In acetonitrile Reflux;93%
With water In acetonitrile Reflux;
71-44-3

Spermine

5-benzoyl-3-(cyclopent-1-en-1-yl)-5-phenyl-1,5-dihydro-4H-pyrazol-4-one

220221-33-0

C17H30N4O

Conditions
ConditionsYield
In dichloromethane at 20℃; for 0.5h; regioselective reaction;93%
71-44-3

Spermine

76-05-1

trifluoroacetic acid

501-52-0

3-Phenylpropionic acid

N1,N4-bis(3-(3-phenylpropanamido)propyl)butane-1,4-diaminium 2,2,2-trifluoroacetate

Conditions
ConditionsYield
Stage #1: Spermine; 3-Phenylpropionic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃; for 23h; Inert atmosphere;
Stage #2: trifluoroacetic acid In N,N-dimethyl-formamide Inert atmosphere;
92%
613-90-1

benzoyl cyanide

71-44-3

Spermine

111574-87-9

N1,N12-dibenzoylspermine

Conditions
ConditionsYield
In dichloromethane at 20℃; for 3h;91%
In dichloromethane for 15h; Ambient temperature;91%
In dichloromethane Ambient temperature;91%
71-44-3

Spermine

358-23-6

trifluoromethylsulfonic anhydride

144534-70-3

C,C,C-Trifluoro-N-(3-trifluoromethanesulfonylamino-propyl)-N-{4-[trifluoromethanesulfonyl-(3-trifluoromethanesulfonylamino-propyl)-amino]-butyl}-methanesulfonamide

Conditions
ConditionsYield
With triethylamine In dichloromethane for 1h; Ambient temperature; -30 deg C up to r.t.;90%
71-44-3

Spermine

2212-69-3

N2-benzyloxycarbonyl-N6-t-butoxycarbonyl-L-lysine 4-nitrophenyl ester

199340-70-0

((S)-5-{3-[4-(3-Amino-propylamino)-butylamino]-propylcarbamoyl}-5-benzyloxycarbonylamino-pentyl)-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 2.5h; Ambient temperature;90%
54888-42-5

2,2-diphenyl-benzo[1,3]dioxole-4-carbonyl chloride

71-44-3

Spermine

C90H74N4O12

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 50℃;90%
71-44-3

Spermine

10381-82-5

8-bromocaffeine

8-(3-(4-(3-aminopropylamino)butylamino)propylamino)caffeine

Conditions
ConditionsYield
In ethanol for 40h; Reflux;90%
In ethanol
71-44-3

Spermine

125802-80-4

(E)-3-(4-Nitro-phenyl)-acrylic acid 2,5-dioxo-pyrrolidin-1-yl ester

(E)-3-(4-Nitro-phenyl)-N-[3-(4-{3-[(E)-3-(4-nitro-phenyl)-acryloylamino]-propylamino}-butylamino)-propyl]-acrylamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃;89%
71-44-3

Spermine

2094-72-6

1-Adamantanecarbonyl chloride

C54H82N4O4

Conditions
ConditionsYield
With sodium hydroxide In dichloromethane88%
71-44-3

Spermine

383-63-1

ethyl trifluoroacetate,

2,2,2-trifluoro-N-(3-{4-[3-(2,2,2-trifluoro-acetylamino)-propylamino]-butylamino}-propyl)-acetamide trifluoroacetate

Conditions
ConditionsYield
With water In acetonitrile for 18h; Heating / reflux;88%
71-44-3

Spermine

22509-74-6

N-ethoxycarbonylphthalimide

N-(12-phthalimido-4,9-diazadodecyl)phthalimide*2HCl

Conditions
ConditionsYield
In tetrahydrofuran at 23℃; for 2h;87%
71-44-3

Spermine

82592-68-5, 98631-72-2

(E)-3,4-di-O-acetylcaffeoyl chloride

N1,N5,N10,N14-tertakis[3-(3,4-diacetoxyphenyl)-2-propenoyl]-1,5,10,14-tetraazatetradecane

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃;87%
71-44-3

Spermine

24424-99-5

di-tert-butyl dicarbonate

177213-61-5

di-tert-butyl butane-1,4-diylbis((3-aminopropyl)carbamate)

Conditions
ConditionsYield
Stage #1: Spermine With ethyl trifluoroacetate, In methanol at 0℃; for 0.5h;
Stage #2: di-tert-butyl dicarbonate In methanol at 20℃;
Stage #3: With sodium hydroxide In methanol at 20℃; for 4h;
87%
Stage #1: Spermine With ethyl trifluoroacetate, In methanol at -78℃; for 16h;
Stage #2: di-tert-butyl dicarbonate In dichloromethane at 20℃; for 12h;
Stage #3: With sodium hydroxide In methanol at 20℃; for 12h;
71-44-3

