110964-79-9

Basic information

• Product Name: 2-Nitro-4-methylsulfonylbenzoic acid
• Synonyms: RARECHEM AL BE 1440;2-NITRO-4-METHYLSULFONYLBENZOIC ACID;4-METHYLSULPHONYL-2-NITROBENZOIC ACID;4-(METHYLSULFONYL)-2-NITROBENZOIC ACID;O-Nitro-P-Methylsulfonyl Benzoic Acid;4-Methanesulfonyl-2-nitrobenzoic acid;4-Carboxy-3-nitrophenyl methyl sulphone, 2-Carboxy-5-(methylsulphonyl)nitrobenzene;4-(Methylsulfo
• CAS NO: 110964-79-9
• Molecular Formula: C₈H₇NO₆S
• Molecular Weight: 245.21
• EINECS: 1533716-785-6
• Product Categories: intermediate
• Mol File: 110964-79-9.mol
• Article Data: 37

Chemical Properties

• Melting Point: 211-212
• Boiling Point: 497.8 ºC at 760 mmHg
• Flash Point: 254.9 ºC
• Appearance: /
• Density: 1.576
• Vapor Pressure: 9.97E-11mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 1.51±0.25(Predicted)
• CAS DataBase Reference: 2-Nitro-4-methylsulfonylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Nitro-4-methylsulfonylbenzoic acid(110964-79-9)
• EPA Substance Registry System: 2-Nitro-4-methylsulfonylbenzoic acid(110964-79-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 110964-79-9(Hazardous Substances Data)

Usage

Description

2-Nitro-4-methylsulfonylbenzoic acid, also known as 4-Methylsulfonyl-2-nitrobenzoic acid, is a pale yellow solid that serves as a metabolite of Mesotrione. It is a chemical compound with a unique structure that features a nitro group at the 2nd position and a methylsulfonyl group at the 4th position on a benzoic acid backbone.

Uses

Used in Pharmaceutical Industry:
2-Nitro-4-methylsulfonylbenzoic acid is used as an intermediate in the synthesis of pharmaceutical compounds. Its unique chemical structure makes it a valuable building block for the development of new drugs, particularly those targeting specific biological pathways or receptors.
Used in Metabolite Research:
As a metabolite of Mesotrione, 2-Nitro-4-methylsulfonylbenzoic acid is used in the study of the metabolic pathways and pharmacokinetics of this herbicide. Understanding its role in the body can help researchers develop safer and more effective formulations or alternatives.
Used in Chemical Synthesis:
2-Nitro-4-methylsulfonylbenzoic acid can be used as a starting material or a reagent in various chemical synthesis processes. Its distinct functional groups allow for further modification and the creation of a wide range of chemical products with different applications across various industries.
Used in Analytical Chemistry:
The compound can be employed as a reference material or a standard in analytical chemistry for the calibration of instruments and the development of new analytical methods. Its distinct properties make it suitable for use in high-performance liquid chromatography (HPLC), mass spectrometry, and other analytical techniques.

InChI:InChI=1/C8H7NO6S/c1-16(14,15)5-2-3-6(8(10)11)7(4-5)9(12)13/h2-4H,1H3,(H,10,11)

Synthetic route

2-nitro-4-methylsulfonyl benzoic acid dicyclohexyl amine salt → 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
With potassium hydroxide In water pH=13; Reagent/catalyst;	98.45%
With potassium hydroxide In water pH=3 - 13;	44.1 g

1-methyl-4-(methylsulfonyl)-2-nitrobenzene (1671-49-4) → 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
With sulfuric acid; oxygen; nitric acid; vanadia at 140℃; for 11h; Temperature;	98%
With sulfuric acid; oxygen; nitric acid; vanadia at 138 - 140℃; under 37.5038 Torr; Catalytic behavior; Temperature; Autoclave;	96.7%
With oxygen; nitric acid; acetic acid; 2,6-dihydroxypyrrolo[3,4-f]isoindolo-1,3,5,7(2H,6H)tetrone at 150℃; under 37503.8 Torr; for 5h; Catalytic behavior; Reagent/catalyst; Temperature; Pressure; Autoclave;	94.9%

