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| CAS No.: | 122-80-5 |
|---|---|
| Name: | 4'-Aminoacetanilide |
| Article Data: | 137 |
| Molecular Structure: | |
|
|
|
| Formula: | C8H10N2O |
| Molecular Weight: | 150.18 |
| Synonyms: | Acetanilide,4'-amino- (6CI,7CI,8CI);Acetanilide, p-amino- (4CI);(4-(Acetylamino)phenyl)amine;1-Amino-4-(acetylamino)benzene;4-(Acetylamino)aniline;4-Acetylaminobenzeneamine;Acetparamin;Acetyl-p-phenylenediamine;C.I. 76005;C.I.Oxidation Base 19;Fourrine 88;Fourrine A;N-(4-Aminophenyl)acetamide;N-(p-Aminophenyl)acetamide;N-Acetyl-1,4-benzenediamine;N-Acetyl-p-phenylenediamine;NSC 2135;Paracetamin;p-(Acetylamino)aniline;p-Acetamidoaniline;p-Aminoacetanilide; |
| EINECS: | 204-576-6 |
| Density: | 1.203 g/cm3 |
| Melting Point: | 164-167 °C(lit.) |
| Boiling Point: | 267.726 °C at 760 mmHg |
| Flash Point: | 115.717 °C |
| Solubility: | 0.1-1 g/100 mL at 25 °C |
| Appearance: | pink to brown fine crystalline powder |
| Hazard Symbols: |
 Xn, Xi
|
| Risk Codes: | 36-42/43-20/21/22 |
| Safety: | 22-26-36/37-39-36 |
| PSA: | 55.12000 |
| LogP: | 1.88140 |
- 144851-82-1METHYL2-AMINO-3-FLUOROBENZOATE
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
- 173606-50-3BOC-10-AMINODECANOIC ACID
- 361456-36-2METHYL (R)-(+)-ISOCYANATO-3-PHENYLPROPI&
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
| Conditions | Yield |
|---|---|
| With hydrazine hydrate; nickel In methanol for 6h; | 100% |
| With indium; acetic acid In tetrahydrofuran Heating; | 100% |
| With trimethylamine-borane; palladium hydroxide - carbon In methanol for 3.5h; Heating; | 99% |
- 64-19-7
acetic acid
- 141-78-6
ethyl acetate
- 106-50-3
1,4-phenylenediamine
- 122-80-5
N-acetyl-p-phenylenediamine
| Conditions | Yield |
|---|---|
| With 1,4-diaza-bicyclo[2.2.2]octane at 65 - 90℃; for 6h; Time; Inert atmosphere; | 98.6% |
- 38063-81-9
p-aminoacetophenone oxime
- 122-80-5
N-acetyl-p-phenylenediamine
| Conditions | Yield |
|---|---|
| With chlorosulfonic acid In toluene at 90℃; for 0.5h; Beckmann rearrangement; | 98% |
| With trifluoromethylsulfonic anhydride In dichloromethane at 20℃; for 3h; Beckmann Rearrangement; Inert atmosphere; | 94% |
| With iodine In acetonitrile for 4h; Beckmann rearrangement; Reflux; | 90% |
| Conditions | Yield |
|---|---|
| at 20℃; | 95% |
| In dichloromethane at 20℃; Inert atmosphere; | 95% |
| In tetrahydrofuran at 20℃; | 65% |
| Conditions | Yield |
|---|---|
| With bis(triphenylphosphine)nickel(II) chloride; lithium hexamethyldisilazane In 1,4-dioxane at 90℃; for 2h; Glovebox; Sealed tube; | 91% |
| Stage #1: 4-bromoacetanilide With lithium hexamethyldisilazane; DavePhos; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane at 100℃; for 17h; Stage #2: With hydrogenchloride In 1,4-dioxane at 20℃; for 0.0833333h; Further stages.; | 70% |
| Conditions | Yield |
|---|---|
| With ammonium hydroxide; potassium phosphate; 1-(5,6,7,8-tetrahydroquinolin-8-yl)-2-methylpropan-1-one; copper(I) bromide In dimethyl sulfoxide at 25℃; for 24h; Inert atmosphere; Sealed tube; | 90% |
| Conditions | Yield |
|---|---|
| With ammonium hydroxide; potassium phosphate In dimethyl sulfoxide at 80℃; UV-irradiation; | 89% |
- 106-50-3
1,4-phenylenediamine
A
- 16937-03-4
4-nitro-N-(4-chlorophenyl)benzenesulfonamide
B
- 122-80-5
N-acetyl-p-phenylenediamine
| Conditions | Yield |
|---|---|
| With potassium carbonate In water at 80℃; for 2h; Green chemistry; chemoselective reaction; | A n/a B 86% |
- 52578-66-2
N-(4-azido-phenyl)acetamide
- 122-80-5
N-acetyl-p-phenylenediamine
| Conditions | Yield |
|---|---|
| With iron(III) oxide; hydrazine hydrate In water at 120℃; for 1.5h; Inert atmosphere; | 85% |
- 127740-25-4
2-[(4-acetylaminophenylamino)methylene]malonic acid diethyl ester
