CAS No.75-57-0,Tetramethylammonium chloride Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	75-57-0
Name:	Tetramethylammonium chloride
Article Data:	57

Formula:	C₄H₁₂NCl
Molecular Weight:	109.599
Synonyms:	Ammonium,tetramethyl-, chloride (8CI);Methanaminium, N,N,N-trimethyl-, chloride (9CI);Tetramethylammonium chloride (6CI);Tetramine chloride;
EINECS:	200-880-8
Density:	1.17 g/cm³
Melting Point:	>300 °C(lit.)
Boiling Point:	165.26°C (rough estimate)
Solubility:	>60 g/100 mL (20 °C ) in water
Appearance:	white crystals
Hazard Symbols:	T, Xn
Risk Codes:	21-25-36/37/38-20/21/22
Safety:	26-36/37-45-37/39-28A-28-36
Transport Information:	UN 2811 6.1/PG 2
PSA:	0.00000
LogP:	-2.67360

Synthetic route

: 75-59-2
tetramethyl ammoniumhydroxide

: 1605-65-8
N,N,N',N'-Tetramethylphosphorodiamidic chloride

A: 93048-79-4
tetramethylammonium bis(dimethylamino)phosphate

B: 75-57-0
tetramethlyammonium chloride

Conditions

Conditions	Yield
In water for 3h;	A 99.5% B n/a

...Expand

: 593-81-7
trimethylamine hydrochloride

: 616-38-6
carbonic acid dimethyl ester

: 75-57-0
tetramethlyammonium chloride

Conditions

Conditions	Yield
With 1-ethyl-3-methylimidazolium bromide at 169.84℃; for 8h;	99%
With 1-ethyl-3-methylimidazolium bromide at 169.84℃; for 8h;

: 616-38-6
carbonic acid dimethyl ester

: 75-57-0
tetramethlyammonium chloride

Conditions

Conditions	Yield
With ammonium chloride at 169.84℃; for 8h;	96%
With ammonium chloride at 169.84℃; for 8h;	96%

: 98-88-4
benzoyl chloride

: 63581-76-0
dimethyl-amidophosphoric acid monomethyl ester; tetramethylammonium salt

A: 75-57-0
tetramethlyammonium chloride

B: 106997-48-2
C10H14NO4P

Conditions

Conditions	Yield
In acetonitrile for 3h; Ambient temperature;	A n/a B 93%

...Expand

: Hg((2-phenylazo)phenyl)2

: bis(tetramethylammonium) {TlCl5}

: tetramethylammonium trichloro(2-phenylazophenyl)thallate(III)

B: 2N(CH3)4(1+)*Hg2Cl6(2-)=[N(CH3)4]2[Hg2Cl6]

C: 75-57-0
tetramethlyammonium chloride

Conditions

Conditions	Yield
In ethanol refluxing (6 h), solvent evapn. to dryness; residue recrystn. from dichloromethane/diethyl ether; elem. anal.;	A 85% B n/a C n/a

...Expand

: (Me4N)2{Mo3(μ3-S)(μ2-S2)3Cl6}

A: (PPh3)3Mo3(μ3-S)(μ2-S)3Cl4

B: 75-57-0
tetramethlyammonium chloride

C: 3878-45-3
triphenylphosphine sulfide

Conditions

Conditions	Yield
With P(C6H5)3 In methanol Stirring of a suspn. of Mo-compd. and PPh3 (MeOH, 1 h).; Filtn. of pptd. green solid, washing with hot MeOH and benzene, drying (vac.), elem. anal.;	A 82% B n/a C >99

...Expand

: Hg(2-dimethylaminomethylphenyl-C'N)2

: bis(tetramethylammonium) {TlCl5}

A: tetramethylammonium trichloro(2-dimethylaminomethylphenyl-C'N)thallate(III)

B: 2N(CH3)4(1+)*Hg2Cl6(2-)=[N(CH3)4]2[Hg2Cl6]

C: 75-57-0
tetramethlyammonium chloride

Conditions

Conditions	Yield
In ethanol refluxing (6 h), solvent evapn. to dryness; residue recrystn. from dichloromethane/diethyl ether; elem. anal.;	A 77% B n/a C n/a

