118-78-5Relevant articles and documents
Rate of Decomposition of Murexide in Mixed Solvents: An Indicator for Proton Activity
Barrabass, Susanne,Stickdorn, Katrin,Knoche, Wilhelm
, p. 637 - 642 (1995)
The rate of decomposition of murexide depends strongly on the proton concentration.The observed rate constant correlates well with the relative permittivity of the solvent.This correlation is established by measurements in binary mixtures of water-dioxane and water-ethanol between 20 and 40 deg C and may be applied to the estimation of the proton concentration in the aqueous domains of microemulsions.
Oxidation of Uric Acid. 4. Synthesis, Structure, and Diabetogenic Action of 5-Imino-2,4,6(1H,3H,5H)-pyrimidinetrione Salts and Their Alloxan-Like Covalent Adducts
Poje, Mirko,Rocic, Boris,Sikirica, Milan,Vickovic, Ivan,Bruvo, Milenko
, p. 861 - 864 (2007/10/02)
Three synthetic routes to salts of 5-amino-5-hydroxy-2,4,6(1H,3H,5H)-pyrimidinetrione (10) are described.The key reactions involved acid-catalyzed cleavage of 5-amino-5-ureido-2,4,6(1H,3H,5H)-pyrimidinetrione (7), conversion of uramil (8) to dehydrouramil (9) and subsequent hydration, and the condensation of alloxan (5) with ammonium salts.The carbinol ammonium salt structure 10a was unambiguously established by X-ray crystallography.New alloxan-like compounds 7, 9, and 10 were evaluated for diabetogenic activity in rats.Compound 7 was inactive, whereas compounds 9 and 10 showed the highest activity comparable to that of streptozotocin (12).