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Basic Information
CAS No.: 75-43-4
Name: Dichloromonofluoromethane
Molecular Structure:
Molecular Structure of 75-43-4 (Dichloromonofluoromethane)
Formula: CHCl2F
Molecular Weight: 102.923
Synonyms: AF 22;AF22 (fluorocarbon);Algofrene Type 5;Arcton 7;CFC 21;Dichlorofluoromethane;Dichloromonofluoromethane;F 21;F 21 (fluorocarbon);FC 21;Fluorocarbon-21;Fluorodichloromethane;Freon 21;Genetron 21;HCFC 21;Monofluorodichloromethane;R 21;R 21 (refrigerant);
EINECS: 200-869-8
Density: 1.397 g/cm3
Melting Point: -135 °C
Boiling Point: 8.9 °C at 760 mmHg
Flash Point: 130-132°C/3mm
Solubility: Slightly soluble in water
Appearance: COLOURLESS GAS OR COMPRESSED LIQUEFIED GAS, WITH CHARACTERISTIC ODOUR.
Hazard Symbols: DangerousN
Risk Codes: 59
Safety: 59
PSA: 0.00000
LogP: 1.71710
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Synthetic route
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1,1-dichloroperfluoro-2-butanone

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75-43-4

Dichlorofluoromethane

B

141-53-7

sodium formate

C

378-77-8

sodium pentafluoropropionate

Conditions
ConditionsYield
With sodium hydroxide In water Product distribution;A 33.5%
B n/a
C 84.5%
...Expand
75-69-4

trichlorofluoromethane

75-43-4

Dichlorofluoromethane

Conditions
ConditionsYield
With N,N,N,N,N,N-hexamethylphosphoric triamide In N,N-dimethyl-formamide at 20℃; for 0.5h;20%
With ruthenium(II) bis(triphenylphosphine) dichloride; hydrogen In ethanol; toluene at 25℃; for 12h; Product distribution; also carbon tetrachloride; also in the presence of RuCl2(dppe)2 or RuHCl(PPh3)2; other solvents; var. time and temp.;
titanium pH=7; Kinetics;
With formate; titanium(IV) oxide In various solvent(s) at 23℃; for 1h; pH=5.9; Kinetics; Further Variations:; pH-values; Irradiation;
75-09-2

dichloromethane

75-43-4

Dichlorofluoromethane

Conditions
ConditionsYield
With uranium hexafluoride
With hydrogen fluoride; lithium fluoride at 0℃;
67-66-3

chloroform

75-43-4

Dichlorofluoromethane

Conditions
ConditionsYield
With antimonypentachloride; antimony(III) fluoride unter Druck;
With hydrogen fluoride; antimonypentachloride; antimony(III) chloride
With hydrogen fluoride; titanium(IV) fluoride at 127℃;
75-09-2

dichloromethane

A

75-10-5

Difluoromethane

B

593-70-4

R32

C

75-45-6

Chlorodifluoromethane

D

75-43-4

Dichlorofluoromethane

E

75-71-8

Dichlorodifluoromethane

F

75-69-4

trichlorofluoromethane

Conditions
ConditionsYield
With xenon difluoride for 48h; Ambient temperature; other halogenocarbons; var. reaction time;
...Expand
75-45-6

Chlorodifluoromethane

A

75-46-7

trifluoromethan

B

75-43-4

Dichlorofluoromethane

C

67-66-3

chloroform

Conditions
ConditionsYield
zinc aluminate at 300℃; Product distribution; other temperature;
...Expand
67-66-3

chloroform

A

75-46-7

trifluoromethan

B

75-45-6

Chlorodifluoromethane

C

75-43-4

Dichlorofluoromethane

Conditions
ConditionsYield
With antimony tetrachloride fluoride at 100℃; Kinetics; Product distribution; kinetic behaviour of different fluorinated antimony compound in fluorination (SbCl4F, SbCl5 + SbF3Cl2, SbCl5 + SbF5, SbCl5 + SbF3) at different reaction times;
With antimony tetrachloride fluoride at 100℃; under 7600 Torr; Kinetics; Product distribution; Equilibrium constant; kinetic at three different temperatures (85, 100, 115 deg C) and at different pressures ( 7.3, 8.0, 10.0, 10.5, 13.0, 13.8 atm);
With hydrogen fluoride; antimonypentachloride at 70 - 90℃; under 10746.4 - 10953.3 Torr; Product distribution / selectivity; Heating / reflux;
...Expand
70393-08-7

