1563-56-0Relevant articles and documents
Spectrophotometric determination of bromazepam
Fukumoto
, p. 3678 - 3681 (1980)
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Synthesis of 1,5-substituted iminodibenzo[b,f][1,5]diazocine, an analogue of Troeger's Base
Leganza, Alessandro,Bezze, Chiara,Zonta, Cristiano,Fabris, Fabrizio,De Lucchi, Ottorino,Linden, Anthony
, p. 2987 - 2990 (2006)
A method for the synthesis of 1,5-disubstituted iminodibenzo[b,f][1,5] diazocines is presented. The synthesis is achieved by the metal-free cyclization of 2-aminophenyl ketimines using the corresponding 2-aminophenyl ketone as the catalyst. The synthesis gives new insight into the mechanism of formation of this class of compounds. The presence of potential sites for hydrogen-bond formation and two aromatic bromine atoms available for functionalization make these targets attractive for further development in supramolecular chemistry. The structure of the complex derived from the iminodibenzo[b,f][1,5]diazocine and PdCl2 was determined by X-ray crystallography. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.
Stability indicating spectrophotometric methods for quantitative determination of bromazepam and its degradation product
A. Ali, Nesma,Abdelrahman, Maha M.,Al-Hossaini, Abdullah M.,Darwish, Hany W.,El Ghobashy, Mohamed R.,Naguib, Ibrahim A.
, (2020)
Four simple, sensitive and selective stability indicating spectrophotometric methods are presented for quantitative determination of the benzodiazepine drug; bromazepam (BMZ) and one of its reported potential impurities and degradation product; 2-(2-amino-5-bromobenzoyl) pyridine (ABP) in methanol. Method A, is isoabsorptive point coupled with D0 method, where good linearity was obtained by measuring the absorbance of BMZ at 264 nm (Aiso) in the concentration range of 2–25 μg mL?1, and the absorbance of ABP at its λmax 396 nm in concentration range of 0.5–24 μg mL?1. Method B, is ratio subtraction; the absorbance was measured at 233 nm for BMZ using 20 μg mL?1 of ABP, while ABP was determined directly at its λmax 396 nm using methanol as a solvent. Method C, was based on measuring the total peak amplitude of the first derivative of the ratio spectra (DD1) of BMZ from 301 to 326 nm using 10 μg mL?1 of ABP as a divisor and determination of ABP at peak amplitude of 293 nm using 5 μg mL?1 of BMZ as a divisor. In method D, ratio difference method, good linearity was achieved for determination of BMZ and ABP by measuring the differences between the amplitudes of ratio spectra at 312 nm and 274 nm and differences between the amplitudes of ratio spectra at 274 nm and 312 nm, respectively. The stability of BMZ was investigated under different ICH recommended forced degradation conditions. The suggested methods were then successfully applied for determination of BMZ in its pharmaceutical formulations.
Preparation method of benzodiazepine derivatives
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Paragraph 0050-0051; 0075; 0076; 0077-0079, (2018/07/30)
The invention relates to a preparation method of benzodiazepine derivatives. The preparation method comprises preparing a compound shown in the formula (III) from a compound shown in the formula (V),preparing a compound shown in the formula (II) through a reaction and finally preparing benzodiazepine derivatives shown in the formula (I) and their pharmaceutically acceptable salts. The invention also discloses an intermediate in the preparation process and a preparation method thereof. The preparation method shortens the reaction processes, improves the reaction yield, is simple, is easy to operate and control and is conducive to expanded production.
DIHYDROQUINAZOLINONE ANALOGUES
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Paragraph 0303-0306, (2014/10/16)
The present invention encompasses compounds of general formula (I) wherein the groups R1 to R4 and A1 to A5 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament.