Methyl p-tolyl sulfone (3185-99-7) → 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
Stage #1: Methyl p-tolyl sulfone With nitric acid In dichloromethane at 10℃; Large scale; Stage #2: With vanadium(V) oxide; sulfuric acid at 140℃; Large scale;	98%
Stage #1: Methyl p-tolyl sulfone With sulfuric acid for 4.5h; Large scale; Stage #2: With nitric acid; vanadia In water at 142 - 145℃; for 38.5h; Time; Large scale;	90.2%
Stage #1: Methyl p-tolyl sulfone With sulfuric acid; nitric acid In water for 6.1h; Heating; Industrial scale; Stage #2: With boron nitride; vanadia In water at 142 - 146℃; for 29h; Temperature; Industrial scale;	90.77%

2-nitro-4-methylsulfonyl benzoic acid n-hexylamine salt → 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
With potassium hydroxide In water pH=13; Reagent/catalyst;	98%
With potassium hydroxide In water pH=3 - 13;	86.2 g

methyl 2-cyano-2-(4-(methylsulfonyl)-2-nitrophenyl)acetate → 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
With dihydrogen peroxide; potassium hydroxide In water at 40℃; for 2h;	97%

2-nitro-4-methylsulfonyl benzoic acid n-propylamine salt → 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
With potassium carbonate	96.5%
With potassium carbonate In water Heating; Further stages;	84.9 g

4-(methylsulfonyl)-2-nitrobenzonitrile → 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
With sulfuric acid; acetic acid In water at 100℃; for 6h;	93%

1-methyl-4-(methylsulfonyl)-2-nitrobenzene (1671-49-4) + acetic acid (64-19-7) → 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
With 1,1,2,2-tetrabromoethane; cobalt(II) acetate; manganese(III) triacetate dihydrate In water at 210℃; under 22801.5 Torr; for 3h; Reagent/catalyst; Solvent; Temperature; Pressure; Reflux;	92%

diethyl 2-nitro-4-methanesulfonylphenylmalonate → 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
With dihydrogen peroxide; sodium hydroxide In N,N-dimethyl-formamide at 80℃; for 2h;	88%

2-nitro-4-methylsulfonyl benzoic acid triethylamine salt → 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
With calcium hydroxide In water pH=12 - 13;	87.9%
With calcium hydroxide pH=12 - 13;	18.7 g

sodium bicarbona+and + nitro-4-sulfinylbenzoic acid + 4-chlorosulfonyl-2-nitro-benzoyl chloride (130264-19-6) + sodium monochloroacetic acid (3926-62-3) → 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
With sodium sulfite In water; ethyl acetate	87%

4-chlorosulfonyl-2-nitro-benzoic acid (54090-40-3) + chloroacetic acid (79-11-8) → 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
With sodium hydroxide; sodium hydrogencarbonate; sodium sulfite 1) H2O, 75 deg C, 1 h, 2) 105 deg C, 7 h, 3) reduction temperature 10-15 deg C; Yield given. Multistep reaction;

vanadium(V) oxide (788133-24-4) + 1-methyl-4-(methylsulfonyl)-2-nitrobenzene (1671-49-4) → 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
With nitric acid In sulfuric acid

vanadium(V) oxide (788133-24-4) + Methyl p-tolyl sulfone (3185-99-7) → 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
In sulfuric acid; water

mesotrione (104206-82-8) → 2-amino-4-(methylsulfonyl)benzoic acid (393085-45-5) + 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
With TiO2 Degussa P25; oxygen In water pH=4; Kinetics; Mechanism; Reagent/catalyst; pH-value; Wavelength; UV-irradiation;

mesotrione (104206-82-8) → 2-amino-4-(methylsulfonyl)benzoic acid (393085-45-5) + xanthene-1,9-dione-3,4-dihydro-6-methylsulfonyl + 2-hydroxy-4-(methylsulfonyl)-2-nitrobenzoic acid (108153-42-0) + 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
With water; copper(l) chloride for 24h; pH=6.5; Kinetics; Irradiation;

