Products Categories
| CAS No.: | 455-14-1 |
|---|---|
| Name: | 4-Aminobenzotrifluoride |
| Article Data: | 154 |
| Molecular Structure: | |
|
|
|
| Formula: | C7H6F3N |
| Molecular Weight: | 161.127 |
| Synonyms: | p-Toluidine,a,a,a-trifluoro-(6CI,7CI,8CI);(4-(Trifluoromethyl)phenyl)amine;1-Amino-4-(trifluoromethyl)benzene;4-(Trifluoromethyl)aniline;4-(Trifluoromethyl)benzenamine;4-Amino-a,a,a-benzotrifluoride;NSC 10337;p-(Trifluoromethyl)aniline;p-Amino-a,a,a-trifluorotoluene;p-Aminobenzotrifluoride;p-Trifluoromethylphenylamine;a,a,a-Trifluoro-p-toluidine;4-Aminotrifluorotoluene; |
| EINECS: | 207-236-5 |
| Density: | 1.286 g/cm3 |
| Melting Point: | 3-8 °C |
| Boiling Point: | 190 °C at 760 mmHg |
| Flash Point: | 86.7 °C |
| Solubility: | <0.1 g/100 mL in water |
| Appearance: | clear colorless to yellow liquid |
| Hazard Symbols: |
 T,  N,  Xi,  Xn
|
| Risk Codes: | 25-36-50/53-36/37/38-33-20/21/22 |
| Safety: | 26-45-60-61-36/37/39-36 |
| Transport Information: | UN 2810 6.1/PG 3 |
| PSA: | 26.02000 |
| LogP: | 2.86880 |
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 852475-26-4MC1568
- 958254-66-51H-Imidazo[4,5-b]pyridine-2-carboxaldehyde, 1-methyl-, hydrochloride
| Conditions | Yield |
|---|---|
| With Zr12(μ3-O)5[(μ3-O)CoCl]8[(μ2-O)2(μ3-O)CoCl]3Li3(triphenyldicarboxylate)9; hydrogen; sodium triethylborohydride In toluene at 110℃; under 30003 Torr; for 42h; Catalytic behavior; Inert atmosphere; Schlenk technique; | 100% |
| With hydrazine hydrate In ethanol at 40℃; for 0.5h; | 99% |
| With LaCu0.67Si1.33; hydrogen In isopropyl alcohol at 120℃; under 22502.3 Torr; for 54h; Autoclave; | 99% |
| Conditions | Yield |
|---|---|
| nickel In methanol for 1h; Heating / reflux; | 100% |
| With hydrogen; nickel In methanol at 20℃; under 3750.38 Torr; for 2h; | 75% |
| Conditions | Yield |
|---|---|
| With C24H32N2*ClCu; ammonia; potassium carbonate In 1-methyl-pyrrolidin-2-one; methanol at 90℃; under 5171.62 Torr; for 24h; Inert atmosphere; | 95% |
| With ammonium hydroxide; copper(l) iodide; potassium carbonate; 4R-4-hydroxyproline In dimethyl sulfoxide at 50℃; for 24h; | 91% |
| Stage #1: p-trifluoromethylphenyl bromide With bis(bis(trimethylsilyl)amido)zinc(II); tri-tert-butyl phosphine; lithium chloride; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran at 50℃; for 4h; Stage #2: With hydrogenchloride In tetrahydrofuran; diethyl ether | 90% |
| Conditions | Yield |
|---|---|
| With ammonium hydroxide; caesium carbonate In water for 1h; Reflux; Green chemistry; | 92% |
| With ammonium hydroxide; caesium carbonate In water for 1h; Catalytic behavior; Reflux; | 92% |
| With ammonium hydroxide; caesium carbonate In acetonitrile for 1h; Reflux; Green chemistry; | 91% |
| Conditions | Yield |
|---|---|
| With water for 5h; Inert atmosphere; UV-irradiation; Sealed tube; chemoselective reaction; | 92% |
| With C36H44CuN8(1+)*BF4(1-) In water; toluene at 100℃; for 20h; Sealed tube; chemoselective reaction; | 64% |
| With sodium tetrahydroborate In methanol; water at 20℃; for 0.333333h; Green chemistry; | > 99 %Chromat. |
| With sodium tetrahydroborate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 In methanol; water at 20℃; for 0.166667h; | |
| With sodium tetrahydroborate In water at 20℃; for 0.416667h; Green chemistry; | > 99 %Chromat. |
| Conditions | Yield |
|---|---|
| Stage #1: 4-chlorobenzotrifluoride With bis(bis(trimethylsilyl)amido)zinc(II); tri-tert-butyl phosphine; lithium chloride; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran at 90℃; for 18h; Stage #2: With hydrogenchloride In tetrahydrofuran; diethyl ether | 88% |