- 122-80-5
N-acetyl-p-phenylenediamine
| Conditions | Yield |
|---|---|
| With ethylenediamine In ethanol at 20℃; for 1.3h; | 80% |
- 768-66-12,2,6,6-Tetramethylpiperidine
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- 33948-22-0Dibenz[b,f]azepine-5-carbonyl chloride
- 2277-92-1Benzamide,2,3,5-trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxy-
- 4773-96-09H-Xanthen-9-one, 2-b-D-glucopyranosyl-1,3,6,7-tetrahydroxy-
- 119-65-3Isoquinoline
- 112022-83-01H,3H-Pyrrolo[1,2-c][1,3,2]oxazaborole,tetrahydro-1-methyl-3,3-diphenyl-, (3aR)-
- 976-71-6Pregna-4,6-diene-21-carboxylicacid, 17-hydroxy-3-oxo-, g-lactone, (17a)-
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
- Total:23 Page 1 of 1 1
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Specification
The p-Amino acetanilide with CAS registry number of 122-80-5 is also called Acetamide,N-(4-aminophenyl)-. The IUPAC name is N-(4-aminophenyl)acetamide. Its EINECS registry number is 204-576-6. In addition, the molecular formula is C8H10N2O and the molecular weight is 150.1778. It belongs to the classes of Amineprimary; Intermediates of Dyes and Pigments; Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts. It is a kind of white or slightly reddish solid. And it is slightly soluble in water. What's more, it should be stored in a airtight, cool and dry place.
Physical properties about this chemical are: (1)ACD/LogP: 0.08; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0; (4)ACD/LogD (pH 7.4): 0; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 22; (8)ACD/KOC (pH 7.4): 26; (9)#H bond acceptors: 3; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 55.12 Å2; (13)Index of Refraction: 1.636; (14)Molar Refractivity: 44.761 cm3; (15)Molar Volume: 124.796 cm3; (16)Polarizability: 17.745 ×10-24cm3; (17)Surface Tension: 53.079 dyne/cm; (18)Density: 1.203 g/cm3; (19)Flash Point: 115.717 °C; (20)Enthalpy of Vaporization: 50.577 kJ/mol; (21)Boiling Point: 267.726 °C at 760 mmHg; (22)Vapour Pressure: 0.008 mmHg at 25°C.
Preparation of p-Amino acetanilide: it can be prepared by p-nitroacetylaniline. p-Nitroacetylaniline can be prepared by acetylaniline. At first, you can put the sulfuric acid into the kettle, then add the acetylaniline in 2-2.5 hours with stirring at the temperature of 20-25 °C and make the whole to dissolve. Then cool the mixture to 4-7 ℃, add mix acid in 20 hours by dropping. After the separation process, you can get p-nitroacetylaniline. At last, you can use iron powder to resolve p-nitroacetylaniline to get p-Amino acetylaniline.
Uses of p-Amino acetanilide: it can be used in organic synthesis and pharmaceutical industry. it can be used as Azo Dye Intermediates. It can react with hexane-1-sulfonyl chloride to get N-(4-acetamidophenyl)sulfamoylhexane. This reaction will need reagent pyridine. The yield is about 83%.
When you are using this chemical, please be cautious about it as the following:
It is irritating to eyes and harmful by inhalation, in contact with skin and if swallowed. And it may cause sensitization by inhalation and skin contact. During using it, you should not breathe dust and should wear suitable protective clothing, gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1)SMILES: Nc1ccc(NC(C)=O)cc1
(2)InChI: InChI=1/C8H10N2O/c1-6(11)10-8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)
(3)InChIKey: CHMBIJAOCISYEW-UHFFFAOYAK
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | oral | 633mg/kg (633mg/kg) | Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology. Vol. (10), Pg. 36, 1996. | |
| rat | LD50 | oral | 2500mg/kg (2500mg/kg) | Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology. Vol. (10), Pg. 36, 1996. |