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| CAS No.: | 75-10-5 |
|---|---|
| Name: | Difluoromethane |
| Article Data: | 117 |
| Molecular Structure: | |
|
|
|
| Formula: | CH2F2 |
| Molecular Weight: | 52.0237 |
| Synonyms: | Difluoromethane;Ecolo Ace 32;F 32;FC 32;Freon 32;Genetron 32;HFA 32;HFC 32;Methylenedifluoride;R 32;R 32 (refrigerant); |
| EINECS: | 200-839-4 |
| Density: | 0.929 g/cm3 |
| Melting Point: | -136 °C(lit.) |
| Boiling Point: | −51.6°C(lit.) |
| Solubility: | Insoluble in water |
| Appearance: | colorless odorless gas |
| Hazard Symbols: |
 F
|
| Risk Codes: | 11 |
| Safety: | 9-16-33 |
| Transport Information: | UN 3252 |
| PSA: | 0.00000 |
| LogP: | 0.88290 |
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1,1,1,2-tetrafluoroethane
A
- 354-33-6
1,1,1,2,2-pentafluoroethane
B
- 75-10-5
Difluoromethane
C
- 75-46-7
trifluoromethan
D
- 76-16-4
Hexafluoroethane
| Conditions | Yield |
|---|---|
| With fluorine at 200 - 250℃; Product distribution; Further Variations:; Reagents; | A 1.1% B 0.9% C 0.4% D 97.6% |
- 75-09-2
dichloromethane
A
- 74-87-3
methylene chloride
B
- 75-10-5
Difluoromethane
C
- 593-70-4
R32
D
- 75-46-7
trifluoromethan
| Conditions | Yield |
|---|---|
| With hydrogen fluoride; antimony(III) fluoride; antimony pentafluoride at 5 - 100℃; under 12504.7 Torr; | A n/a B 96.9% C 3.08% D n/a |
| antimony pentafluoride | A n/a B 96.4% C 3.56% D n/a |
| Conditions | Yield |
|---|---|
| With ammonium persulfate; ammonium formate In N,N-dimethyl-formamide at 30 - 40℃; | 90% |
- 75-09-2
dichloromethane
- 7664-41-7
ammonia
A
- 74-90-8
hydrogen cyanide
B
- 75-10-5
Difluoromethane
C
- 75-45-6
Chlorodifluoromethane
D
- 124-38-9
carbon dioxide
E
- 201230-82-2
carbon monoxide
| Conditions | Yield |
|---|---|
| nickel titanate In neat (no solvent) steady-state flow reaction over NiTO3*6H2O catalyst at 773 K, further by-product is CFH3 (yield 0.3 %); | A 81.8% B 0.1% C 0.6% D 10.4% E 6.8% |
| nickel titanate In neat (no solvent) steady-state flow reaction over NiTO3*6H2O catalyst at 823 K, further by-product is CFH3 (yield 0.4 %); | A 66.2% B 0.2% C 1.4% D 12.9% E 18.8% |
| With catalyst: Pt/C In neat (no solvent) steady-state flow reaction over Pt/C catalyst at 821 K, a further by-product is CFH3 (yield 0.2 %); | A 64.6% B 0.3% C 0.2% D 0.6% E 0.8% |
| Conditions | Yield |
|---|---|
| Stage #1: With hydrogen fluoride; chromia-alumina catalyst at 100 - 400℃; for 24h; Stage #2: dichloromethane With hydrogen fluoride at 250 - 275℃; Conversion of starting material; | A 79.6% B 7.79% |
| With (PPh3)2Pd(Ph)F; bis(triphenylphosphine)iminium chloride for 0.583333h; | |
| With (PPh3)2Pd(Ph)F; bis(triphenylphosphine)iminium chloride for 0.583333h; Product distribution; other time; |
| Conditions | Yield |
|---|---|
| With dibromobis(triphenylphosphine)nickel(II); potassium carbonate In tetrahydrofuran at 80℃; for 17h; Schlenk technique; Inert atmosphere; Sealed tube; | A 63% B 16% |
| Conditions | Yield |
|---|---|
| With triphenylphosphine In N,N-dimethyl-formamide at 130℃; | 60% |
- 75-09-2
dichloromethane
- 7664-41-7
ammonia
A
- 74-90-8
hydrogen cyanide
B
- 593-53-3
Methyl fluoride
