- Synthesis method of high-purity lornoxicam
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The invention belongs to the technical field of medicine synthesis, and particularly relates to a synthesis method of high-purity lornoxicam. The method comprises the following steps: by taking 6-chloro-4-hydroxy-2-methyl-2-H-thieno [2, 3-e]-1, 2-thiazine carboxylic acid methyl ester-1, 1-dioxide and 2-aminopyridine as raw materials and xylene as a solvent, carrying out distillation reaction, condensing mixed gas obtained by the distillation reaction to obtain condensate, adsorbing methanol in the condensate by adopting a solid acid catalyst, and recycling the adsorbed condensate. According to the invention, the methanol generated by the reaction is distilled out so as to promote the reaction to proceed forwards, and then the methanol is absorbed under the catalysis of H2SO4/MxOy superacid solid acid, so that the xylene returned to the reaction system does not contain methanol, and the coking of the reaction is reduced so as to improve the product quality and yield; and the purity of the prepared lornoxicam is high and can reach 99.9% or above, the solvent amount is reduced, and the method is suitable for industrial production.
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Paragraph 0038-0062
(2021/10/11)
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- Preparation method of non-steroidal anti-inflammatory analgesic lornoxicam
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The invention discloses a preparation method of non-steroidal anti-inflammatory analgesic lornoxicam. The preparation method includes the steps of enabling 5-chloro-3-chlorosulfonyl-2-methyl carbonate as a starting material to react with 2-N-methyl-2-N-Boc-acetyl(2-pyridyl)amine, and enabling a reactant to react with tertiary butanol and potassium tert-butoxide to obtain the lornoxicam. The preparation method has the advantages of safety, short synthesis route, high yield and environmental protection, and is suitable for industrialized production.
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Paragraph 0026; 0027
(2017/07/20)
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