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1956-06-5

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1956-06-5 Usage

Description

P-Nitrophenyl propionate, with the molecular formula C9H9NO4, is a yellow crystalline solid that exhibits a melting point of 63-65°C. It is a chemical compound widely recognized for its role in biochemical research, particularly in the assessment of esterase enzymes and lipase activity. Its utility extends to the production of esters, which are employed across various industries, while also being noted as a potential sensitizing agent that may induce skin and eye irritation upon contact.

Uses

Used in Biochemical Research:
P-Nitrophenyl propionate is used as a chromogenic substrate for the assay of esterase enzymes, facilitating the detection and measurement of these enzymes' activity levels in biological samples.
Used in Lipase Activity Studies:
In the study of lipase activity, P-Nitrophenyl propionate serves as a substrate that, upon enzymatic action, releases p-nitrophenol, a compound that can be easily quantified, thus allowing for the assessment of lipase activity.
Used in the Production of Esters:
P-Nitrophenyl propionate is utilized in the synthesis of esters, which are compounds with diverse applications in industries such as pharmaceuticals, fragrances, and flavorings.
Used in Industrial Applications:
The esters produced using P-Nitrophenyl propionate are employed in various industrial applications, including the manufacturing of plastics, coatings, and other chemical products.
Used in Safety and Health Considerations:
As a potential sensitizing agent, P-Nitrophenyl propionate is used to inform safety protocols and material safety data sheets, ensuring that appropriate precautions are taken to prevent skin and eye irritation during its handling and use in research and industrial settings.

Check Digit Verification of cas no

The CAS Registry Mumber 1956-06-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,5 and 6 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1956-06:
(6*1)+(5*9)+(4*5)+(3*6)+(2*0)+(1*6)=95
95 % 10 = 5
So 1956-06-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H9NO4/c1-2-9(11)14-8-5-3-7(4-6-8)10(12)13/h3-6H,2H2,1H3

1956-06-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (4-nitrophenyl) propanoate

1.2 Other means of identification

Product number -
Other names 4-Nitrophenyl propionate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1956-06-5 SDS

1956-06-5Relevant articles and documents

Comparison of the kinetic specificity of subtilisin and thiolsubtilisin toward n-alkyl p-nitrophenyl esters.

Philipp,Tsai,Bender

, p. 3769 - 3773 (1979)

The p-nitrophenyl esters of straight-chain fatty acids were used as substrates of the enzyme subtilisin Novo (EC 3.4.4.16) and its chemically produced artificial enzyme thiolsubtilisin. Subtilisin and thiolsubtilisin pH--activity profiles were determined, and kinetic effects of the active site O-S substitution were observed. Among the substrates tested, both enzymes show highest specificity with p-nitrophenyl butyrate. It was also found that subtilisin is more sensitive to changes in substrate chain length than is thiolsubtilisin. Second-order acylation rate constants (k2/Ks) are remarkably similar for both enzymes. However, thiolsubtilisin deacylation rate constants and Km values are lower than analogous subtilisin constants. While thiolsubtilisin deacylation rate constants give a pH profile identical with that of subtilisin, the pH profile of thiolsubtilisin acylation rate constants shows an active site pK value lowered from the subtilisin pK of 7.15 and exhibits an inflection point at pH 8.45, which is absent in subtilisin.

Carboxylic Acid Deoxyfluorination and One-Pot Amide Bond Formation Using Pentafluoropyridine (PFP)

Brittain, William D. G.,Cobb, Steven L.

supporting information, p. 5793 - 5798 (2021/08/01)

This work describes the application of pentafluoropyridine (PFP), a cheap commercially available reagent, in the deoxyfluorination of carboxylic acids to acyl fluorides. The acyl fluorides can be formed from a range of acids under mild conditions. We also demonstrate that PFP can be utilized in a one-pot amide bond formation via in situ generation of acyl fluorides. This one-pot deoxyfluorination amide bond-forming reaction gives ready access to amides in yields of ≤94%.

Organocatalytic activation of alkylacetic esters as enolate precursors to react with α,β-unsaturated imines

Hao, Lin,Chen, Shaojin,Xu, Jianfeng,Tiwari, Bhoopendra,Fu, Zhenqian,Li, Tong,Lim, Jieyan,Chi, Yonggui Robin

supporting information, p. 4956 - 4959 (2013/10/22)

Asymmetric functionalization of alkylacetic esters and their derivatives is traditionally achieved via preformed enolates with chiral auxiliaries. Catalytic versions of such transformations are attractive but challenging. A direct catalytic activation of simple alkylacetic esters via N-heterocyclic carbene organocatalysts to generate chiral enolate intermediates for highly enantioselective reactions is reported.

Palladium/NHC-catalyzed tandem benzylic oxidation/oxidative esterification of benzylic alcohols with phenols

Luo, Fang,Pan, Changduo,Cheng, Jiang,Chen, Fan

supporting information; experimental part, p. 5878 - 5882 (2011/09/12)

A palladium/NHC-catalyzed tandem benzylic oxidation/oxidative esterification of benzylic alcohols with phenols to access aryl benzoate derivatives is described. The procedure tolerates a series of functional groups, such as methoxy, nitro, cyano, chloro, fluoro and bromo groups. Thus, it represents a practically alternative method to access aryl benzoate derivatives.

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