1671-49-4Relevant articles and documents
Selective synthesis of sulfoxides and sulfonesviacontrollable oxidation of sulfides withN-fluorobenzenesulfonimide
Cao, Zhong-Yan,Li, Xiaolong,Lu, Hao,Wang, Panpan,Wang, Shengqiang,Xu, Xiaobo,Yan, Leyu,Yang, A-Xiu
supporting information, p. 8691 - 8695 (2021/10/22)
A practical and mild method for the switchable synthesis of sulfoxides or sulfonesviaselective oxidation of sulfides using cheapN-fluorobenzenesulfonimide (NFSI) as the oxidant has been developed. These highly chemoselective transformations were simply achieved by varying the NFSI loading with H2O as the green solvent and oxygen source without any additives. The good functional group tolerance makes the strategy valuable.
Device and method for fully continuously synthesizing 2-nitro-4-methylsulfonylbenzoic acid from 4-methylsulfonyltoluene
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Paragraph 0090-0112, (2021/02/10)
The invention discloses a device for fully continuously synthesizing 2-nitro-4-methylsulfonylbenzoic acid from 4-methylsulfonyltoluene. The device comprises a first storage tank, a second storage tank, a first metering pump, a second metering pump, a first tubular reactor, a second tubular reactor and a collecting kettle. The first storage tank is communicated with a first metering pump, the firstmetering pump is communicated with a first tubular reactor, the first tubular reactor is communicated with a three-way mixer, the first tubular reactor is communicated with the three-way mixer, the second metering pump is communicated with the three-way mixer, the three-way mixer is communicated with a second tubular reactor, and the second tubular reactor is communicated with the collecting kettle. The device also comprises a waste gas absorption kettle communicated with the collecting kettle. The invention also discloses a method for synthesizing 2-nitro-4methylsulfonylbenzoic acid by adopting a tubular reaction mode based on the device. According to the device design and the method based on the device, the target product is synthesized in a tubular reaction mode, and the technical defects that waste acid is difficult to recycle and the pollution amount is large in existing kettle type preparation are overcome.
Method for preparing 2-nitro-4-methylsulfonyltoluene by continuous flow
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Paragraph 0030-0035; 0039-0044, (2019/10/17)
The invention discloses a method for preparing 2-nitro-4-methylsulfonyltoluene by continuous flow. The method comprises conveying 1-methyl-4-(methylsulfonyl)-benzene, sulfuric acid and nitric acid continuously into a channel reactor, and allowing to react so as to continuously prepare 2-nitro-4-methylsulfonyltoluene, wherein the channel reactor comprises a cooling module, a fluid module and an outlet module which are communicated in sequence. The method of the invention has the advantages of high safety, low byproduct output, high product purity and the like, and also has the advantages of good process simplicity, good operational convenience, high automation level, high preparation efficiency and the like; the method of the invention is suitable for large-scale continuous preparation of 2-nitro-4-methylsulfonyltoluene and has good application value and application prospect.