Perform a selective deoxygenation reaction to remove the 3-hydroxy group from the ribose ring. This can be achieved by using reagents like phosphorus tribromide (PBr3) or thionyl chloride (SOCl2) to convert the hydroxyl group to a chloride, followed by substitution of the chloride with fluorine using an appropriate fluoride source, such as cesium fluoride (CsF) or diethylaminosulfur trifluoride (DAST).
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