After obtaining the protected phosphonate isostere, it can be incorporated into a growing peptide chain on a solid support (usually resin beads). This process involves the use of various coupling reagents, deprotection steps, and repetitive cycles to elongate the peptide chain in a controlled and stepwise manner.
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dibenzyl (E)-1-propenylphosphonate
(2S,3R)-2-Allyloxycarbonylamino-3-(4-benzyloxy-3-chloro-phenyl)-3-hydroxy-propionic acid
Silanol, (1,1-dimethylethyl)(3-nitrophenyl)phenyl-
N2-[(Benzyloxy)carbonyl]-L-glutamine 2,4,5-trichlorophenyl ester
L-Phenylalanine, N-(2,6-dimethoxybenzoyl)-L-valyl-, methyl ester
2,5-Pyrrolidinedione, 1-[[[2-(2,4-dinitrophenyl)ethoxy]carbonyl]oxy]-
(4S)-3-((3S)-6-hydroxy-3-phenylhexanoyl)-4-benzyl-1,3-oxazolidin-2-one
γ-benzyl<α-2H>glutamate
2-benzyl-3-hydroxyphosphinoyl-propionic acid ethyl ester