1-fluoro-4-methanesulfonyl-2-nitrobenzene (453-72-5) + cyanoacetic acid amide (107-91-5) → 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
Stage #1: 1-fluoro-4-methanesulfonyl-2-nitrobenzene; cyanoacetic acid amide With sodium hydroxide In dimethyl sulfoxide at 310℃; for 3h; Stage #2: With dihydrogen peroxide In dimethyl sulfoxide for 3h;	111 g

Cyanoaceton (2469-99-0) + 1-chloro-4-methanesulfonyl-2-nitrobenzene (97-07-4) → 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
Stage #1: Cyanoaceton; 1-chloro-4-methanesulfonyl-2-nitrobenzene With sodium hydroxide In dimethyl sulfoxide at 60℃; for 1h; Stage #2: With dihydrogen peroxide In dimethyl sulfoxide for 2h;	148.6 g

1-methyl-2-nitrobenzene (88-72-2) → 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: chlorosulfonic acid / 3.5 h / 110 - 115 °C 1.2: 3 h / 60 - 65 °C 2.1: sodium sulfite; sodium carbonate / water / 3 h / 0 - 25 °C / pH 7.5 - 8 2.2: 14 h / 40 - 100 °C 3.1: vanadia; nitric acid / 135 - 160 °C View Scheme

4-methyl-3-nitrobenzenesulfonyl chloride (616-83-1) → 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: sodium sulfite; sodium carbonate / water / 3 h / 0 - 25 °C / pH 7.5 - 8 1.2: 14 h / 40 - 100 °C 2.1: vanadia; nitric acid / 135 - 160 °C View Scheme

1-chloro-4-methanesulfonyl-2-nitrobenzene (97-07-4) → 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydroxide / dimethyl sulfoxide / 1 h / 60 °C 2: potassium hydroxide; dihydrogen peroxide / water / 2 h / 40 °C View Scheme

p-toluenesulfonyl chloride (98-59-9) → 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: sodium hydrogencarbonate; sodium sulfite / water / 9 h / 75 °C 1.2: 4.5 h / 45 - 130 °C 2.1: sulfuric acid / 0.5 h / 20 °C 2.2: 10 h / 10 °C 3.1: vanadia; sulfuric acid; nitric acid / 13 h / 145 - 165 °C View Scheme

4-bromoohenyl methyl sulfone (3466-32-8) → 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
Multi-step reaction with 3 steps 1: nitric acid; sulfuric acid / 0.5 h / 0 - 10 °C 2: N,N-dimethyl-formamide / 6 h / 140 °C 3: sulfuric acid; acetic acid / water / 6 h / 100 °C View Scheme

3-nitrophthalic acid (603-11-2) → 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
Multi-step reaction with 4 steps 1: chlorosulfonic acid / dichloromethane / 3 h / 0 - 20 °C 2: sodium carbonate; sodium sulfite / water / 1.5 h / 30 - 105 °C 3: N-benzyl-N,N,N-triethylammonium chloride; sodium hydrogencarbonate / water; N,N-dimethyl-formamide / 10 h / 80 °C 4: copper(I) oxide; triethylamine / 24 h / 50 °C View Scheme

3-nitro-5-sulfonyl chloride phthalic acid → 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium carbonate; sodium sulfite / water / 1.5 h / 30 - 105 °C 2: N-benzyl-N,N,N-triethylammonium chloride; sodium hydrogencarbonate / water; N,N-dimethyl-formamide / 10 h / 80 °C 3: copper(I) oxide; triethylamine / 24 h / 50 °C View Scheme

3-nitro-5-methylsulfonyl phthalic acid → 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9)

