Tetrahedron Letters p. 2371 - 2374 (1989)
Update date:2022-07-30
Topics: Retrosynthetic analysis Purification and characterization Final steps Stereochemistry Control Purification and Isolation Formation of Key Bonds Synthesis of Fragments Assembly of Fragments Yield Optimization Spectroscopic and Analytical Confirmation
Brendel, Joachim
Weyerstahl, Peter
Silphiperfol-5-en-3-ol (1) has been synthesized in five steps starting with enone 4 in an overall yield of 30percent.Key step is a TMSCl assisted 1,4-addition of the Grignard reagent of acetal 5 to 4.
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