...Expand

: 31117-16-5
nido-B10H12CNMe3

: 7646-69-7
sodium hydride

: 75-57-0
tetramethlyammonium chloride

Conditions

Conditions	Yield
In tetrahydrofuran at 25°C;	60%

: (Me4N)2{Mo3(μ3-S)(μ2-S2)3Cl6}

A: Mo3(μ3-S)(μ2-S)3(dppe)3Cl4

B: 75-57-0
tetramethlyammonium chloride

Conditions

Conditions	Yield
With C2H4(P2(C6H5)4) In methanol byproducts: (dppe)S2; Boiling of Mo-compd. with dppe (MeOH, 1 h).; Recrystn. of bright green ppt. from a CH2Cl2/hexane mixt., elem. anal.;	A 51% B n/a

: 74-87-3
methylene chloride

: 105334-48-3
Neopentyl N,N,N',N'-tetramethylphosphorodiamidite

A: 75-57-0
tetramethlyammonium chloride

B: Neopentyl N,N-dimethylphosphoramidochloridite

C: bisdimethylamino(methyl)neopentyloxyphosphonium chloride

Conditions

Conditions	Yield
Ambient temperature;	A 10.4% B 17 % Spectr. C 30.1%

...Expand

Raw Materials

13254-33-6

999-77-9

1605-65-8

109-67-1

67-56-1

75-50-3

2344-80-1

122-01-0

Downstream Products

127-19-5

16883-45-7

6971-51-3

120-14-9

463-79-6

553-82-2

75-59-2

62486-66-2

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Consensus Reports

Reported in EPA TSCA Inventory.

Specification

Tetramethyl ammonium chloride, with CAS number of 75-57-0, can be called methanaminium, N,N,N-trimethyl-, chloride (1:1); N,N,N-Trimethylmethanaminium chloride; TMAC. The chemical formula (CH3)4N+Cl- is often abbreviated further as Me4N+Cl-. It is a white crystal. It is a very hygroscopic colourless solid that is soluble in water and polar organic solvents.

Preparation of Tetramethyl ammonium chloride: Tetramethylammonium chloride can be synthesized by the alkylation of ammonium chloride with dimethyl carbonate, in the presence of 1-ethyl-3-methyl imidazolium bromide ([EMIM]+Br-) as an ionic liquid catalyst. The overall reaction is:
NH4+Cl- + 2 (CH₃O)₂CO → N(CH₃)₄+Cl- + 2 H₂O + 2 CO₂

Uses of Tetramethyl ammonium chloride: Tetramethyl ammonium chloride (CAS NO.75-57-0) is used as a phase transfer catalyst for anionic reactants. In small concentrations, also has been shown to enhance yield 5-10 fold at 3M by stabilizing the AT base pairs. Besidea used with polymerase chain reactions to increase yield and specificity.

When you are using this chemical, please be cautious about it as the following:
1. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;
2. Wear suitable protective clothing and gloves;
3. In case of accident or if you feel unwell, seek medical advice immediately (show label where possible);
4. Wear suitable gloves and eye/face protection;
5. After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer);

You can still convert the following datas into molecular structure:
(1)InChI=1S/C4H12N.ClH/c1-5(2,3)4;/h1-4H3;1H/q+1;/p-1;
(2)InChIKey=OKIZCWYLBDKLSU-UHFFFAOYSA-M;
(3)Smiles[N+](C)(C)(C)C.[ClH-];

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
frog	LDLo	subcutaneous	2gm/kg (2000mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) CARDIAC: OTHER CHANGES	Skandinavisches Archiv fuer Physiologie. Vol. 10, Pg. 201, 1900.
guinea pig	LDLo	unreported	20mg/kg (20mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 7, Pg. 183, 1900.
mouse	LD50	intraperitoneal	10mg/kg (10mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	National Technical Information Service. Vol. OTS0536975,
mouse	LD50	subcutaneous	40mg/kg (40mg/kg)		National Technical Information Service. Vol. ORNL-5576,
mouse	LDLo	oral	125mg/kg (125mg/kg)		Journal of Pharmaceutical Sciences. Vol. 69, Pg. 327, 1980.
mouse	LDLo	unreported	20mg/kg (20mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 7, Pg. 183, 1900.
rabbit	LDLo	subcutaneous	6mg/kg (6mg/kg)	VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 7, Pg. 183, 1900.
rat	LD50	intraperitoneal	10mg/kg (10mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION LUNGS, THORAX, OR RESPIRATION: CYANOSIS	National Technical Information Service. Vol. OTS0536975,
rat	LD50	oral	50mg/kg (50mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	National Technical Information Service. Vol. OTS0536975,

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