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Radiolabeling

A suitable radionuclide is chosen for radiolabeling. Common radionuclides used in PET imaging include carbon-11 (11C) and fluorine-18 (18F). The radiolabeling process must be efficient and produce a stable radiotracer.

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Articles of Radiolabeling

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Synthesis Evaluation Scanning electron microscopy (SEM) Transmission electron microscopy (TEM) Nuclear magnetic resonance (NMR) spectroscopy Optimization binding affinity Chemical modification Purification Data Analysis Ligand Design In vitro Testing Clinical Trials In Vivo Testing Biological Evaluation Safety and Toxicity Assessment In Vivo Studies Lead Compound Selection Regulatory Approval Pharmacokinetics PET Imaging Formulation Quality Control Preclinical Testing Target Identification and Validation Target Selection and Validation Chemical Synthesis of Radiotracers Radiotracer Optimization Radiosynthesis Optimization PET Imaging Studies In Vivo Imaging In Vitro Studies Identification of Target Receptor Click Chemistry-Based REM Linker Synthesis of Candidate Ligand In Vitro Binding Studies Human Studies Benzofuran Derivatives Targeting β-Amyloid Plaques Imaging and Diagnosis Future Research Biological Studies Selection of the Precursor Molecule Data Analysis and Interpretation Choice of Precursor Molecule Radiosynthesis Fluorescence Microscopy Confocal Microscopy Flow Cytometry Inductively Coupled Plasma Mass Spectrometry (ICP-MS)