Sugar pucker

The three-dimensional conformation of the ribose or deoxyribose ring in nucleic acids.

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Synthesis NMR spectroscopy Mass spectrometry (MS) Protecting groups Deprotection HPLC (high-performance liquid chromatography) NMR (nuclear magnetic resonance) X-ray crystallography Stacking interactions Circular Dichroism (CD) Conformational Restriction Conformational Analysis Thermodynamic Stability Molecular Dynamics Simulation Hybridization Base Pairing Hydrophobicity Isosteric Replacement Structure-based design Dinucleosides Duplex stabilization Isothermal titration calorimetry (ITC) Melting temperature (Tm) Phosphoramidite chemistry Molecular Dynamics (MD) Self-complementary Duplex formation Backbone Modification Dihedral Angle

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