1032-84-4

Upstream product

• 22129-40-4 2'-hydroxy-4-methoxy-5'-methylchalcone dibromide 
• 27770-80-5 2-(4-methoxyphenyl)-6-methylchroman-4-one 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 6971-17-1 3-hydroxy-2-(4-methoxy-phenyl)-6-methyl-chromen-4-one 
• 5529-98-6 (+/-)-3t-hydroxy-2r-(4-methoxy-phenyl)-6-methyl-chroman-4-one 
• 94207-75-7 (2RS,3RS)-2-bromo-1-(3-bromo-2-hydroxy-5-methyl-phenyl)-3-hydroxy-3-(4-methoxy-phenyl)-propan-1-one 
• 4037-71-2 (2-hydroxy-5-methyl-phenyl)-[3-(4-methoxy-phenyl)-oxiranyl]-methanone 
• 90834-21-2 4-(4-methoxy-trans-styryl)-6-methyl-coumarin 
• 29976-77-0 6-methyl-4'-methoxyflavone 
• 27770-80-5 2-(4-methoxyphenyl)-6-methylchroman-4-one 
• 29976-88-3 3-(2-hydroxy-5-methylphenyl)-5-(4-methoxyphenyl)-Δ²-isoxazoline 
• 65840-96-2 5-Anisyl-3-(2-hydroxy-5-methylphenyl)-Δ²-pyrazoline 
• 37689-59-1 2-[5-(4-methoxy-phenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-4-methyl-phenol 
• 93259-57-5 8-bromo-3-hydroxy-2-(4-methoxy-phenyl)-6-methyl-chromen-4-one 
• 109556-83-4 3-acetoxy-2-(4-methoxy-phenyl)-6-methyl-chromen-4-one 

Relevant academic research and scientific papers

Specific Photoreactions of Flavanones Typical of n,?* and ?,?* Characters in Lowest Triplet States

On irradiation with u.v. light, flavanones undergo photochemical opening of the dihydropyranone ring (φ2 3 2, φ3, and γ with substituents are explicable in terms of relative contributions of n,?* and ?,?* character in lowest triplet states.

Synthesis and PPAR-γ ligand-binding activity of the new series of 2′-hydroxychalcone and thiazolidinedione derivatives

Fifteen chalcones and three thiazolidinedione (TZD) chalcones were prepared to evaluate their peroxisome proliferator-activated receptor-γ (PPAR-γ) ligand-binding activities. Among the three TZDs, one compound possessed PPAR-γ transactivation potential, while the others showed antagonistic activity against PPAR-γ transactivation. Among the chalcones, compound 5 was the most potent, and structure-activity relationship studies indicated that a methoxyl group in position C-4 and hydroxyl group in position C-4′ or 5′ in chalcone plays a key role in determining the potency of PPAR-γ activation.

Synthesis, in vitro antigiardial activity, SAR analysis and docking study of substituted chalcones

A series of 15 chalcones-bearing substituents at positions 2, 4, and 5 of rings A and B were synthesized using microwave-assisted Claissen–Smichdt condensation and evaluated for their activity against Giardia lamblia and Green monkey kidney cells. Five co

Discovery of 2′-hydroxychalcones as autophagy inducer in A549 lung cancer cells

A series of 2′-hydroxychalcone derivatives was synthesized and the effects of all the compounds on growth of A549 lung cancer cell were investigated. The results showed that all compounds had inhibitory effects on the growth of A549 lung cancer cells and compound 2-7 possessed the highest growth inhibitory effect and induced autophagy of A549 lung cancer cells.

Synthesis and biological activities of some flavones

Chalcones are synthesized by a base catalyzed Claisen Schmidt condensation reaction and then treated with dimethylsulphoxide in presence of iodine to get flavones. The synthesized compounds were evaluated for their antibacterial activity against Escherichia coilt P. aeruginosa, S. epidermidis and B. subtilis. All the flavones showed moderate to good activity. The structures of these compounds were confirmed by IR, UV, 1H NMR, Mass and elemental analysis.

A Novel Oxidative Cyclization of 2'-Hydroxychalcones to 4,5-Dialkoxyaurones by Thallium(III) Nitrate

Scope and mechanism studies are reported on a novel oxidative transformation of certain 2'-hydroxy-5'-methoxychalcones to aurones by thallium(II) nitrate (TTN) in alcoholic solvents.A key feature of the reaction is the incorporation of a solvent-derived alkoxy group at C-4 of the aurone.The thermodynamically more stable Z isomers of the aurones are obtained in all cases.Aurones are formed regardless of whether electron donating or electron attracting groups are present at the para position of the B ring of the starting chalcone.

Reaction of 2'-Hydroxychalcone Dibromides with Me2SO

2'-Hydroxychalcone dibromides on treatment with Me2SO gave 2'-hydroxychalcone, 2'-hydroxy-3'- or 2'-hydroxy-5'-bromochalcone, flavone, monobrominated flavone, 6,8-dibromoflavone, 3-bromoflavone, and 3-, 6-, or 8-dibromoflavone.

A Convenient Synthesis of 4-Styrylcoumarins

The title-compounds (IIa-m) have been prepared by condensing 2'-hydroxychalcones (Ia-m) with the easily accessible Wittig reagent Ph3P=CHCOOEt.