Products Categories
| CAS No.: | 18621-17-5 |
|---|---|
| Name: | 1-(Diphenylmethyl)-3-hydroxyazetidine |
| Article Data: | 42 |
| Cas Database | |
| Molecular Structure: | |
|
|
|
| Formula: | C16H17NO |
| Molecular Weight: | 239.317 |
| Synonyms: | 1-Benzhydryl-3-azetanol;1-Benzhydryl-3-hydroxyazetidine;1-Benzhydrylazetidin-3-ol;3-Hydroxy-1-(diphenylmethyl)azetidine;N-(Diphenylmethyl)-3-hydroxyazetidine;N-(Diphenylmethyl)azetidin-3-ol;3-Azetidinol,1-(diphenylmethyl)-; |
| EINECS: | 606-074-6 |
| Density: | 1.189 g/cm3 |
| Melting Point: | 106 °C |
| Boiling Point: | 353.8 °C at 760 mmHg |
| Flash Point: | 101.7 °C |
| Appearance: | white solid |
| Hazard Symbols: |
 Xi, C
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-37/39 |
| PSA: | 23.47000 |
| LogP: | 2.39040 |
- 18621-18-63-Hydroxyazetidine hydrochloride
- 1862-17-54-Morpholinehexanoicacid, e-oxo-
- 18622-23-6[1,1'-Biphenyl]-4-carboxylicacid, hydrazide
- 18622-28-1Cyanamide, N-cyano-, zinc salt (2:1)
- 18623-11-5Silane, octadecyl-
- 18623-13-71,9-Dioxa-2,8,10,16-tetrasilacyclohexadecane-5,13-dione,2,2,8,8,10,10,16,16-octamethyl-
- 18625-12-2Butanoic acid,4-(2,4-dichlorophenoxy)-, methyl ester
- 18625-22-4Glycine,D-leucylglycyl-
- 186259-63-29H-Fluorene,2,7-dibromo-9,9-diphenyl-
- 186296-21-9Acetamide,N-[(1R)-1-(4-chlorophenyl)ethyl]-
| Conditions | Yield |
|---|---|
| With sodium carbonate In isopropyl alcohol for 12h; Solvent; Temperature; Reagent/catalyst; Reflux; | 88.2% |
| In methanol for 72h; Inert atmosphere; | 83% |
| With hydrogenchloride In N,N-dimethyl-formamide | 74% |
- 40320-60-3
N-benzhydryl 3-azetidinone
- 18621-17-5
1-(diphenylmethyl)-3-hydroxyazetidine
| Conditions | Yield |
|---|---|
| With methanol; sodium tetrahydroborate at 0 - 20℃; | 86.2% |
| With sodium tetrahydroborate |
- 18621-17-5
1-(diphenylmethyl)-3-hydroxyazetidine
| Conditions | Yield |
|---|---|
| With Nonafluorobutanesulfonyl fluoride; TPGS-750-M In propan-1-ol; water at 50℃; for 24h; Reagent/catalyst; Solvent; Temperature; Green chemistry; | 80% |
- 63477-43-0
3-chloro-1-diphenylmethylamino-2-hydroxypropane
- 18621-17-5
1-(diphenylmethyl)-3-hydroxyazetidine
| Conditions | Yield |
|---|---|
| With N-ethyl-N,N-diisopropylamine In ethanol at 0 - 90℃; | 75% |
| With triethylamine In acetonitrile for 49h; Reflux; | 65% |
| In ethanol for 3h; Heating / reflux; | |
| With triethylamine In methanol; acetonitrile Reflux; |
- 552-82-9
benzhydrylidene(methyl)amine
- 106-89-8
epichlorohydrin
- 18621-17-5
1-(diphenylmethyl)-3-hydroxyazetidine
| Conditions | Yield |
|---|---|
| In DMF (N,N-dimethyl-formamide) at 95℃; for 72h; | 74% |
- 18621-17-5
1-(diphenylmethyl)-3-hydroxyazetidine
- 124-63-0
methanesulfonyl chloride
- 33301-41-6
1-benzhydryl-3-azetidinyl methanesulfonate
| Conditions | Yield |
|---|---|
| With triethylamine In dichloromethane at 0℃; for 2h; | 100% |
| With triethylamine In dichloromethane at 0℃; | 100% |
| With triethylamine In dichloromethane at 20℃; for 1h; Product distribution / selectivity; | 100% |
- 18621-17-5
1-(diphenylmethyl)-3-hydroxyazetidine
- 124-63-0
methanesulfonyl chloride
- 106859-45-4
