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1199-00-4

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1199-00-4 Usage

Description

3-Methyl-5-phenyl-1,2,4-oxadiazole is a heterocyclic chemical compound with the molecular formula C9H8N2O. It features a five-membered ring structure containing both nitrogen and oxygen atoms. This versatile compound is known for its potential biological activities, such as anti-inflammatory, antioxidant, and antitumor properties, and is utilized in various industries for the synthesis of pharmaceuticals, agrochemicals, and materials.

Uses

Used in Pharmaceutical Industry:
3-Methyl-5-phenyl-1,2,4-oxadiazole is used as a key intermediate in the synthesis of various pharmaceuticals for its potential biological activities. Its anti-inflammatory, antioxidant, and antitumor properties make it a valuable component in the development of new drugs targeting a range of health conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Methyl-5-phenyl-1,2,4-oxadiazole serves as a building block in the creation of agrochemicals. Its incorporation into these products can enhance their effectiveness in protecting crops and improving agricultural yields.
Used in Materials Science:
3-Methyl-5-phenyl-1,2,4-oxadiazole is utilized in the development of advanced materials due to its unique chemical properties. It contributes to the improvement of material characteristics such as stability, reactivity, and other desirable traits in various applications.
Used in Organic Electronics:
As a component in organic electronic materials, 3-Methyl-5-phenyl-1,2,4-oxadiazole plays a role in enhancing the performance of devices such as organic light-emitting diodes (OLEDs) and organic solar cells, thanks to its electronic properties.
Used as a Fluorescence Probe in Biomedical Applications:
3-Methyl-5-phenyl-1,2,4-oxadiazole is employed as a fluorescence probe in biomedical research. Its optical properties allow for its use in imaging and sensing applications, contributing to advancements in the study and diagnosis of diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 1199-00-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,9 and 9 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1199-00:
(6*1)+(5*1)+(4*9)+(3*9)+(2*0)+(1*0)=74
74 % 10 = 4
So 1199-00-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H8N2O/c1-7-10-9(12-11-7)8-5-3-2-4-6-8/h2-6H,1H3

1199-00-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Methyl-5-phenyl-1,2,4-oxadiazole

1.2 Other means of identification

Product number -
Other names 3-Methyl-5-phenyl-1,2,4-oxdiazol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1199-00-4 SDS

1199-00-4Relevant articles and documents

Beyond direct Nrf2 activation; reinvestigating 1,2,4-oxadiazole scaffold as a master key unlocking the antioxidant cellular machinery for cancer therapy

Ayoup, Mohammed Salah,Abu-Serie, Marwa M.,Abdel-Hamid, Hamida,Teleb, Mohamed

, (2021/04/27)

Harnessing the antioxidant cellular machinery has sparked considerable interest as an efficient anticancer strategy. Activating Nrf2, the master switch of the cellular redox system, suppresses ROS, alleviates oxidative stress, and halts cancer progression

Construction of 3,5-substituted 1,2,4-oxadiazole rings triggered by tetrabutylammonium hydroxide: A highly efficient and fluoride-free ring closure reaction of O-acylamidoximes

Otaka, Hiromichi,Ikeda, Junya,Tanaka, Daisuke,Tobe, Masanori

, p. 979 - 981 (2014/02/14)

Tetrabutylammonium hydroxide (TBAH) is an efficient and mild alternative to tetrabutylammonium fluoride (TBAF) for base catalyzed cyclizations of 1,2,4-oxadiazoles from O-acylamidoximes. For most 3,5-substituted 1,2,4-oxadiazoles the reactions were dramatically accelerated by addition of 0.1 equiv of TBAH at room temperature. This method was also more generally applicable allowing for a wider range of substrates. Additionally, due to the absence of fluoride, TBAH will not result in corrosion of reactor vessels and therefore is better suited for large-scale synthesis.

A metal-free tandem approach to prepare structurally diverse N-heterocycles: Synthesis of 1,2,4-oxadiazoles and pyrimidinones

Gupta, Puneet K.,Hussain, Mohd. Kamil,Asad, Mohd.,Kant, Ruchir,Mahar, Rohit,Shukla, Sanjeev K.,Hajela, Kanchan

, p. 3062 - 3070 (2014/07/07)

A metal-free one-pot approach to the diversity oriented synthesis of N-heterocycles, 1,2,4-oxadiazoles and 2,6 disubstituted pyrimidin-4-ones is described via carboxamidation of amidines with aryl carboxylic acids and aryl propargylic acids. The reactions occur at room temperature forming N-acylamidines which undergo tandem nucleophilic addition-deamination- intramolecular cyclisation to give the corresponding heterocyclic compounds in good to excellent yields. This one pot approach has led to the successful synthesis of the drug lead molecule, ataluren, 3-(5-(2-fluorophenyl)-1,2,4- oxadiazol-3-yl) benzoic acid in two steps. the Partner Organisations 2014.

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