10327-08-9Relevant articles and documents
Catalytic Cracking of Lactide and Poly(Lactic Acid) to Acrylic Acid at Low Temperatures
Terrade, Frédéric G.,van Krieken, Jan,Verkuijl, Bastiaan J. V.,Bouwman, Elisabeth
, p. 1904 - 1908 (2017)
Despite being a simple dehydration reaction, the industrially relevant conversion of lactic acid to acrylic acid is particularly challenging. For the first time, the catalytic cracking of lactide and poly(lactic acid) to acrylic acid under mild conditions is reported with up to 58 % yield. This transformation is catalyzed by strong acids in the presence of bromide or chloride salts and proceeds through simple SN2 and elimination reactions.
Specific esterase activity of subtilisin toward esters of α-haloacids
Pugniere,Juan, C. San,Previero
, p. 4883 - 4886 (1990)
Esters of α-haloacids are specific substrates for subtilisin which catalyses their hydrolysis in aqueous media. The same esters undergo transesterifications in organic solvents in the presence of subtilisin immobilized on an alumina-phosphate complex.
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Cullis,Hashami
, p. 3080 (1957)
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Zwitterionic Hydrobromic Acid Carriers for the Synthesis of 2-Bromopropionic Acid from Lactide
Kehrer, Matthias,Mehler, Julian,Taccardi, Nicola,Nagengast, Jens,Kadar, Julian,Collias, Dimitris,Dziezok, Peter,Wasserscheid, Peter,Albert, Jakob
, p. 1063 - 1072 (2018)
A convenient and highly efficient way of synthesizing 2-bromopropionic acid (2-BrPA) from lactide is presented. The procedure uses ionic liquids obtained from the addition of HBr to ammonium-based zwitterions as the solvent and bromination agent. The buffered HBr acidity, high polarity, and charge stabilizing character of the ionic liquid (IL) enable the synthesis of 2-BrPA with excellent selectivity. The best results are obtained with an imidazolium-based IL, that is, 1-(4-butanesulfonic acid)-3-methylimidazolium bromide ([MIMBS]Br). The HBr loading and water content of the IL are crucial parameters for the bromination reaction. The formed 2-BrPA product can be selectively isolated by extraction from the IL, and the unconverted substrate remains in the [MIMBS]Br IL for the next run. Successful recycling of the IL over four cycles is demonstrated.
Enantioselective Construction of Axially Chiral Azepine-Containing P,N-Ligands from l -Alanine
Zhang, Jinlong,Gao, Zeng,Qian, Jinlong,Yang, Huameng,He, Maosheng,Jiang, Gaoxi
supporting information, p. 7814 - 7818 (2021/10/20)
A family of axially chiral azepine-containing seven-membered cyclic P,N-ligands (named Indole-azepinap) have been prepared by using l-alanine as an original chirality source. The direct chromatographic separation of two diastereomeric phosphine oxides on silica gel enabled these ligands to be easy available, allowing further structural and electronic modifications. Preliminary application of these Indole-azepinaps has been demonstrated in a Pd-catalyzed asymmetric allylic alkylation with high yields and moderate enantioselectivities.
TRICYCLIC COMPOUNDS HAVING SULFINYL AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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Paragraph 0069, (2020/01/02)
It is intended to provide a compound that exhibits a wide antibacterial spectrum against various bacteria including gram-negative bacteria, and a pharmaceutical composition having an antibacterial activity against carbapenem-resistant bacteria.