Spermine

C10H22Cl2N7P3

Conditions
ConditionsYield
With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine In chloroform for 48h; Ambient temperature;86.3%
With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine In chloroform at 20℃; Inert atmosphere;
With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine In chloroform at 20℃; Inert atmosphere;

Spermine Chemical Properties

Product Name: Diaminopropyltetramethylenediamine (CAS NO.71-44-3)

Empirical Formula: C10H26N4
Molecular Weight: 202.3402 
EINECS: 206-189-8
Melting point: 310-311 °C (dec.)(lit.)
Appearance: Clear colorless liquid
Storage temp.: 2-8°C
Solubility: H2O: 1 M at 20 °C, clear, colorless
Form: Powder
Sensitive: Air Sensitive & Hygroscopic
Stable: Stable. Reacts with water.
Index of Refraction: 1.484
Density: 0.925 g/cm3
Flash Point: 175.6 °C
Enthalpy of Vaporization: 54.91 kJ/mol
Boiling Point: 308.4 °C at 760 mmHg
Vapour Pressure: 0.000683 mmHg at 25 °C
Surface Tension: 38.3 dyne/cm
Index of Refraction: 1.484 
Molar Refractivity: 62.63 cm3 
Molar Volume: 218.5 cm3 
XLogP3-AA: -1.1
H-Bond Donor: 4
H-Bond Acceptor: 4
Structure Descriptors of Diaminopropyltetramethylenediamine (CAS NO.71-44-3):
  IUPAC Name: N,N'-bis(3-aminopropyl)butane-1,4-diamine
  Canonical SMILES: C(CCNCCCN)CNCCCN
  InChI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 
  InChIKey: PFNFFQXMRSDOHW-UHFFFAOYSA-N          
Product Categories: Aliphatics; Amines

Spermine Uses

 Diaminopropyltetramethylenediamine (CAS NO.71-44-3) can be used as an organic phosphorus pesticide intermediats. At the same time, it is a typical anionic surfactant with good penetration, emulsification, foam and decontamination capabilities, so it is widely used in chemical, pesticide, fiber, electric crossing, mineral and other industries, especiallily for cosmetics, toothpaste, shampoo and other manufacturings. In the textile industry, it is used for washing wool and silk.

Spermine Production

Take coconut oil as the raw material and then with Sulfuric acid by sulfonation to get: Diaminopropyltetramethylenediamine (CAS NO.71-44-3).

Spermine Toxicity Data With Reference

1.    

mmo-sat 100 µmol/L

    AMACCQ    Antimicrobial Agents and Chemotherapy. 9 (1976),77.
2.    

cyt-hmn:hla 2 mmol/L

    JCLLAX    Journal of Cellular Physiology. 78 (1971),217.
3.    

dni-rat:lvr 100 µmol/L

    BIJOAK    Biochemical Journal. 146 (1975),697.
4.    

ipr-rat LD50:33 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 88 (1987),433.
5.    

ivn-rat LD50:65 mg/kg

    AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 165 (1967),374.
6.    

orl-mus LD30:650 mg/kg

    AGACBH    Agents and Actions, A Swiss Journal of Pharmacology. 14 (1984),228.
7.    

ipr-mus LDLo:8 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 23 (1972),288.
8.    

scu-mus LD30:280 mg/kg

    AGACBH    Agents and Actions, A Swiss Journal of Pharmacology. 14 (1984),228.
9.    

ivn-mus LD50:56 mg/kg

    CSLNX*    U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) NX#00641 .

Spermine Consensus Reports

Reported in EPA TSCA Inventory.

Spermine Safety Profile

Poison by intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also AMINES.
Safety Information of Diaminopropyltetramethylenediamine (CAS NO.71-44-3):
Hazard Codes: IrritantXi,CorrosiveC
Risk Statements: 36/38-34 
R34:Causes burns. 
R36/38:Irritating to eyes and skin.
Safety Statements: 26-36-45-36/37/39-27 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S27:Take off immediately all contaminated clothing. 
S36:Wear suitable protective clothing. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

Spermine Specification

 Diaminopropyltetramethylenediamine , its cas register number is 71-44-3. It also can be called N,N'-Bis(3-aminopropyl)-1,4-butandiamin ; N,N'-Bis(3-aminopropyl)tetramethylenediamine ; 4,9-Diazadodecamethylenediamine ; and 1,4-Butanediamine, N1,N4-bis(3-aminopropyl)- .

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