1-(Diphenylmethyl)-3-azetidinol methanesulfonate (ester) hydrochloride
| Conditions | Yield |
|---|---|
| Stage #1: 1-(diphenylmethyl)-3-hydroxyazetidine; methanesulfonyl chloride With triethylamine In benzene at 0 - 20℃; Stage #2: With hydrogenchloride In diethyl ether at 0℃; | 100% |
- 18621-17-5
1-(diphenylmethyl)-3-hydroxyazetidine
- 90604-02-7
1-(diphenylmethyl)-3-azetidinol hydrochloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride In ethyl acetate at 20℃; for 0.166667h; | 100% |
- 18621-17-5
1-(diphenylmethyl)-3-hydroxyazetidine
- 1538-75-6
2,2-dimethylpropanoic anhydride
- 141699-55-0
tert-butyl 3-hydroxyazetidine-1-carboxylate
| Conditions | Yield |
|---|---|
| With hydrogen; 20% Pd(OH)2 on carbon In ethyl acetate under 760.051 Torr; for 24h; | 100% |
- 18621-17-5
1-(diphenylmethyl)-3-hydroxyazetidine
- 18162-48-6
tert-butyldimethylsilyl chloride
- 391910-20-6
3-((tert-butyldimethylsilyl)oxy)-1-(diphenylmethyl)azetidine
| Conditions | Yield |
|---|---|
| With 1H-imidazole In dichloromethane at 20℃; for 0.5h; | 100% |
| With 1H-imidazole In dichloromethane at 20℃; for 3h; | 99.8% |
| With 1H-imidazole In N,N-dimethyl-formamide; toluene at 0 - 20℃; for 22h; | 53% |
- 312-84-5D-Serine
- 89-25-83-Methyl-1-phenyl-2-pyrazolin-5-one
- 55268-74-1Praziquantel
- 135046-48-9(+/-)-Clopidogrel bisulfate
- 36322-90-4Piroxicam
- 665-66-71-Adamantanamine hydrochloride
- 191732-72-6Lenalidomide
- 2446-23-3Androsta-1,4-dien-3-one,4-chloro-17-hydroxy-17-methyl-, (17b)-
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
What can I do for you?
Get Best Price
Chemistry
.jpg)
IUPAC Name: 1-Benzhydrylazetidin-3-ol
Canonical SMILES: C1C(CN1C(C2=CC=CC=C2)C3=CC=CC=C3)O
InChI: InChI=1S/C16H17NO/c18-15-11-17(12-15)16(13-7-3-1-4-8-13)14-9-5-2-6-10-
14/h1-10,15-16,18H,11-12H2
InChIKey: MMAJXKGUZYDTHV-UHFFFAOYSA-N
Molecular Weight: 239.31228 [g/mol]
Molecular Formula: C16H17NO
XLogP3-AA: 2.6
H-Bond Donor: 1
H-Bond Acceptor: 2
Product Categories: Alcohols and Derivatives; Azetidine; N-Benzhydrylazetidin; Azetidines; Amines; Heterocycles; Ring Systems
Appearance: White solid
Index of Refraction: 1.64
Molar Refractivity: 72.55 cm3
Molar Volume: 201.1 cm3
Surface Tension: 54.8 dyne/cm
Density: 1.189 g/cm3
Flash Point: 101.7 °C
Enthalpy of Vaporization: 63.18 kJ/mol
Boiling Point: 353.8 °C at 760 mmHg
Vapour Pressure: 1.29E-05 mmHg at 25 °C
Melting Point of 1-(Diphenylmethyl)-3-hydroxyazetidine (CAS NO.18621-17-5): 106 °C
Uses
1-(Diphenylmethyl)-3-hydroxyazetidine (CAS NO.18621-17-5) is used to identify inhibitors of CYP 3A4.
Safety Profile
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39:Wear suitable gloves and eye/face protection.
Hazard Codes: 
Xi,
C
Hazard Note: Irritant
HazardClass of 1-(Diphenylmethyl)-3-hydroxyazetidine (CAS NO.18621-17-5): IRRITANT
Specification
1-(Diphenylmethyl)-3-hydroxyazetidine (CAS NO.18621-17-5), its Synonyms are 1-(Diphenylmethyl)-3-azetidinol ; 1-Benzhydryl-3-azetanol ; 1-Benzhydryl-3-hydroxyazetidine ; 1-Benzhydrylazetidin-3-ol ; 3-Hydroxy-1-(diphenylmethyl)azetidine ; N-(Diphenylmethyl)-3-hydroxyazetidine ; 3-Azetidinol,1-(diphenylmethyl)- .
-
Premium Related Products
