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| CAS No.: | 75-60-5 | |
|---|---|---|
| Name: | CACODYLIC ACID | |
| Article Data: | 27 | |
| Molecular Structure: | ||
|
|
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| Formula: | C2H7 As O2 | |
| Molecular Weight: | 137.998 | |
| Synonyms: | Arsineoxide, hydroxydimethyl- (7CI,8CI); Arsinic acid, dimethyl- (9CI); Cacodylicacid (6CI); Ansar 138; Arsan; Dimethylarsenic acid; Dimethylarsinic acid;Hydroxydimethylarsine oxide; NSC 103115; NSC 71157; NSC 71158; Phytar; Silvisar510; Sylvicor | |
| EINECS: | 200-883-4 | |
| Density: | >1.1(20oC) | |
| Melting Point: | 195-198 °C | |
| Boiling Point: | 253.1 °C at 760 mmHg | |
| Flash Point: | 109.4 °C | |
| Solubility: |
very solubleStability
Toxicology
|
|
| Appearance: | colorless or white crystalline powder | |
| Hazard Symbols: |
 T N
|
|
| Risk Codes: | 23/25-50/53 | |
| Safety: | Poison by an unspecified route. Moderately toxic by ingestion and intraperitoneal routes. Experimental teratogenic and reproductive effects. A skin and eye irritant. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Used as an herbicide, defoliant, and silvicide. Hazardous when water solution is in contact with active metals, e.g., Fe, Al, Zn. When heated to decomposition it emits toxic fumes of As. See also ARSINE and ARSENIC COMPOUNDS. | |
Analytical Methods: | For occupational chemical analysis use NIOSH: Arsenic, Organo-, 5022. |
|
| Transport Information: | UN 1572 6 | |
| PSA: | 37.30000 | |
| LogP: | 0.11100 | |
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| Conditions | Yield |
|---|---|
| With air | |
| With diethyl ether |
| Conditions | Yield |
|---|---|
| With dihydrogen peroxide |
| Conditions | Yield |
|---|---|
| bei der Oxydation; |
| Conditions | Yield |
|---|---|
| Oxydiert sich an der Luft; | |
| With air | |
| With water; mercury(II) oxide | |
| With water; oxygen |
| Conditions | Yield |
|---|---|
| With diethyl ether |
- 13787-40-1
sodium dimethylarsenide
- 75-60-5
Dimethylarsinic acid
| Conditions | Yield |
|---|---|
| With oxygen In tetrahydrofuran |
- 609-99-4
3,5-dinitrosalicylic acid
- 15132-04-4
cacodylic acid anion
A
- 75-60-5
Dimethylarsinic acid
B
- 52040-82-1
3,5-dinitrosalicylic acid anion
| Conditions | Yield |
|---|---|
| at 25℃; Rate constant; |
- 124-58-3
methylarsonic Acid
- 14031-35-7, 17176-17-9, 29908-03-0, 75044-81-4, 78548-84-2, 79647-17-9, 91279-78-6
S-Adenosyl-L-methionine
- 75-60-5
Dimethylarsinic acid
| Conditions | Yield |
|---|---|
| With GLUTATHIONE; DL-dithiothreitol; magnesium chloride; monomethylarsonic acid methyltransferase from rabbit liver In various solvent(s) at 37℃; for 1.5h; Methylation; Enzymatic reaction; |
- 14031-35-7, 17176-17-9, 29908-03-0, 75044-81-4, 78548-84-2, 79647-17-9, 91279-78-6
S-Adenosyl-L-methionine
A
- 75-60-5
Dimethylarsinic acid
B
- 124-58-3
methylarsonic Acid
| Conditions | Yield |
|---|---|
| With trisodium arsenite; GLUTATHIONE; magnesium chloride; arsenite methyltransferase from rabbit liver In various solvent(s) at 37℃; for 1h; Methylation; Enzymatic reaction; |
- 75-60-5
Dimethylarsinic acid
| Conditions | Yield |
|---|---|
| With sodium hypochlorite; water; oxygen Reagens 4: Aceton; | |
| With iron(III) oxide; water | |
| With sulfuric acid Electrolysis.an Platinelektroden; |
- Total:33 Page 1 of 1 1
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Chemistry
Chemistry informtion about Cacodylic Acid (CAS NO.75-60-5) is:
IUPAC Name: Dimethylarsinic Acid
Synonyms: Ansar(R) ; Cacodylic Acid ; Cacodylie Acid ; Hydroxydimethylarsine Oxide ; Dimethylhydroxyarsine Oxide ; Dimethylarsinic Acid ; Dimethylarsonic Acid ; Silvisar(R)
MF: C2H7AsO2
MW: 138
EINECS: 200-883-4
Melting Point: 195-198 °C
Flash Point: 109.4 °C
Boiling Point: 253.1 °C at 760 mmHg
Vapour Pressure: 0.00288 mmHg at 25°C
Enthalpy of Vaporization: 56.98 kJ/mol
Storage temp.: Store at RT.
