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| CAS No.: | 4965-33-7 |
|---|---|
| Name: | 7-Chloro-2-methylquinoline |
| Article Data: | 33 |
| Molecular Structure: | |
|
|
|
| Formula: | C10H8ClN |
| Molecular Weight: | 177.633 |
| Synonyms: | 7-Chloro-2-methylquinoline(7-Chloroquinaldine);Quinoline, 7-chloro-2-methyl-;7-chloro-2-methyl-quinoline;7-chlorquinaldine;7-Chloroquinaldine; |
| EINECS: | 440-600-3 |
| Density: | 1.225 g/cm3 |
| Melting Point: | 74-78 °C(lit.) |
| Boiling Point: | 278.177 °C at 760 mmHg |
| Flash Point: | 148.736 °C |
| Appearance: | white to light yellow crystal powder |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36 |
| PSA: | 12.89000 |
| LogP: | 3.19660 |
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4-Hydroxy-4-methyl-2-pentanone
- 59236-37-2
2-amino-4-chlorobenzaldehyde
- 4965-33-7
2-methyl-7-chloroquinoline
| Conditions | Yield |
|---|---|
| With chloro[1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I); sodium t-butanolate In toluene at 70℃; Inert atmosphere; Schlenk technique; chemoselective reaction; | 90% |
| Conditions | Yield |
|---|---|
| With phospho-tungstic acid; phosphotungstic acid; silica gel for 0.2h; Doebner-Miller reaction; microwave irradiation; | 86% |
| With hydrogenchloride; chloranil In tetrahydrofuran; methanol; iso-butanol |
- 4965-33-7
2-methyl-7-chloroquinoline
| Conditions | Yield |
|---|---|
| With tetrasodium cobalt(II) 4,4',4'',4'''-tetrasulphophthalocyanine In water; ethyl acetate at 20℃; for 18h; Irradiation; Green chemistry; | 85% |
| With rose bengal; oxygen In N,N-dimethyl acetamide at 20℃; for 24h; Irradiation; | 73% |
| With rose bengal In N,N-dimethyl acetamide at 20℃; for 28h; Irradiation; | 73% |
| With tris(bipyridine)ruthenium(II) dichloride hexahydrate; Co(dmgH)2(4-MeCO2Py)Cl In water at 28℃; for 12h; Schlenk technique; Inert atmosphere; Irradiation; | 73% |
| With 1,10-Phenanthroline; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium tert-butylate; oxygen; nickel dibromide In tert-Amyl alcohol at 95℃; for 48h; | 42% |
| Conditions | Yield |
|---|---|
| With magnetite-palladium-graphene nanocomposite In acetonitrile at 80℃; for 12h; | 72% |
- 64-17-5
ethanol
- 108-42-9
3-chloro-aniline
A
- 4965-33-7
2-methyl-7-chloroquinoline
B
- 4964-69-6
2-methyl-5-chloroquinoline
| Conditions | Yield |
|---|---|
| With iron(III) chloride hexahydrate In tetrachloromethane at 140℃; for 4h; Autoclave; Inert atmosphere; Sealed tube; | A 11% B 67% |
| Conditions | Yield |
|---|---|
| Stage #1: 3-chloro-aniline; crotonaldehyde With hydrogenchloride In water; toluene at 110℃; for 1.5h; Stage #2: With zinc(II) chloride In tetrahydrofuran; water; acetone; toluene at 60℃; for 1h; Cooling with ice; | 30% |
| With hydrogenchloride In water; toluene for 2h; Doebner-Miller Quinoline Synthesis; Reflux; | |
| With hydrogenchloride; 1-methyl-2-nitrobenzene In water at 100℃; for 9h; Reagent/catalyst; Skraup Quinoline Synthesis; Reflux; |
- 10138-89-3
1,1,3-trimethoxybutane
- 141-85-5
3-chloroaniline hydrochloride
- 4965-33-7
2-methyl-7-chloroquinoline
| Conditions | Yield |
|---|---|
| With ethanol; iron(III) chloride; zinc(II) chloride |
| Conditions | Yield |
|---|---|
| With hydrogenchloride |
- 75-07-0
acetaldehyde
- 108-42-9
3-chloro-aniline
A
- 4965-33-7
2-methyl-7-chloroquinoline
B
- 4964-69-6
2-methyl-5-chloroquinoline
| Conditions | Yield |
|---|---|
| With di-μ-chlorobis(norbornadiene)dirhodium(I); 3-Nitrochlorobenzene In ethanol at 180℃; for 4h; Yield given. Yields of byproduct given; |
- 106237-28-9
β-(m-chloroanilino)crotonaldehyde
A
- 4965-33-7
2-methyl-7-chloroquinoline
B
- 4964-69-6
2-methyl-5-chloroquinoline
| Conditions | Yield |
|---|---|
| With sulfuric acid at 25℃; Rate constant; |
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Chemistry
Molecular Structure:
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Molecular Formula: C10H8ClN
Molecular Weight: 177.6302
IUPAC Name: 7-Chloro-2-methylquinoline
Synonyms of 7-Chloroquinaldine (CAS NO.4965-33-7): Quinoline, 7-chloro-2-methyl-
CAS NO: 4965-33-7
Product Categories: Quinolines, Quinazolines and derivatives ; Halides ; Quinolines, Isoquinolines & Quinoxalines ; Quinoline&Isoquinoline ; API ; Alkylquinolines ; Haloquinolines ; Quinolines ; Quinolines, Isoquinolines & Quinoxalines
Melting point: 74-78 °C
Polar Surface Area: 12.89 Å2
Index of Refraction: 1.634
Molar Refractivity: 51.9 cm3
Molar Volume: 144.9 cm3
Surface Tension: 46.5 dyne/cm
Density: 1.225 g/cm3
Flash Point: 148.7 °C
Enthalpy of Vaporization: 49.6 kJ/mol
Boiling Point: 278.2 °C at 760 mmHg
Vapour Pressure: 0.00732 mmHg at 25°C
Uses
7-Chloroquinaldine (CAS NO.4965-33-7) is used as a Pharmaceutical intermediates.
Safety Profile
Safety Information of 7-Chloroquinaldine (CAS NO.4965-33-7):
Hazard Codes: Xi 
Risk Statements: 36/37/38
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
WGK Germany: 3