A New Fluoridolyzable Anchoring Linkage for Orthogonal Solid-Phase Peptide Synthesis: Design, Preparation, and Application of the N-(3 or 4)--tert-butylphenylsilyl>phenyl Pentanedioic Acid Monoamide (Pbs) Handle

Article abstract of DOI:10.1021/jo00257a009

The silicon-containing bifunctional handle 2,4,5-trichlorophenyl N-(3 or 4)-<<4-(hydroxymethyl)phenoxy>-tert-butylphenylsilyl>phenyl pentanedioate monoamide (1) (Pbs) has been prepared and evaluated for use in a new mild approach to solid-phase peptide sy