Sensitive: Hygroscopic
Merck: 14,1604
BRN: 1736965
Stability: Aqueous solutions react violently with active metals. Incompatible with strong oxidizing agents, strong bases.
Following is the molecular structure of Cacodylic Acid (CAS NO.75-60-5) is:
History
Significant early research into cacodyls was done by Robert Bunsen at the University of Marburg. Bunsen said of the compounds, "the smell of this body produces instantaneous tingling of the hands and feet, and even giddiness and insensibility...It is remarkable that when one is exposed to the smell of these compounds the tongue becomes covered with a black coating, even when no further evil effects are noticeable". His work in this field led to an increased understanding of the methyl radical.
Uses
Derivatives of Cacodylic Acid (CAS NO.75-60-5) , cacodylates , were frequently used as herbicides . For example, "Agent Blue," one of the chemicals used during the Vietnam War, is a mixture of cacodylic acid and sodium cacodylate. Sodium cacodylate is frequently used as a buffering agent in the preparation and fixation of biological samples for transmission electron microscopy.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 500mg/kg (500mg/kg) | National Technical Information Service. Vol. AD295-864, | |
| mouse | LD50 | oral | 1200mg/kg (1200mg/kg) | Journal of Agricultural and Food Chemistry. Vol. 45, Pg. 449, 1997. | |
| mouse | LD50 | unreported | 185mg/kg (185mg/kg) | "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 393, 1971. | |
| rat | LCLo | inhalation | > 2600mg/m3/2H (2600mg/m3) | Toxicology and Applied Pharmacology. Vol. 37, Pg. 165, 1976. | |
| rat | LD50 | oral | 644mg/kg (644mg/kg) | Fundamental and Applied Toxicology. Vol. 7, Pg. 299, 1986. |
Consensus Reports
IARC Cancer Review: Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 23 , 1980,p. 39.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Arsenic and its compounds are on the Community Right-To-Know List. Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
Safety Profile
Poison by an unspecified route. Moderately toxic by ingestion and intraperitoneal routes. Experimental teratogenic and reproductive effects. A skin and eye irritant. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Used as an herbicide, defoliant, and silvicide. Hazardous when water solution is in contact with active metals, e.g., Fe, Al, Zn. When heated to decomposition it emits toxic fumes of As. See also ARSINE and ARSENIC COMPOUNDS.
Hazard Codes:
T: Toxic
N: Dangerous for the environment
Risk Statements:
R23/25: Toxic by inhalation and if swallowed.
R50/53: Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements:
S20/21: When using, do not eat or drink and do not smoke.
S28: After contact with skin, wash immediately with plenty of soap-suds.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S60: This material and its container must be disposed of as hazardous waste.
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR: UN 1572 6.1/PG 2
WGK Germany: 3
RTECS: CH7525000
F:
F 3: Hygroscopic.
F 10: Keep under argon.
HazardClass: 6.1
PackingGroup: II
Standards and Recommendations
OSHA PEL: TWA 0.5 mg(As)/m3
ACGIH TLV: BEI: 35 µ (As)/L inorganic arsenic and methylated metabolites in urine
DOT Classification: 6.1; Label: Poison
Analytical Methods
For occupational chemical analysis use NIOSH: Arsenic, Organo-, 5022.
Specification
General description about Cacodylic Acid (CAS NO.75-60-5) , it is a colorless, odorless crystalline solid.Toxic by ingestion and irritating to skin and eyes.
Air & Water Reactions: Hygroscopic. Water soluble.
Reactivity Profile: It is a weak acid. Dissolves in water to yield solutions containing more hydrogen ions than pure water contains and so having a pH less than 7.0. Is neutralized exothermically by all bases to produce water plus a salt. Reacts (but usually slowly) with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for the solid acid but are quite slow if the solid acid remains dry. The solid may absorb enough water from the air and dissolve sufficiently in it to corrode or dissolve iron, steel, and aluminum parts and containers. Reacts with cyanide salts to generate gaseous hydrogen cyanide. Flammable and/or toxic gases and heat may be generated with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Also may react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still some heat. Can be oxidized exothermically by strong oxidizing agents and reduced by strong reducing agents; a wide variety of products is possible. May initiate polymerization reactions; may catalyze (increase the rate of) chemical reactions.
Health Hazard: Chemical is essentially non-irritating in contact with skin or eyes. Ingestion causes arsenic poisoning, but symptoms are delayed.
Fire Hazard: Behavior in Fire: May form toxic oxides of arsenic when heated.