108583-48-8

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 2408-36-8 lithium cyanide 
• 1896-62-4 (E)-benzalacetone 
• 7677-24-9 trimethylsilyl cyanide 
• 104192-56-5 (Z)-4-Phenyl-2-trimethylsilanyloxy-but-2-enenitrile 
• 74-88-4 methyl iodide 
• 143-33-9 sodium cyanide 
• 14371-10-9 (E)-3-phenylpropenal 
• 70532-73-9 (Z)-4-Phenyl-2-(trimethylsilyloxy)-2-butennitril 
• 100573-50-0 (E)-4-phenyl-2-(trimethylsiloxy)but-3-enenitrile 
• 83575-64-8 C₁₃H₁₆LiNOSi 

Downstream Products

• 122-57-6 1-Phenylbut-1-en-3-one 

Relevant academic research and scientific papers

Cyanosilylation of ketones catalyzed by quaternary ammonium salt and N-oxide

Dibenzyldimethyl ammonium bromide and triethanolamine N-oxide catalyze the formation of cyanohydrin trimethylsilyl ethers of ketones in 80-99% yield.

Construction of tetrasubstituted carbon by an organocatalyst: Cyanation reaction of ketones and ketimines catalyzed by a nucleophilic N-heterocyclic carbene

A method for cyanation reaction of ketones and ketimines having lower reactivity than aldehydes and aldimines with TMSCN in the presence of N-heterocyclic carbene prepared from 1,3-bis(2,4,6-trimethylphenyl)imidazolium chloride and potassium tert-butoxide

Efficient and Regioselective Cyanosilylation of Cyclohex-2-enone and Other Unsaturated Ketones over Solid Acid and Base Catalyst

Cyanotrimethylsilane reacts with α,β-unsaturated ketones to afford 1,4- and 1,2-adducts regioselectively in the presence of strongly acidic montmorillonite and strongly basic CaO or MgO, respectively.

Iodine as novel reagent for the 1,2-addition of trimethylsilyl cyanide to ketones including α,β-unsaturated ketones

Molecular iodine is found to catalyze efficiently the addition of trimethylsilyl cyanide to a range of simple and functionalized ketones under very mild and convenient conditions to afford the corresponding cyanohydrin trimethylsilyl ethers in excellent y

Catalytic cyanosilylation of ketones using organic catalyst 1,1,3,3-tetramethylguanidine

1,1,3,3-Tetramethylguanidine acts as a highly effective catalyst for cyanosilylation of various ketones and aldehydes to the corresponding cyanohydrin trimethylsilyl ethers in up to 99% yield. The reaction proceeds smoothly with 0.1 mol % catalyst loading

Mild and efficient trimethylsilylcyanation of ketones catalysed by PNP chloride

Mild & green: The commercially and readily available PNPCl behaves as a very effective catalyst for the synthesis of various trimethylsilyl cyanohydrins from a wide range of aliphatic, cyclic, α,β-unsaturated and aromatic ketones. The method proceeds at r

Phenolic N-oxide as a highly efficient organocatalyst for cyanosilylation of ketones

The use of an inexpensive, easy to handle and readily available chemical, 5 mol% phenolic N-oxide, alone as a catalyst for cyanosilylation of ketones gave the corresponding products in 78-99% yield with reaction times of 0.5-16 hours.

Synthesis, characterization, and reactivity of lanthanide amides incorporating neutral pyrrole ligand. Isolation and characterization of active catalyst for cyanosilylation of ketones

A series of lanthanide amido complexes incorporating a neutral pyrrole ligand were synthesized and characterized, and their catalytic activities were studied. Treatment of [(Me3Si)2N]3Ln(μ-Cl)Li(THF)3 with 1 equ

Catalytic cyanosilylation of ketones with simple phosphonium salt

In the presence of 1-5 mol % of benzyltriphenylphosphonium chloride, a wide variety of unconjugated and conjugated, acyclic and cyclic ketones were transformed to their corresponding cyanohydrin silyl ethers in excellent yields.

A convenient catalytic procedure for the addition of trimethylsilyl cyanide to functionalised ketones, mediated by InBr3 - Insight into the reaction mechanism

This paper describes a useful and practical methodology for the addition of trimethylsilyl cyanide (TMSCN) to a large variety of functionalised and unfunctionalised ketones in the presence of catalytic amounts of anhydrous InBr3. The optimum pr