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CAS No.: | 75-86-5 |
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Name: | 2-Hydroxy-2-methylpropanenitrile |
Article Data: | 63 |
Molecular Structure: | |
Formula: | C4H7NO |
Molecular Weight: | 85.1057 |
Synonyms: | Lactonitrile,2-methyl- (6CI,8CI);2-Cyano-2-hydroxypropane;2-Cyano-2-propanol;2-Hydroxy-2-cyanopropane;2-Hydroxy-2-methylpropanenitrile;2-Hydroxy-2-methylpropionitrile;2-Hydroxyisobutyronitrile;2-Methyl-2-hydroxypropionitrile;2-Methyllactonitrile;2-Propanone,cyanohydrin;Acetone cyanohydrin;Dimethyl ketone cyanohydrin;NSC 131093;NSC7080;NSC 977;a-Hydroxyisobutyronitrile; |
EINECS: | 200-909-4 |
Density: | 0.932 |
Melting Point: | -19ºC |
Boiling Point: | 82ºC |
Flash Point: | 73 ºC |
Solubility: | miscible |
Appearance: | yellowish liquid |
Hazard Symbols: | |
Risk Codes: | R26/27/28;R50 |
Transport Information: | UN 1541 |
PSA: | 44.02000 |
LogP: | 0.28088 |
Conditions | Yield |
---|---|
With acetic acid In water at 30℃; Microreactor technology; Continuous flow system; | 99% |
With sodium metabisulfite In water at 20℃; for 0.5h; | |
Stage #1: acetone With sodium hydrogen sulfite In water at 0℃; for 1h; Stage #2: potassium cyanide In water for 14h; |
Conditions | Yield |
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With sodium hydroxide; sulfuric acid; sodium cyanide In water at 10℃; for 1.5h; pH=7.3; | 95% |
With pyridine | |
With quinoline |
2-amino-2-cyanopropane
A
2-cyano-2-nitropropane
B
1-cyano-1-methylethylnitrate
C
tris-(1-cyano-1-methyl-ethyl)-hydroxylamine
D
2-hydroxy-2-methylpropanenitrile
Conditions | Yield |
---|---|
With perchloric acid; sodium nitrite at 25℃; Product distribution; var. α-aminonitriles; other conditions, also radical scavengers; | A 47.4% B 0.4% C 13.9% D 37.3% |
Conditions | Yield |
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With sulfuric acid In water at 20℃; | 29% |
Conditions | Yield |
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With aluminum oxide at 150 - 300℃; Beim Leiten von Aceton-Dampf im den Gemisch; | |
With dipotassium hydrogenphosphate; kieselguhr at 60℃; Beim Leiten von Aceton-Dampf im den Gemisch; |
Conditions | Yield |
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at 20℃; Kinetics; Verlauf der Reaktion; auch in anderen Loesungsmitteln; | |
at 20℃; Rate constant; und in anderen Loesungsmitteln; |
1. | orl-rat LD50:19,300 µg/kg | GISAAA Gigiena i Sanitariya. 58 (1)(1993),28. | ||
2. | ihl-rat LCLo:63 ppm/4H | AIHAAP American Industrial Hygiene Association Journal. 23 (1962),95. | ||
3. | scu-rat LDLo:8500 µg/kg | BJIMAG British Journal of Industrial Medicine. 19 (1962),283. | ||
4. | orl-mus LD50:14 mg/kg | 28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,161. | ||
5. | ihl-mus LCLo:500 mg/m3/2H | IGIBA5 Igiena. 11 (1962),27. | ||
6. | ipr-mus LD50:1 mg/kg | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) No. AD277-689 . | ||
7. | orl-rbt LD50:13,500 µg/kg | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) No. PB214-270 . | ||
8. | skn-rbt LD50:17 mg/kg | AIHAAP American Industrial Hygiene Association Journal. 23 (1962),95. | ||
9. | unr-rat TDLo:242 mg/kg/26W-I | GISAAA Gigiena i Sanitariya. 31 (6)(1966),8. | ||
10. |