124506-31-6

Basic information

• Product Name: (R)-Tetrahydrofuran-3-ylm...
• Synonyms: (R)-Tetrahydrofuran-3-ylm...;(3R)-oxolan-3-ylMethanol;(R)-Tetrahydrofuran-3-ylMethanol;(3R)-tetrahydro-3-Furanmethanol;[(3R)-Tetrahydrofuran-3-yl]methanol
• CAS NO: 124506-31-6
• Molecular Formula: C₅H₁₀O₂
• Molecular Weight: 102.1317
• Mol File: 124506-31-6.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 198.6±0.0 °C(Predicted)
• Appearance: /
• Density: 1.038±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 14.81±0.10(Predicted)
• CAS DataBase Reference: (R)-Tetrahydrofuran-3-ylm...(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-Tetrahydrofuran-3-ylm...(124506-31-6)
• EPA Substance Registry System: (R)-Tetrahydrofuran-3-ylm...(124506-31-6)

Safety Data

• Hazardous Substances Data: 124506-31-6(Hazardous Substances Data)

Usage

Description

(R)-Tetrahydrofuran-3-ylmethylamine, also known as (R)-THF-3-ylmethylamine, is a derivative of tetrahydrofuran, a well-known organic compound. It is a member of the tetrahydrofurans, which are heterocyclic compounds with a five-membered ring structure consisting of four carbon atoms and one oxygen atom. The structure and exact properties of this kind of chemical can vary depending on the additional groups attached to the base tetrahydrofuran molecule, although it generally retains a number of important chemical characteristics. Often, these kinds of compounds serve as intermediates in a variety of complex organic syntheses. Stereospecific variants like (R)-Tetrahydrofuran-3-ylmethylamine are an area of considerable research in organic chemistry due to their potential utility in synthesizing other compounds.

Uses

Used in Organic Synthesis:
(R)-Tetrahydrofuran-3-ylmethylamine is used as an intermediate in various complex organic syntheses for its potential utility in synthesizing other compounds. Its unique structure and properties make it a valuable component in the development of new organic molecules.
Used in Pharmaceutical Industry:
(R)-Tetrahydrofuran-3-ylmethylamine is used as a building block in the synthesis of pharmaceutical compounds, contributing to the development of new drugs and therapeutic agents. Its versatility in organic chemistry allows for the creation of diverse molecular structures with potential medicinal applications.
Used in Chemical Research:
(R)-Tetrahydrofuran-3-ylmethylamine is used as a research compound in the field of organic chemistry, where it aids in understanding the properties and reactions of tetrahydrofurans and their derivatives. This knowledge can be applied to the design and synthesis of new compounds with specific characteristics and applications.

Upstream product

• 63972-17-8 1,3-diethyl 2-(2-hydroxyethyl)propanedioate 
• 6482-32-2 2-(hydroxymethyl)butane-1,4-diol 
• 69595-02-4 tetrahydrofuran-3-carbonyl chloride 
• 89364-31-8 3-tetrahydrofuroic acid 
• 168395-26-4 (S)-tetrahydro-furan-3-carboxylic acid 
• 1050496-32-6 (S)-2-([(tetrahydro-3-furanylmethyl)oxy]carbonyl)benzoic acid 
• 1050496-18-8 (4R)-4-(phenylmethyl)-3-[(3S)-tetrahydro-3-furanylcarbonyl]-1,3-oxazolidin-2-one 
• 322639-11-2 (4S)-4-(phenylmethyl)-3-[(3S)-tetrahydro-3-furanylcarbonyl]-1,3-oxazolidin-2-one 
• 1708-29-8 2,5-dihydrofuran 
• 74-97-5 chlorobromomethane 
• 109-99-9 tetrahydrofuran 
• 67-56-1 methanol 
• 5472-38-8 diethyl 2-formylbutanedioate 
• 18132-98-4 α-hydroxymethyl-γ-butyrolactone 

Downstream Products

• 13423-15-9 3-methyltetrahydrofuran 
• 64190-48-3 dihydro-4-methyl-2(3H)-furanone 
• 1679-47-6 3-methyltetrahydro-2-furanone 
• 15833-63-3 (tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate 
• 1050496-28-0 2-([(tetrahydro-3-furanylmethyl)oxy]carbonyl)benzoic acid 
• 89181-22-6 3-(chloromethyl)tetrahydrofuran 
• 165253-31-6 (tetrahydro-3-furanyl)methylamine 
• 1194597-02-8 (3S)-tetrahydrofuran-3-ylmethyl 4-methylbenzenesulfonate 
• 726180-98-9 (R)-(tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate 
• 1453861-43-2 (R)-ethyl 2-(3-(4-((2',6'-dimethyl-4'-((tetrahydrofuran-3-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate 
• 1453861-44-3 (R)-2-(3-(4-((2',6'-dimethyl-4'-((tetrahydrofuran-3-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic acid 
• 1574394-76-5 4-((tetrahydrofuran-3-yl)methoxy)-3-(trifluoromethoxy)benzaldehyde 
• 1574394-65-2 2-amino-6-oxo-4-(4-(tetrahydrofuran-3-yl)methoxy-3-(trifluoromethoxy)phenyl)-1,6-dihydropyrimidine-5-carbonitrile 
• 1607822-72-9 3-((2-(trifluoromethoxy)phenoxy)methyl)tetrahydrofuran 

Relevant articles and documents

3-(5-METHOXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of formula (I') and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

Preparation method of tetrahydro-3-furanmethanol

The invention relates to the field of preparation of insecticides, in particular to a preparation method of tetrahydro-3-furanmethanol. The method comprises the steps as follows: 13.6 g of sodium ethoxide and 0.5 g of sodium iodide are dissolved in 120 mL of absolute ethyl alcohol, 32 g of diethyl malonate is dropwise added in an ice-water bath, the temperature is controlled at 20 DEG C or below,stirring is performed continuously for 1 h after addition, then 30.3 g of ethyl bromoacetate is slowly added, the temperature is increased to 50-60 DEG C after addition, stirring is performed for about 8 h, ethyl bromoacetate is detected to be used up through gas chromatography, a heating reaction is stopped, the system is cooled to the room temperature, 10 mL of a saturated ammonium chloride solution is added with stirring, the system is adjusted to be neutral or slightly acid, solvent ethyl alcohol is evaporated, residues are dissolved in 100 mL of water and 100 mL of ethyl acetate for extraction, solution separation is performed, an organic phase is separated, the solvent ethyl acetate is removed from the organic phase, reduced pressure distillation is performed through an oil pump, andthe first fraction point, namely, a triethyl 1,1,2-ethanetricarboxylate product, is collected. The process is simple, safety in actual production is guaranteed, and the product with higher yield is obtained.

Production technology for 3-hydroxymethyltetrahydrofuran

The invention discloses a production technology for 3-hydroxymethyltetrahydrofuran, and belongs to the field of pesticide intermediate synthetic processes. The production technology is capable of using 2-butene-1,4-diol as a starting raw material, and synthesizing the 3-hydroxymethyltetrahydrofuran through a three-step reaction of dehydration cyclization, hydroformylation and reduction. The production technology is moderate in reaction conditions, low in cost, less in three wastes, and suitable for the industrial production.