Conditions	Yield
With copper(I) oxide; triethylamine at 50℃; for 24h; Reagent/catalyst;	222 g

4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9) → 4-methylsulphonyl-2-nitrobenzoyl chloride (110964-80-2)

Conditions	Yield
With thionyl chloride; N,N-dimethyl-formamide In 1,2-dichloro-ethane at 65 - 69℃; for 6.5h; Inert atmosphere;	98.2%

4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9) + 1,3-dimethyl-1H-pyrazol-5-ol (5203-77-0) → (1,3-dimethyl-5-hydroxypyrazol-4-yl)-(4-methanesulfonyl-2-nitrophenyl)methanone

Conditions	Yield
With triethylamine In 1,4-dioxane at 60℃; for 2h;	97%

4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9) + 1,3-dimethyl-1H-pyrazol-5-ol (5203-77-0) → (1,3-dimethylpyrazole-5-yl methanesulfonate-4-yl)-(4-methanesulfonyl-2-nitrophenyl)methanone

Conditions	Yield
With triethylamine In 1,4-dioxane at 50℃; for 5h;	95%

4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9) → 1-methanesulfonyl-3-nitro-benzene (2976-32-1)

Conditions	Yield
With copper(l) iodide; triethylamine In dimethyl sulfoxide at 120℃; under 760.051 Torr; for 20h; Inert atmosphere; Schlenk technique;	87%

4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9) + 1,3-cylohexanedione (504-02-9) → mesotrione (104206-82-8)

Conditions	Yield
Stage #1: 4-methanesulfonyl-2-nitro-benzoic acid; 1,3-cylohexanedione With dicyclohexyl-carbodiimide In 5,5-dimethyl-1,3-cyclohexadiene at 140 - 150℃; Stage #2: In 5,5-dimethyl-1,3-cyclohexadiene; acetonitrile Solvent;	80.3%

tert-butyl (2S)-amino(cyclohexyl)ethanoate hydrochloride (213475-52-6) + 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9) → 1,1-dimethylethyl (2S)-cyclohexyl-({[4-(methylsulfonyl)-2-nitrophenyl]carbonyl}amino)ethanoate (887243-81-4)

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃;	74%

4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9) + benzene (71-43-2) → 4-methylsulfonyl-2-nitro-1-phenylbenzene

Conditions	Yield
With dipotassium peroxodisulfate; silver sulfate In acetonitrile at 120℃; for 24h; Glovebox; Schlenk technique; Sealed tube; Inert atmosphere;	70%

1,2,4-Triazole (288-88-0) + 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9) → 2-Nitro-4-methanesulphonyl benzoyltriazolamide

Conditions	Yield
With thionyl chloride In N-methyl-acetamide; 5,5-dimethyl-1,3-cyclohexadiene; acetonitrile	56.8%

3-amino-4-methylfurazan (17647-70-0) + 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9) → N-(4-methyl-1,2,5-oxadiazol-3-yl)-4-(methylsulfonyl)-2-nitrobenzamide

Conditions	Yield
With dmap; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In tetrahydrofuran; dichloromethane at 20℃; for 30h;	53%

4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9) → 1-iodo-3-(methylsulfonyl)-5-nitrobenzene (62606-16-0)

Conditions	Yield
With copper(I) oxide; potassium phosphate; bismuth (III) nitrate pentahydrate; palladium(II) trifluoroacetate; oxygen; sodium iodide In dimethyl sulfoxide at 170℃; for 20h; Schlenk technique;	51%
With copper(I) oxide; potassium phosphate; bismuth (III) nitrate pentahydrate; oxygen; palladium diacetate; sodium iodide In dimethyl sulfoxide at 170℃; for 10h; Schlenk technique; Green chemistry; regioselective reaction;	24.4 mg

4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9) → C14H12N2O8S2

Conditions	Yield
With copper(l) iodide In dimethyl sulfoxide at 140℃; for 20h; Inert atmosphere; Molecular sieve;	42%

