122-06-5

Usage

Uses

Used in Pharmaceutical Industry:
Stilbamidine is used as an antiprotozoal medication for the treatment of leishmaniasis, a parasitic infection, due to its ability to inhibit the growth and replication of the Leishmania parasites.
Used in Treatment of Severe Leishmaniasis:
Stilbamidine is used as a therapeutic agent for severe cases of leishmaniasis that do not respond to other available medications, providing an important treatment option in certain circumstances. Its administration is typically through injection into the muscles or veins, and its use is closely monitored by healthcare professionals to manage potential side effects such as kidney toxicity.

Upstream product

• 3424-93-9 4-methoxyphenylacetamide 
• 925-90-6 ethylmagnesium bromide 
• 7448-86-4 1-(4-methoxyphenyl)prop-2-en-1-one 
• 7465-86-3 4-methoxy-N,N-diethylbenzamide 
• 1201-60-1 1-(1,2-dibromopropyl)-4-methoxybenzene 
• 127193-12-8 2-bromo-1-methoxy-1-(4-methoxyphenyl)-propane 
• 124-41-4 sodium methylate 
• 857591-12-9 1-(1-ethoxy-2-bromo-propyl)-4-methoxy-benzene 
• 141-52-6 sodium ethanolate 
• 79-03-8 propionyl chloride 
• 100-66-3 methoxybenzene 
• 2125-49-7 3-dimethylamino-1-(4-methoxy-phenyl)-propan-1-one; hydrochloride 
• 802294-64-0 propionic acid 
• 123-62-6 propionic acid anhydride 

Downstream Products

• 133005-88-6 cis-stilbene-4,4’-dicarboxylic acid 

Relevant academic research and scientific papers

V2O5@TiO2 Catalyzed Green and Selective Oxidation of Alcohols, Alkylbenzenes and Styrenes to Carbonyls

The versatile application of different functional groups such as alcohols (1° and 2°), alkyl arenes, and (aryl)olefins to construct carbon-oxygen bond via oxidation is an area of intense research. Here, we report a reusable heterogeneous V2O5@TiO2 catalyzed selective oxidation of various functionalities utilizing different mild and eco-compatible oxidants under greener reaction conditions. The method was successfully applied for the alcohol oxidation, oxidative scission of styrenes, and benzylic C?H oxidation to their corresponding aldehydes and ketones. The utilization of mild and eco-friendly oxidizing reagents such as K2S2O8, H2O2 (30 % aq.), TBHP (70 % aq.), broad substrate scope, gram-scale synthesis, and catalyst recyclability are notable features of the developed protocol.

Development of Trifluoromethanesulfonic Acid-Immobilized Nitrogen-Doped Carbon-Incarcerated Niobia Nanoparticle Catalysts for Friedel-Crafts Acylation

Heterogeneous trifluoromethanesulfonic acid-immobilized nitrogen-doped carbon-incarcerated niobia nanoparticle catalysts (NCI-Nb-TfOH) that show excellent catalytic performance with low niobium loading (1 mol %) in Friedel-Crafts acylation have been developed. These catalysts exhibit higher activity and higher tolerance to catalytic poisons compared with the previously reported TfOH-treated NCI-Ti catalysts, leading to a broader substrate scope. The catalysts were characterized via spectroscopic and microscopic studies.

Well-Dispersed Trifluoromethanesulfonic Acid-Treated Metal Oxide Nanoparticles Immobilized on Nitrogen-Doped Carbon as Catalysts for Friedel–Crafts Acylation

Although strong acid-treated metal oxides are useful heterogeneous superacid catalysts for various organic transformations, they usually have a limited density of acidic sites due to their low surface areas. Herein, heterogeneous trifluoromethanesulfonic acid immobilized nitrogen-doped carbon-incarcerated titanium nanoparticle (NP) catalysts have been developed that are composed of well-dispersed, small Ti NPs (ca 7 nm) that are otherwise difficult to achieve using acid-treated metal oxides. The catalysts showed high activity for Friedel–Crafts acylation with low titanium loading (2 mol%, 1 mg of metal for 1 mmol of substrate). A range of microscopic, spectroscopic and physicochemical studies revealed that the nitrogen-doped carbon immobilized the trifluoromethanesulfonic acid and that the addition of metals further changed the nature of the acidic species and enhanced catalytic activity.

