Name: TRIMETHYLSILANE
SKU: 993-07-7

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Pharmaceutical (42)
Organic Chemicals (13)
Others (9)
Materials (3)
Reagent (2)

Basic Information

Molecular Structure:
CAS No.:	993-07-7
Name:	TRIMETHYLSILANE

Formula:	C₃H₁₀Si
Molecular Weight:	74.1979
Synonyms:	2-Methyl-2-silapropane;Dow Corning 9-5170;Trimethylsilyl hydride;
EINECS:	213-603-0
Density:	0.638 g/cm³
Melting Point:	-135,9 °C
Boiling Point:	1.67 °C at 760 mmHg
Flash Point:	-72.532 °C
Solubility:	1.4g/L at 20℃
Risk Codes:	12-36/37/38
Safety:	9-16-26-33
PSA:	0.00000
LogP:	1.10290

Synthetic route

: 16853-85-3
lithium aluminium tetrahydride

: 75-77-4
chloro-trimethyl-silane

: 993-07-7
trimethylsilan

Conditions

Conditions	Yield
aluminum (III) chloride; lithium chloride In xylene at 80℃; for 0.166667h; Product distribution / selectivity;	95.4%
In toluene at 80℃; for 0.166667h; Product distribution / selectivity;	92.5%
lithium tetrachloroaluminate In toluene at 80℃; for 0.166667h; Product distribution / selectivity;	92.7%

: 6651-36-1
1-(Trimethylsilyloxy)cyclohexene

A: 993-07-7
trimethylsilan

B: 108-94-1
cyclohexanone

Conditions

Conditions	Yield
With hydrogen; [RuCl(η2-H2)(dppe)2]OTf In 1,2-dichloro-ethane at 50℃; under 760 Torr; for 48h; Product distribution; Further Variations:; Catalysts;	A n/a B 95%
With hydrogen; [RuCl(dppe)2]OTf In benzene-d6 at 50℃; for 3h; Hydrogenolysis; Title compound not separated from byproducts;

: 27607-77-8
trimethylsilyl trifluoromethanesulfonate

: 993-07-7
trimethylsilan

Conditions

Conditions	Yield
With C35H37IrN2P(1+)*C24BF20(1-); hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine In (2)H8-toluene at 20℃; under 760.051 Torr; for 4.5h;	94%
With [N-[4-(dimethylamino)phenyl]-2-pyridinecarboxamidato](pentamethylcyclopentadienyl)iridium trifluorometanesulfonate; hydrogen; N-ethyl-N,N-diisopropylamine In benzene-d6 at -196 - 60℃; under 3040.2 Torr; for 48h;	95 %Spectr.
With 1,4-bis-(trimethylsilyl)benzene; [N-[4-(dimethylamino)phenyl]-2-pyridinecarboxamidato](pentamethylcyclopentadienyl)iridium trifluorometanesulfonate; hydrogen; N-ethyl-N,N-diisopropylamine In benzene-d6 at 60℃; under 3040.2 Torr; for 48h; Reagent/catalyst;	95 %Spectr.
With [Ru(H)2CO(HN(CH2CH2P(iPr)2)2)]; hydrogen; triethylamine In benzene-d6 at 20℃; under 3000.3 Torr; for 18h; Catalytic behavior; Pressure;	85 %Spectr.

: 75-77-4
chloro-trimethyl-silane

: 993-07-7
trimethylsilan

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; calcium hydride In diethylene glycol dimethyl ether for 11h; Inert atmosphere; Reflux;	92%
With lithium aluminium tetrahydride In toluene at 80℃; for 0.916667h; Inert atmosphere;	82%
With lithium aluminium tetrahydride In hexane at 40℃; for 3h; Irradiation; ultrasonic irradiation;	80%

: 83268-94-4
C10H26OSi3

A: 6224-91-5
trimethyl(prop-1-ynyl)silane

B: 993-07-7
trimethylsilan

C: 1825-61-2
Methoxytrimethylsilane

D: 754-05-2
ethenyltrimethylsilane

Conditions

Conditions	Yield
at 650℃; under 0.0001 Torr;	A 18% B n/a C 87% D 28%

...Expand

: 814-98-2
1,1,2,2-tetramethyldisilane

A: 75-77-4
chloro-trimethyl-silane

B: 1066-35-9
dimethylmonochlorosilane

C: 1111-74-6
dimethylsilane

D: 993-07-7
trimethylsilan

Conditions

Conditions	Yield
With tetra-n-butylphosphonium chloride at 180℃; for 17h; Sealed tube;	A 2% B 4% C 87% D 7%

...Expand

: 1560-28-7
pentamethylchlorodisilane

A: 75-77-4
chloro-trimethyl-silane

B: 993-07-7
trimethylsilan

Conditions

Conditions	Yield
With 2-methylimidazole; tetra-n-butylphosphonium chloride at 175℃; for 89h; Sealed tube;	A 85% B 11%

: 766-77-8
Dimethylphenylsilane

: 17961-91-0
3-dimethylaminophenyl-trimethylsilane

A: 993-07-7
trimethylsilan

B: 3-(dimethyl(phenyl)silyl)-N,N-dimethylaniline

Conditions

Conditions	Yield
With tris(pentafluorophenyl)borate In chlorobenzene at 100℃; for 24h; Mechanism; Glovebox; Inert atmosphere; chemoselective reaction;	A n/a B 81%

...Expand

: 3-(dimethylsilyl)-N,N-dimethylaniline

A: 993-07-7
trimethylsilan

B: 3,3′-(dimethylsilanediyl)-bis(N,N-dimethylaniline)

Conditions

Conditions	Yield
With trimethylphenylsilane; tris(pentafluorophenyl)borate In chlorobenzene at 100℃; for 24h; Mechanism; Glovebox; chemoselective reaction;	A n/a B 78%