4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9) → 2-amino-4-(methylsulfonyl)benzoic acid (393085-45-5)

Conditions	Yield
With hydrogenchloride; iron

4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9) → 3-methanesulfonyl-benzo[4,5]thiazolo[2,3-b]quinazolin-12-one

Conditions	Yield
Multi-step reaction with 2 steps 1: iron-powder; aqueous HCl View Scheme

3-chloro-2-cyclohexenone (5682-75-7) + 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9) → 3-(4'-methylsulfonyl-2'-nitro-benzoyloxy)-2-cyclohexene-1-one (226944-49-6)

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; zinc(II) chloride In acetonitrile at 45℃; for 58h; Heating / reflux;
With N-ethyl-N,N-diisopropylamine; zinc(II) chloride In acetonitrile at 45℃; for 58h; Heating / reflux;

1-methyl-8-oxa-bicyclo[3.2.1]oct-6-ene-2,4-dione (872030-70-1) + 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9) → 3-(4-methylsulfonyl-2-nitro-benzoyl)-1-methyl-8-oxa-bicyclo[3.2.1]oct-6-ene-2,4-dione

Conditions	Yield
Stage #1: 1-methyl-8-oxa-bicyclo[3.2.1]oct-6-ene-2,4-dione; 4-methanesulfonyl-2-nitro-benzoic acid With dicyclohexyl-carbodiimide In dichloromethane; acetonitrile at 20℃; for 2.5h; Stage #2: With triethylamine; 2-hydroxy-propionitrile In dichloromethane; acetonitrile at 20℃; for 18h;

4-nitro-phenol (100-02-7) + oxalyl dichloride (79-37-8) + 4-methanesulfonyl-2-nitro-benzoic acid (110964-79-9) → 4-nitrophenyl 2-nitro-4-(methylsulfonyl)benzoate (415955-68-9)

Conditions	Yield
With triethylamine In dichloromethane; N,N-dimethyl-formamide
With triethylamine In dichloromethane; N,N-dimethyl-formamide

Upstream product

• 1671-49-4 1‐methyl‐4‐(methylsulfonyl)‐2‐nitrobenzene 
• 130264-19-6 4-chlorosulfonyl-2-nitro-benzoyl chloride 
• 3926-62-3 sodium monochloroacetic acid 
• 603-11-2 3-nitrophthalic acid 
• 64-19-7 acetic acid 
• 98-59-9 p-toluenesulfonyl chloride 
• 97-07-4 1-chloro-4-methanesulfonyl-2-nitrobenzene 
• 2469-99-0 Cyanoaceton 
• 453-72-5 1-fluoro-4-methanesulfonyl-2-nitrobenzene 
• 107-91-5 cyanoacetic acid amide 
• 104206-82-8 mesotrione 
• 788133-24-4 vanadium(V) oxide 
• 3185-99-7 Methyl p-tolyl sulfone 
• 54090-40-3 4-chlorosulfonyl-2-nitro-benzoic acid 

Downstream Products

• 393085-45-5 2-amino-4-(methylsulfonyl)benzoic acid 
• 110964-80-2 4-methylsulphonyl-2-nitrobenzoyl chloride 
• 226944-49-6 3-(4'-methylsulfonyl-2'-nitro-benzoyloxy)-2-cyclohexene-1-one 
• 415955-68-9 4-nitrophenyl 2-nitro-4-(methylsulfonyl)benzoate 
• 887243-81-4 1,1-dimethylethyl (2S)-cyclohexyl-({[4-(methylsulfonyl)-2-nitrophenyl]carbonyl}amino)ethanoate 
• 2976-32-1 1-methanesulfonyl-3-nitro-benzene 
• 104206-82-8 mesotrione 
• 62606-16-0 1-iodo-3-(methylsulfonyl)-5-nitrobenzene 
• 62606-15-9 1-bromo-3-(methylsulfonyl)-5-nitrobenzene 

