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Basic Information
CAS No.: 563-96-2
Name: Glyoxylic acid monohydrate
Molecular Structure:
Molecular Structure of 563-96-2 (Glyoxylic acid monohydrate)
Formula: C2H4O4
Molecular Weight: 92.0514
Synonyms: 2,2-dihydroxyacetate;Glyoxylic acid 1-hydrate;
EINECS: 206-058-5
Density: 1.33 g/mL at 20 °C
Melting Point: 49-52 °C(lit.)
Boiling Point: 300.934 °C at 760 mmHg
Flash Point: 150.027 °C
Solubility: water: 0.1 g/mL, clear
Appearance: white to light yellow crystalline powder
Hazard Symbols: CorrosiveC,IrritantXi
Risk Codes: 34-43-41
Safety: 26-36/37/39-45-37/39-24-27
Transport Information: UN 3265 8/PG 2
PSA: 63.60000
LogP: -0.79440
Synthetic route
298-12-4

Glyoxilic acid

563-96-2

2,2-dihydroxyacetic acid

Conditions
ConditionsYield
at 25℃; Kinetics; in wss. Loesungen vom pH 8.27 bis pH 9.97;
With water In water-d2 at 20℃;
298-12-4

Glyoxilic acid

98480-38-7

(4S,5S)-4,5-Dihydroxy-[1,3]dioxolane-2-carboxylic acid

B

(2,2-Dihydroxy-acetoxy)-hydroxy-acetic acid

C

98453-07-7, 98453-08-8

(Carboxy-hydroxy-methoxy)-hydroxy-acetic acid

D

563-96-2

2,2-dihydroxyacetic acid

Conditions
ConditionsYield
With water at 45℃; Product distribution; effect of the concentration;
7664-93-9

sulfuric acid

298-12-4

Glyoxilic acid

563-96-2

2,2-dihydroxyacetic acid

Conditions
ConditionsYield
at 25℃; Kinetics;
60-35-5

acetamide

563-96-2

2,2-dihydroxyacetic acid

63327-49-1

N-acetyl-α-hydroxyglycine

Conditions
ConditionsYield
In acetone for 20h; Heating;100%
In acetone
552-41-0

1-(2-hydroxy-4-methoxyphenyl)ethanone

563-96-2

2,2-dihydroxyacetic acid

117379-73-4

2-Hydroxy-4-(2-hydroxy-4-methoxy-phenyl)-4-oxo-butyric acid

Conditions
ConditionsYield
at 95℃; under 50 Torr; for 3h;100%
72824-04-5

2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

563-96-2

2,2-dihydroxyacetic acid

1069-48-3, 7685-44-1

rac-allylglycine

Conditions
ConditionsYield
Stage #1: 2,2-dihydroxyacetic acid With ammonium hydroxide In ethanol at 20℃; for 0.5h;
Stage #2: 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane In ethanol at 20℃; for 3h;
100%
621-84-1

O-benzyl carbamate

563-96-2

2,2-dihydroxyacetic acid

79002-45-2

N-benzyloxycarbonyl-glycine

Conditions
ConditionsYield
In toluene at 40℃;100%
In toluene at 40℃; for 3.5h;100%
In toluene at 40℃; for 3.5h; Large scale reaction;96%
In diethyl ether at 20℃; for 10h;
83-33-0

inden-1-one

563-96-2

2,2-dihydroxyacetic acid

114915-75-2

1-oxoindan-Δ2,α-acetic acid

Conditions
ConditionsYield
With sulfuric acid Inert atmosphere;100%
563-96-2

2,2-dihydroxyacetic acid

A

144-62-7

oxalic acid

B

298-12-4

Glyoxilic acid

Conditions
ConditionsYield
With oxygen; ethylenediamine; Flavin mononucleotide In water at 15℃; under 4350.3 Torr; for 77h; glycolate oxidase, Aspergillus niger catalase, pH 8-9;A 0.2%
B 99.8%
626-62-0

1-iodocyclohexane

2687-43-6

O-benzylhydoxylamine hydrochloride

563-96-2

2,2-dihydroxyacetic acid

2-(benzyloxyamino)-2-cyclohexylethanoic acid

Conditions
ConditionsYield
Stage #1: O-benzylhydoxylamine hydrochloride; 2,2-dihydroxyacetic acid In water at 20℃; for 3h; Condensation;
Stage #2: Cyclohexyl iodide With triethyl borane In hexane; water at 20℃; for 1h; Addition; Further stages.;
99%
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Chemistry

Molecular Formula: C2H4O4  
Molecular Weight: 92.05
IUPAC Name: oxaldehydic acid hydrate
Synonyms: Dihydroxyacetic acid ; Formylformic acid ; Oxoethanoic acid ; Formylformic acid monohydrate ; Oxoethanoic acid monohydrate
Melting Point: 49-52 °C (lit.)
Boiling Point: 100°C (lit.)
Density of Glyoxylic acid monohydrate (563-96-2) : 1.33 g/mL at 20 °C
Refractive index: n20/D 1.414
Flash Point: >230 °F
Storage temp.: 2-8 °C
Sensitive: Hygroscopic
Enthalpy of Vaporization: 62.76 kJ/mol
Vapour Pressure: 0.000107 mmHg at 25 °C
Solubility of Glyoxylic acid monohydrate (563-96-2): H2O: 0.1 g/mL, clear
Chemical Properties: Glyoxylic acid monohydrate (563-96-2) is a white to light yellow crystalline powder or chunks

Uses

In industrial field, Glyoxylic acid monohydrate (563-96-2) is used as a basic chemical for the synthesis of other chemical products of acids, esters, cyclic compounds.

Toxicity Data With Reference

 Carcinogenicity: Glyoxylic acid - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
Water - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.

Other: The toxicological properties have not been fully investigated. See actual entry in RTECS for complete information.
 

Safety Profile

Hazard Codes: CorrosiveC,IrritantXi
Risk Statements: 34-43-41
34: Causes burns
43: May cause sensitization by skin contact
41: Risk of serious damage to eyes 
Safety Statements: 26-36/37/39-45-37/39-24-27
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
37/39: Wear suitable gloves and eye/face protection
24: Avoid contact with skin
27: Take off immediately all contaminated clothing
RIDADR: UN 3265 8/PG 2
WGK Germany: 1
RTECS: MD4550000
F: 3: Hygroscopic
HazardClass: 8
PackingGroup: III

Standards and Recommendations

Assay: 98.0% min

Specification

 Glyoxylic Acid Monohydrate, its cas register number is 563-96-2. It also can be called Dihydroxyacetic acid; Formylformic acid; Oxoethanoic acid, and its IUPAC name is (oxaldehydic acid hydrate.  L-serine (CAS NO.56-45-1) is hygroscopic, it can absorbs moisture or water from the air. And it is incompatible with strong oxidizing agents,strong bases. L-serine's  hazardous decomposition products are carbon monoxide, formaldehyde and carbon dioxide.Glyoxylic acid monohydrate (563-96-2) is a white to light yellow crystalline powder or chunks. In industrial field, Glyoxylic acid monohydrate (563-96-2) is used as a basic chemical for the synthesis of other chemical products of acids, esters, cyclic compounds. It should keep container tightly closed and  keep container in a cool, well-ventilated area.