TOTAL SYNTHESIS OF (+/-)-SILPHIPERFOL-5-EN-3-OL

DOI: 10.1016/S0040-4039(01)80402-0

Source and publish data:

Tetrahedron Letters p. 2371 - 2374 (1989)

Update date:2022-07-30

Topics: Retrosynthetic analysis Purification and characterization Final steps Stereochemistry Control Purification and Isolation Formation of Key Bonds Synthesis of Fragments Assembly of Fragments Yield Optimization

Authors:

Brendel, Joachim

Weyerstahl, Peter

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Article abstract of DOI:10.1016/S0040-4039(01)80402-0

Silphiperfol-5-en-3-ol (1) has been synthesized in five steps starting with enone 4 in an overall yield of 30percent.Key step is a TMSCl assisted 1,4-addition of the Grignard reagent of acetal 5 to 4.

Full text of DOI:10.1016/S0040-4039(01)80402-0

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Product name:Thiocarbonic acid O-((3aS,5aR,6S,8aR)-1,2,3a,6-tetramethyl-4-oxo-decahydro-cyclopenta[c]pentalen-3-yl) ester O-p-tolyl ester

Cas No:141193-95-5

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