C
- 75-10-5
Difluoromethane
D
- 75-45-6
Chlorodifluoromethane
E
- 124-38-9
carbon dioxide
| Conditions | Yield |
|---|---|
| With catalyst: Pt/C In neat (no solvent) steady-state flow reaction over Pt/C catalyst at 769 K; | A 53.4% B 0.3% C 0.5% D 7.6% E 0.5% |
| Conditions | Yield |
|---|---|
| With potassium fluoride In ethylene glycol at 140 - 150℃; for 5h; | A n/a B 33% |
- 75-43-4
Dichlorofluoromethane
- 1188-14-3
Triethylgerman
A
- 75-10-5
Difluoromethane
B
- 75-09-2
dichloromethane
C
- 75-46-7
trifluoromethan
D
- 75-45-6
Chlorodifluoromethane
E
- 994-28-5
triethylchlorogermane
| Conditions | Yield |
|---|---|
| With ACF. Et3GeH at 25℃; for 72h; Schlenk technique; Inert atmosphere; | A n/a B n/a C 22% D 16% E n/a |
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Specification
The CAS register number of Methylene difluoride is 52727-23-8. It also can be called as Methane, difluoro- and the IUPAC name about this chemical is difluoromethane. The molecular formula about this chemical is CH2F2 and the molecular weight is 52.02. It belongs to the following product categories, such as Refrigerants; Refrigerant and so on. This chemical is a colorless odorless gas, it insoluble in water and it has a high thermal stability. Its vapors are heavier than air. Under prolonged exposure to fire or intense heat the containers may rupture violently and rocket. It contacts with the unconfined liquid can cause frostbite. This chemical can be used as a refrigerant. This chemical is a refrigerant that has zero ozone depletion potential. Methylene difluoride in an azeotropic mixture with pentafluoroethane is known as R-410A, a common replacement for various chlorofluorocarbons in new refrigerant systems.
Physical properties about Methylene difluoride are: (1)ACD/LogP: 0.30; (2)ACD/LogD (pH 5.5): 0.3; (3)ACD/LogD (pH 7.4): 0.3; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 34.85; (7)ACD/KOC (pH 7.4): 34.85; (8)Index of Refraction: 1.195; (9)Molar Refractivity: 7 cm3; (10)Molar Volume: 55.9 cm3; (11)Polarizability: 2.77x10-24cm3; (12)Surface Tension: 6.9 dyne/cm; (13)Enthalpy of Vaporization: 18.9 kJ/mol; (14)Boiling Point: °C at 760 mmHg; (15)Vapour Pressure: 13200 mmHg at 25°C.
The reaction of gas fluorinated can get Methylene difluoride: CH4+2F2→CH2F2+2HF
Another method to produce this chemical is Difluoromethane fluorinated: CH3F+F2→CH2F2+HF
When you are using this chemical, please be cautious about it as the following:
This chemical is highly flammable. When you are using it, please keep away from sources of ignition and take precautionary measures against static discharges. If you want to store it, please keep container in a well-ventilated place.
You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C(F)F
(2)InChI: InChI=1S/CH2F2/c2-1-3/h1H2
(3)InChIKey: RWRIWBAIICGTTQ-UHFFFAOYSA-N
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LC50 | inhalation | 1810gm/m3 (1810000mg/m3) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Toksikologicheskii Vestnik. Vol. (1), Pg. 27, 1996. |
| rat | LC50 | inhalation | 1890gm/m3/4H (1890000mg/m3) | Toksikologicheskii Vestnik. Vol. (3), Pg. 25, 1996. |