CAS No.516-12-1,N-Iodosuccinimide Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	516-12-1
Name:	N-Iodosuccinimide
Article Data:	20

Formula:	C₄H₄INO₂
Molecular Weight:	224.986
Synonyms:	5-21-09-00544 (Beilstein Handbook Reference);Succinimide, N-iodo-;N-Iodosuccinimide 99%;2,5-Pyrrolidinedione, 1-iodo- (9CI);1-Iodopyrrolidine-2,5-dione;Succiniodimide;
EINECS:	208-221-6
Density:	2.31 g/cm³
Melting Point:	173 -175
Boiling Point:	249.6 °C at 760 mmHg
Flash Point:	104.8 °C
Solubility:	decomposes in water
Appearance:	white-yellow to brown crystalline powder
Hazard Symbols:	Xn,Xi
Risk Codes:	22-36/37/38
Safety:	26-36-37/39
PSA:	37.38000
LogP:	0.42330

Synthetic route

: 123-56-8
Succinimide

: 516-12-1
N-iodo-succinimide

Conditions

Conditions	Yield
With [bis(acetoxy)iodo]benzene; iodine In benzene at 20℃; for 15h; Concentration; Solvent; Time; Darkness;	99%
With Iodine monochloride; bis(tri-n-butyltin)oxide 1.) benzene, reflux, 4 h, 2.) CH3CN; Yield given. Multistep reaction;

: 128-09-6
N-chloro-succinimide

: 516-12-1
N-iodo-succinimide

Conditions

Conditions	Yield
With sodium iodide In acetone for 0.25h;	89%
With sodium iodide In acetone for 2h;	44%
With sodium iodide In acetone for 0.25h;
With sodium iodide In N,N-dimethyl-formamide at 20℃; for 1h;
With sodium iodide In acetone for 0.25h;

: 128-08-5
N-Bromosuccinimide

: 516-12-1
N-iodo-succinimide

Conditions

Conditions	Yield
With iodine In tetrachloromethane at 40 - 50℃; for 1h;	80%
With iodine In (2)H8-toluene at 20℃;
With iodine In tetrachloromethane at 40 - 55℃;

: 123-56-8
Succinimide

: 7553-56-2
iodine

: 67-64-1
acetone

: 516-12-1
N-iodo-succinimide

Conditions

Conditions	Yield
Ausgangstoff ist Succinimid-silber;

...Expand

mercury comp bond of succinimide: mercury comp bond of succinimide

: 516-12-1
N-iodo-succinimide

Conditions

Conditions	Yield
With acetic acid ester; iodine

silver compound of succinimide: silver compound of succinimide

: 516-12-1
N-iodo-succinimide

Conditions

Conditions	Yield
With iodine; acetone
With diethyl ether; iodine

silver-compound of succinimide: silver-compound of succinimide

: 516-12-1
N-iodo-succinimide

Conditions

Conditions	Yield
With iodine; ethyl acetate
With iodine; acetone
With 1,4-dioxane; iodine

: 516-12-1
N-iodo-succinimide

: 167033-03-6
((C2H5)2C2B4H4)Nb(Cl)2(C5H5)

: 266323-96-0
C5H5Cl2Nb((C2H5)2C2B4H3I)

Conditions

Conditions	Yield
In tetrahydrofuran Nb-complex was dissolved in THF, ligand was added, shaken for 5 min under inert atm.; after 10 min solvent was removed by rotary evaporator, residue was redissolved in CH2Cl2, flash-chromd. on silica, solvent was removed; elem. anal.;	100%

: 516-12-1
N-iodo-succinimide

: (η5-C5H5)Co(Et2C2B3H5)

: (C5H5)Co((C2H5)2C2B3H3I2)

Conditions

Conditions	Yield
In not given inert atmosphere;	100%

: 516-12-1
N-iodo-succinimide

: (C5(CH3)5)Co((CH3CH2)2C2B3H4Br)

: (η(5)-C5Me5)Co(2,3-Et2C2B3H3-4-Br-6-I)

Conditions

Conditions	Yield
In tetrahydrofuran inert atmosphere; stirring (15 min); evapn., chromy. (SiO2, hexane);	100%

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Chemistry

Molecular Structure of N-Iodosuccinimide (CAS NO.516-12-1):

IUPAC Name: 1-iodopyrrolidine-2,5-dione
Empirical Formula: C₄H₄INO₂
Molecular Weight: 224.9845
Index of Refraction: 1.653
Surface Tension: 62.4 dyne/cm
Density: 2.31 g/cm³
Flash Point: 104.8 °C
Enthalpy of Vaporization: 48.69 kJ/mol
Boiling Point: 249.6 °C at 760 mmHg
Vapour Pressure: 0.0227 mmHg at 25°C
storage temp.:2-8°C
Water Solubility: decomposes
Synonyms of N-Iodosuccinimide (CAS NO.516-12-1): 1-Iodo-2,5-pyrrolidinedione ; nis;n-iodosuccinimide ; 1-iodo-5-pyrrolidinedione ; n-iodo-succinimid ; succinimide,n-iodo- ; succiniodimide ; 1-iodopyrrolidine-2,5-dione

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intravenous	180mg/kg (180mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02815,

Safety Profile

Hazard Codes Harmful Xn, Irritant Xi
Risk Statements 22-36/37/38
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37/39:Wear suitable gloves and eye/face protection.

Specification

N-Iodosuccinimide (CAS NO.516-12-1) is a white-yellow to brown crystalline powder,be sensitive to water and ligh.In organic synthesis for ketones, aldehydes of iodide, primarily as a pharmaceutical intermediates in the biological drug, its production method is without light conditions, in reaction of succinimide and silver oxide, Preparation N-succinic imide silver, in dry dioxane in the reaction ti get N-iodo succinimide.