(dichloro-fluoro-methyl)-tris-dimethylamino-phosphonium; chloride

A

75-43-4

Dichlorofluoromethane

B

75-69-4

trichlorofluoromethane

C

353-58-2

bromodichlorofluoromethane

D

353-55-9

dibromochlorofluoromethane

Conditions
ConditionsYield
With potassium fluoride; bromine In various solvent(s)A 25 % Spectr.
B 15 % Spectr.
C 42 % Spectr.
D 5 % Spectr.
...Expand
75-09-2

dichloromethane

A

75-10-5

Difluoromethane

B

593-70-4

R32

C

75-45-6

Chlorodifluoromethane

D

75-43-4

Dichlorofluoromethane

E

75-71-8

Dichlorodifluoromethane

Conditions
ConditionsYield
With osmium pentafluoride oxide Product distribution; other transition-metal oxide fluorides;
...Expand
79-51-6

1,1,3,3-tetrachloro-1,3-difluoro-2-propanone

67-64-1

acetone

A

75-43-4

Dichlorofluoromethane

B

1717-00-6

HCFC-141b

C

75-69-4

trichlorofluoromethane

D

2317-91-1

1-chloro-1-fluoroethane

E

75-35-4

1,1-Dichloroethylene

F

76-12-0

CFC-112a

Conditions
ConditionsYield
With propene; sulphur hexafluoride for 0.5h; Rate constant; Ambient temperature; Irradiation; also with acetone-d6;
...Expand
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Consensus Reports

Reported in EPA TSCA Inventory.

Standards and Recommendations

OSHA PEL: TWA 10 ppm
ACGIH TLV: TWA 10 ppm
DFG MAK: 10 ppm (43 mg/m3)
DOT Classification:  2.2; Label: Nonflammable Gas

Analytical Methods

For occupational chemical analysis use NIOSH: see DICHLOROFLUOROMETHANE, 2516.

Specification

The Dichlorofluoromethane is an organic compound with the formula CHCl2F. The IUPAC name of this chemical is dichloro(fluoro)methane. With the CAS registry number 75-43-4, it is also named as methane, dichlorofluoro-. The product's categories are Refrigerants; Organics. Besides, it should be stored in a cool and ventilated place. It is used as a refrigerant.

Physical properties about Dichlorofluoromethane are: (1)ACD/LogP: 1.40; (2)ACD/LogD (pH 5.5): 1.4; (3)ACD/LogD (pH 7.4): 1.4; (4)ACD/BCF (pH 5.5): 6.83; (5)ACD/BCF (pH 7.4): 6.83; (6)ACD/KOC (pH 5.5): 137.75; (7)ACD/KOC (pH 7.4): 137.75; (8)Index of Refraction: 1.366; (9)Molar Refractivity: 16.5 cm3; (10)Molar Volume: 73.6 cm3; (11)Polarizability: 6.54×10-24cm3; (12)Surface Tension: 19.9 dyne/cm; (13)Density: 1.397 g/cm3; (14)Enthalpy of Vaporization: 24.65 kJ/mol; (15)Boiling Point: 8.9 °C at 760 mmHg; (16)Vapour Pressure: 1340 mmHg at 25°C.

Preparation: this chemical can be prepared by trichloro-fluoro-methane. This reaction will need reagent HMPT and solvent dimethylformamide. The reaction time is 30 min with reaction temperature of 20 °C. The yield is about 20%.



Uses of Dichlorofluoromethane: it can be used to produce 7-chlor-7-fluor-1-methylbicyclo[4.1.0]heptan . It will need reagent 55percent KOH, 18-crown-6 with reaction time of 1 hour. The yield is about 80%.

You can still convert the following datas into molecular structure:
(1)SMILES: ClC(Cl)F
(2)InChI: InChI=1/CHCl2F/c2-1(3)4/h1H
(3)InChIKey: UMNKXPULIDJLSU-UHFFFAOYAU
(4)Std. InChI: InChI=1S/CHCl2F/c2-1(3)4/h1H
(5)Std. InChIKey: UMNKXPULIDJLSU-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LCLo inhalation 10pph/1H (100000ppm)   Fluorine Chemistry Reviews. Vol. 1, Pg. 197, 1967.
mouse LC50 inhalation > 800gm/m3/2H (800000mg/m3) BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 20(11), Pg. 38, 1976.
rat LC50 inhalation 49900ppm/4H (49900ppm)   "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986Vol. 5, Pg. 187, 1986.