Photoredox/nickel-catalyzed hydroacylation of ethylene with aromatic acids

We report a general, practical and scalable hydroacylation reaction of ethylene with aromatic carboxylic acids with the synergistic combination of nickel and photoredox catalysis. Under ambient temperature and pressure, feedstock chemicals such as ethylene can be converted into high-value-added aromatic ketones in moderate to good yields (up to 92%) with reaction time of 2-6 hours.

Non-plasmonic Ni nanoparticles catalyzed visible light selective hydrogenolysis of aryl ethers in lignin under mild conditions

Light-driven catalysis on catalytically versatile group VIII metals, which has been widely used in thermal catalysis, holds great potential in solar-to-chemical conversion. We report a novel photocatalysis process for the selective hydrogenolysis of aryl ethers in lignin on a heterogeneous catalyst of non-precious Ni nanoparticles supported on ZrO2. Three aryl ether bonds in lignin were successfully cleaved under mild conditions with excellent conversion and good to excellent selectivity under visible light irradiation. We also used solar irradiation to demonstrate a significant reduction in the total energy consumption. The light irradiation excited interband transitions in Ni nanoparticles and the resultant energetic electrons enhanced the activity of reductive cleavage of the aryl ethers. Its application potential was illustrated by the depolymerization of dealkaline lignin to give a total monomer yield of 9.84 wt% with vanillin, guaiacol, and apocynin as the three major products.

Copper-Catalyzed Methoxylation of Aryl Bromides with 9-BBN-OMe

A Cu-catalyzed cross-coupling reaction between aryl bromides and 9-BBN-OMe to provide aryl methyl ethers under mild conditions is reported. The oxalamide ligand BHMPO plays a key role in the transformation. Various functional groups on bromobenzenes are well tolerated, providing the desired anisole products in moderate to high yields.

Method for preparing ketone compound from olefin

The invention belongs to the technical field of organic chemical synthesis, and discloses a method for preparing a ketone compound from olefin by using an iron catalyst. According to the invention, the ligand and the iron salt form an iron catalyst in the on-site reaction, the raw materials in the formula are easy to obtain, and the synthesis is simple. By using the catalyst, olefin can be efficiently converted into ketone compounds, and compared with a palladium catalyst, the price is very low, and the catalyst is suitable for industrial application.

Catalytic Aerobic Oxidation of Alkenes with Ferric Boroperoxo Porphyrin Complex; Reduction of Oxygen by Iron Porphyrin

We herein describe the development of a mild and selective catalytic aerobic oxidation process of olefins. This catalytic aerobic oxidation reaction was designed based on experimental and spectroscopic evidence assessing the reduction of atmospheric oxygen using a ferric porphyrin complex and pinacolborane to form a ferric boroperoxo porphyrin complex as an oxidizing species. The ferric boroperoxo porphyrin complex can be utilized as an in-situ generated intermediate in the catalytic aerobic oxidation of alkenes under ambient conditions to form oxidation products that differ from those obtained using previously reported ferric porphyrin catalysis. Moreover, the mild reaction conditions allow chemoselective oxidation to be achieved.

Visible-light-promoted α-methoxymethylation and aminomethylation of ketones with methanol as the C1 source

Visible-light-promoted α-methoxymethylation and aminomethylation of ketones using methanol as a sustainable C1 source have been developed. With rose bengal as the photosensitizer and air as the green oxidant, the methoxymethylation reactions proceeded smoothly under visible light irradiation at ambient temperature. Additionally, a one-pot one-step α-aminomethylation of ketones was achieved by adding N-nucleophiles. Preliminary mechanism studies suggest that the reaction mainly proceedsviaa radical pathway.

Rhenium(I)-Catalyzed C-Methylation of Ketones, Indoles, and Arylacetonitriles Using Methanol

A ReCl(CO)5/MeC(CH2PPh2)3 (L2) system was developed for the C-methylation reactions utilizing methanol and base, following the borrowing hydrogen strategy. Diverse ketones, indoles, and arylacetonitriles underwent mono-and dimethylation selectively up to 99% yield. Remarkably, tandem multiple methylations were also achieved by employing this catalytic system.