| With ammonium hydroxide; potassium phosphate In dimethyl sulfoxide at 80℃; UV-irradiation; | 86% |
| With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; ammonia; sodium t-butanolate In 1,4-dioxane at 110℃; Buchwald-Hartwig Coupling; Inert atmosphere; Glovebox; | 62% |
- 75092-01-2
4-trifluoromethylcyclohexanone oxime
- 455-14-1
4-trifluoromethylphenylamine
| Conditions | Yield |
|---|---|
| With Pd(OH)x/LDH In N,N-dimethyl acetamide at 150℃; for 1h; Schlenk technique; Inert atmosphere; | 85% |
| Conditions | Yield |
|---|---|
| With [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); formic acid; bis(trifluoromethanesulfonyl)amide; triethylamine; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In dibutyl ether at 130℃; for 24h; | A 79% B n/a |
- 128796-39-4
4-trifluoromethylphenylboronic acid
- 455-14-1
4-trifluoromethylphenylamine
| Conditions | Yield |
|---|---|
| With O-(2,4-dinitrophenyl)hydroxylamine In toluene at 80℃; for 96h; Inert atmosphere; | 78% |
| With copper(I) oxide; ammonium hydroxide; oxygen; sodium hydroxide In water at 25℃; for 24h; | 70% |
| With sodium hydroxide; hydroxylamine-O-sulfonic acid In acetonitrile at 20℃; for 5h; Reflux; | 57% |
- 120120-28-7
4-(triethylsiloxy)-4-(trifluoromethyl)-2,5-cyclohexadien-1-one
- 455-14-1
4-trifluoromethylphenylamine
| Conditions | Yield |
|---|---|
| With glycine ethyl ester hydrochloride; sodium hydrogencarbonate In ethanol for 6h; Heating; | 73% |
- 37640-57-6Melamine cyanurate
- 846-48-0Boldenone
- 154229-18-2Androsta-5,16-dien-3-ol,17-(3-pyridinyl)-, acetate (ester), (3b)-
- 16961-83-4Hexafluorosilicic acid
- 72509-76-3Felodipine
- 220000-87-32-Pyridinecarboxamide,4-chloro-N-methyl-
- 58-63-9Inosine
- 149-73-5Trimethoxymethane
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
What can I do for you?
Get Best Price
Chemistry
Synonyms: TIMTEC-BB SBB003956;P-(TRIFLUOROMETHYL)ANILINE;P-AMINOBENZOTRIFLUORIDE;1-AMINO-4-(TRIFLUOROMETHYL)BENZENE;4-(TRIFLUOROMETHYL)ANILINE;4-AMINOBENZOTRIFLUORIDE;4-AMINO-A,A,A-TRIFLUOROTOLUENE;A,A,A-TRIFLUORO-P-TOLUIDINE
Molecular formula: C7H6F3N
Molar mass: 161.12
EINECS: 207-236-5
Melting point:3-8 °C
Boiling point :83 °C12 mm Hg(lit.)
density:1.283 g/mL at 25 °C(lit.)
refractive index:n20/D 1.483(lit.)
Fp :188 °F
Water Solubility:<0.1 g/100 mL
Uses
Toxicity Data With Reference
| 1. | mmo-sat 10 mg/L | ENMUDM Environmental Mutagenesis. 5 (1983),803. | ||
| 2. | mmo-esc 10 mg/L | ENMUDM Environmental Mutagenesis. 5 (1983),803. | ||
| 3. | ipr-mus LD50:101 mg/kg | JMCMAR Journal of Medicinal Chemistry. 17 (1974),900. |
Consensus Reports
Safety Profile
Poison by intraperitoneal route. Mutation data reported. When heated to decomposition it emits very toxic fumes of F− and NOx. See also FLUORIDES.
Hazard Codes: 
T, 
N, 
Xi, Xn
Hazard Note: Toxic/Irritant
The Risk Statements information of p-TRIFLUOROMETHYLANILINE:
25: Toxic if swallowed
33: Danger of cumulative effects
36: Irritating to the eyes
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
50/53: Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
The Safety Statements information of p-TRIFLUOROMETHYLANILINE:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
60: This material and/or its container must be disposed of as hazardous waste
61: Avoid release to the environment. Refer to special instructions safety data sheet
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
RIDADR: UN 2810 6.1/PG 3
WGK Germany: 3
RTECS: XU9260000