Relevant articles and documents

Synthesis of 2-Nitro-4-methylsulfonylbenzoic Acid

2-Nitro-4-methylsulfonylbenzoic acid was synthesized by the oxidation of 2-nitro-4-methylsulfonyl toluene with hydrogen peroxide in the presence of CuO/Al2O3, which was first used in strong acid system. Furthermore, the process of the reaction was thoroughly investigated by varying reactant molar ratio, reaction temperature and the amount of catalyst to obtain the optimum process. Meanwhile, unreacted 2-nitro-4-methylsulfonyl toluene can be recycled after simple treatment. The yield can reach 78.3 %. The method demonstrated the following advantages. Firstly, the oxidant dosage of sulfuric acid and hydrogen peroxide will be reduced greatly. Secondly, unreacted 2-nitro-4-methylsulfonyl toluene can be recycled. Thirdly, this process had good performance on safety. It will be a high-efficiency, energy-saving and environment-friendly technology to produce 2-nitro-4-methylsulfonylbenzoic acid.

Synthetic method for oxidizing 2 - nitro -4 - methylsulfonyl toluene with oxygen to generate 2 - nitro -4 - methylsulfonylbenzoic acid

The invention relates to the field of fine chemical synthesis, in particular to a method for synthesizing 2 - nitro -4 - methylsulfonyl benzoic acid by oxidizing 2 - nitro -4 - methylsulfonyl toluene with oxygen. In the microchannel reactor, the catalyst is filled, oxygen is introduced, and 2 - nitro -4 - methylsulfonyltoluene is slowly introduced into the alkaline solution, wherein the oxygen is charged into the pressure maintaining 0.2 - 10 mpa, the reaction temperature is controlled to 130 - 200 °C. according to the obtained product content, and high conversion rate can be obtained. High selectivity, high content of continuous products.

Preparation method of 2-nitro-4-methylsulfonylbenzoic acid

The invention relates to a preparation method of 2-nitro-4-methylsulfonylbenzoic acid. Based on a nitric acid oxidation scheme, p-methylsulfonyltoluene is dissolved into a chloroalkane solvent, nitricacid is dropwise added into sulfuric acid with the mass fraction of 80-90wt%, a chloroalkane solution of p-methylsulfonyltoluene and a mixed acid solution are simultaneously and continuously added into a reaction system for a nitration reaction, the sulfuric acid is repeatedly used after the nitration reaction material liquid is treated, the sulfuric acid can be used both in the nitration reaction and the oxidation reaction, the sulfuric acid in the oxidation reaction can be repeatedly used, the total molar yield of the 2-nitro-4-methylsulfonylbenzoic acid can achieve more than 90%, and the content is more than 99%. By means of the method, the amount of waste acid in production of 2-nitro-4-methylsulfonylbenzoic acid can be reduced by 90% or above, the use amount of vanadium pentoxide isreduced by 90% or above, three wastes are greatly reduced, the process is safe and environmentally friendly, the amount of the three wastes is small, and the method is suitable for industrial large-scale production.

2 - Nitro -4 --methylsulfonyl benzoic acid (by machine translation)

The invention discloses a 2 - nitro - 4 - P-methylsulfonyl-benzoic acid synthesis method, using 3 - nitrophthalic acid as the substrate of reaction, willimson sulfonated, sulfinyl acidification, [...] and [...]-step chemical reaction, to obtain the 2 - nitro - 4 - P-methylsulfonyl-benzoic acid. The invention can avoid the use of large amount of sulfuric acid, nitric acid, to avoid high-risk oxidation reaction. The invention has the low cost of raw materials, the conversion is high, high production efficiency, pollution is small, and each step of mild reaction conditions, the reaction process is simple and easy to control and the like. The final product purity can be up to 99% or more, the four-step reaction and the total conversion rate can reach 90% or more, all organic solvent can be recycled, the new method is in line with the direction of the green chemical development clean production process. (by machine translation)