Ligand Screening

Characterization Steric hindrance Optimization Ligand Design Mechanistic Studies Stereochemistry Control Solvent Effects Substrate Design Coordination Chemistry Catalyst Selection Product Analysis Catalyst Loading Ligand Synthesis Optimization of Reaction Conditions In-situ Formation of Catalyst Analytical Techniques Chiral Auxiliary Strategies Post-synthesis Manipulations Literature Search Chiral Bases Bifunctional Catalysts Temperature Control In Situ Activation Protection of Amine Group Chiral Pocket Formation Catalyst Tuning Selection of Amino Acid Precursor Sulfinamide Formation Transfer Hydrogenation Catalyst Enantioselective Transfer Hydrogenation Comparison with Existing Ligands