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| CAS No.: | 673-22-3 |
|---|---|
| Name: | 2-Hydroxy-4-methoxybenzaldehyde |
| Article Data: | 100 |
| Molecular Structure: | |
|
|
|
| Formula: | C8H8O3 |
| Molecular Weight: | 152.15 |
| Synonyms: | p-Anisaldehyde,2-hydroxy- (6CI,7CI,8CI);2-Formyl-5-methoxyphenol;2-Hydroxy-p-anisaldehyde;4-Methoxy-6-hydroxybenzaldehyde;4-Methoxysalicylaldehyde;NSC 155334;o-Hydroxy-p-methoxybenzaldehyde; |
| EINECS: | 211-604-0 |
| Density: | 1.231 g/cm3 |
| Melting Point: | 41-43 °C(lit.) |
| Boiling Point: | 271.5 °C at 760 mmHg |
| Flash Point: | 112.1 °C |
| Solubility: | Solubility in methanol is almost transparent. Insoluble in water. |
| Appearance: | creamy white to beige or light brown cryst. powder |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36-24/25 |
| PSA: | 46.53000 |
| LogP: | 1.21330 |
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| Conditions | Yield |
|---|---|
| With triethylamine; magnesium chloride In tetrahydrofuran Inert atmosphere; Reflux; | 98% |
| With triethylamine; magnesium chloride In tetrahydrofuran Inert atmosphere; Reflux; regioselective reaction; | 92% |
| Stage #1: O-methylresorcine With triethylamine; magnesium chloride In acetonitrile at 20℃; for 0.25h; Stage #2: formaldehyd In acetonitrile Reflux; | 89% |
- 59648-29-2
2-(hydroxymethyl)-5-methoxyphenol
- 673-22-3
2-Hydroxy-4-methoxybenzaldehyde
| Conditions | Yield |
|---|---|
| With oxygen In ethanol at 20℃; under 760.051 Torr; for 0.316667h; Catalytic behavior; Green chemistry; | 98% |
| With dihydrogen peroxide at 20℃; for 3.5h; Catalytic behavior; Green chemistry; | 98% |
| With air; (acryl-TEMPO)-co-(allylamine-treated chlorophyll b-Co(III) complex) immobilized on SiO2-covered Fe3O4 magnetic nanoparticles In water at 25℃; for 0.333333h; | 94% |
| With oxygen In aq. buffer at 45℃; for 13h; pH=4.5; Reagent/catalyst; Green chemistry; | 93 %Chromat. |
- 954374-77-7
ethyl (E)-3-(2-formyl-5-methoxyphenoxy)acrylate
- 2298-07-9
4-Bromo-1-naphthylamine
A
- 673-22-3
2-Hydroxy-4-methoxybenzaldehyde
| Conditions | Yield |
|---|---|
| With trifluoroacetic acid In dichloromethane at 20℃; | A n/a B 95% |
- 954374-77-7
ethyl (E)-3-(2-formyl-5-methoxyphenoxy)acrylate
- 106-49-0
p-toluidine
A
- 673-22-3
2-Hydroxy-4-methoxybenzaldehyde
B
- 954374-93-7
C30H33NO8
| Conditions | Yield |
|---|---|
| With trifluoroacetic acid In dichloromethane at 20℃; | A n/a B 95% |
| Conditions | Yield |
|---|---|
| With aluminum (III) chloride In dichloromethane at -5 - 25℃; | 94% |
| With boron trichloride Ambient temperature; | 93% |
| With boron trichloride In dichloromethane at 0 - 20℃; for 16h; Dealkylation; | 93% |
- 50-00-0
formaldehyd
- 150-19-6
O-methylresorcine
A
- 673-22-3
2-Hydroxy-4-methoxybenzaldehyde
B
- 700-44-7
6-methoxysalicylaldehyde
| Conditions | Yield |
|---|---|
| With triethylamine; magnesium chloride In acetonitrile for 2h; Heating; | A 91% B 5% |
| With triethylamine; magnesium chloride |
| Conditions | Yield |
|---|---|
| Stage #1: 2-iodo-5-methoxyphenol With iodine; triethylamine; triphenylphosphine In dichloromethane; toluene at 20℃; for 0.0833333h; Sealed tube; Green chemistry; Stage #2: formic acid In dichloromethane; toluene at 70℃; for 1.5h; Sealed tube; Green chemistry; | 91% |
- 20503-09-7
2-(2-hydroxy-4-methoxyphenyl)acetic acid
- 673-22-3
2-Hydroxy-4-methoxybenzaldehyde
| Conditions | Yield |
|---|---|
| With benzyltriphenylphosphonium peroxodisulfate In acetonitrile for 0.5h; Oxidation; decarboxylation; Heating; | 90% |
- 954374-77-7
ethyl (E)-3-(2-formyl-5-methoxyphenoxy)acrylate
- 108-42-9
3-chloro-aniline
A
- 673-22-3
2-Hydroxy-4-methoxybenzaldehyde
| Conditions | Yield |
|---|---|
| With trifluoroacetic acid In dichloromethane at 20℃; | A n/a B 90% |
- 954374-77-7
ethyl (E)-3-(2-formyl-5-methoxyphenoxy)acrylate
- 75-31-0
isopropylamine
A
- 673-22-3
2-Hydroxy-4-methoxybenzaldehyde
| Conditions | Yield |
|---|---|
| With trifluoroacetic acid In dichloromethane at 20℃; | A n/a B 89% |
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Chemistry
Product Name: Benzaldehyde,2-hydroxy-4-methoxy- (CAS NO.673-22-3)
IUPAC Name: 2-hydroxy-4-methoxybenzaldehyde
Molecular Formula: C8H8O3
Formula Weight: 152.15
MP: 41-43 °C(lit.)
Density: 1.231 g/cm3
Boiling Point: 271.5 °C at 760 mmHg
Flash Point: 112.1 °C
Vapour Pressure: 0.00387 mmHg at 25°C
Index of Refraction: 1.587
Sensitive : Air Sensitive
Physical State: Solid
Color: slightly beige
Product Categories: FINE Chemical & INTERMEDIATES; Aromatic Aldehydes & Derivatives (substituted); Benzaldehyde
Uses
Benzaldehyde,2-hydroxy-4-methoxy- (CAS NO.673-22-3) is used as pharmaceutical intermediate.
Toxicity Data With Reference
| 1. | sce-hmn:lyms 500 µmol/L | MUREAV Mutation Research. 206 (1988),17. |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Safety: CAUTION: May irritate eyes, skin, and respiratory tract
Hazard Codes : Xi (Irritant)
Risk Statements : 36/37/38 (Irritating to eyes, respiratory system and skin)
Safety Statements : 26-36-24/25 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice; Wear suitable protective clothing; Avoid contact with skin and eyes)
WGK Germany : 3
RTECS : BZ2810000
F : 10 (Keep under argon)
Hazard Note : Irritant
HS Code : 29124900
Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating vapors.