A New Fluoridolyzable Anchoring Linkage for Orthogonal Solid-Phase Peptide Synthesis: Design, Preparation, and Application of the N-(3 or 4)--tert-butylphenylsilyl>phenyl Pentanedioic Acid Monoamide (Pbs) Handle

DOI: 10.1021/jo00257a009

Source and publish data:

Journal of Organic Chemistry p. 5240 - 5248 (1988)

Update date:2022-07-30

Topics: Design Preparation Solid-Phase Peptide Synthesis Application Orthogonal

Authors:

Mullen, Daniel G.

Barany, George

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Article abstract of DOI:10.1021/jo00257a009

The silicon-containing bifunctional handle 2,4,5-trichlorophenyl N-(3 or 4)-<<4-(hydroxymethyl)phenoxy>-tert-butylphenylsilyl>phenyl pentanedioate monoamide (1) (Pbs) has been prepared and evaluated for use in a new mild approach to solid-phase peptide sy

Full text of DOI:10.1021/jo00257a009

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