13064-83-0

Basic information

• Product Name: trans-4-Methylcyclohexanecarboxylic acid
• Synonyms: TRANS-4-METHYL HEXAHYDROBENZOIC ACID;TRANS-4-METHYLCYCLOHEXANECARBOXYLIC ACID;trans-4-Methyl-1-cyclohexanecarboxylic acid;4-methylcyclohexane-1-carboxylic acid;Cyclohexanecarboxylic acid, 4-methyl-, trans-;trans-4-Methylcycloh;trans-4-Methyl-1-cyclohexanecarboxylic acid, 98+%;trans-4-Methyl-l-cyclohexanecarboxylic acid
• CAS NO: 13064-83-0
• Molecular Formula: C₈H₁₄O₂
• Molecular Weight: 142.2
• EINECS: 235-959-6
• Product Categories: Biphenyl & Diphenyl ether;(intermediate of glimepiride);4-Alkylcyclohexanecarboxylic Acids (Building Blocks for Liquid Crystals);4-Substituted Cyclohexanecarboxylic Acids;Building Blocks for Liquid Crystals;Functional Materials;C8;Carbonyl Compounds;Carboxylic Acids;Building Blocks;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks
• Mol File: 13064-83-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 109-111 °C(lit.)
• Boiling Point: 245 °C
• Flash Point: 110.727 °C
• Appearance: /
• Density: 1.025 g/cm³
• Vapor Pressure: 0.008mmHg at 25°C
• Refractive Index: 1.467
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: pK1:4.89 (25°C)
• CAS DataBase Reference: trans-4-Methylcyclohexanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: trans-4-Methylcyclohexanecarboxylic acid(13064-83-0)
• EPA Substance Registry System: trans-4-Methylcyclohexanecarboxylic acid(13064-83-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 13064-83-0(Hazardous Substances Data)

Usage

Chemical Properties

White crystal

Uses

trans-4-Methyl-1-cyclohexanecarboxylic acid may be used in chemical synthesis.

InChI:InChI=1/C8H14O2/c1-6-2-4-7(5-3-6)8(9)10/h6-7H,2-5H2,1H3,(H,9,10)/t6-,7-

Upstream product

• 934-67-8 (cis)-4-methylcyclohexanecarboxylic acid 
• 99-94-5 p-Toluic acid 
• 201230-82-2 carbon monoxide 
• 82166-21-0 methyl cyclohexane 
• 64-19-7 acetic acid 
• 17264-54-9 sodium p-methylbenzoate 
• 7647-01-0 hydrogenchloride 
• 60940-94-5 cis-4-methyl-cyclohexane-carboxylic acid-⁽¹⁾-amide 
• 124-38-9 carbon dioxide 
• 931-68-0 1-chloro-4-methylcyclohexane 
• 51181-40-9 methyl 4-methyl-1-cyclohexanecarboxylate 
• 29886-34-8 4-methyl-1-cyclohexanecarboxylic acid methyl ester 
• 589-91-3 p-methylcyclohexanol 
• 1879-06-7 4-acetyl-1-methylcyclohexane 

Downstream Products

• 41692-50-6 trans-4-methyl-1-(ethoxycarbonyl)cyclohexane 
• 60940-94-5 (trans)-4-methylcyclohexane-1-carboxamide 
• 93007-36-4 trans-4-methyl-cyclohexane-carboxylic acid-⁽¹⁾-(4-bromo-phenacyl ester) 
• 3937-49-3 (trans-4-methylcyclohexyl)methanol 
• 55930-23-9 trans-4-methylcyclohexanecarbonyl chloride 
• 591-47-9 4-methylcyclohexene 
• 7731-29-5 trans-4-methylcyclohexan-1-ol 
• 589-92-4 1-methylcyclohexan-4-one 
• 942589-57-3 methyl 3-[[(trans-4-methylcyclohexyl)carbonyl](1-methylethyl)amino]-5-phenyl-2-thiophenecarboxylate 
• 859204-41-4 tert-butyl 4-[5-{isopropyl[(trans-4-methylcyclohexyl)carbonyl]amino}-4-(methoxycarbonyl)-2-thienyl]piperidine-1-carboxylate 
• 859204-10-7 methyl 2-{isopropyl[(trans-4-methylcyclohexyl)carbonyl]amino}thiophene-3-carboxylate 
• 58752-86-6 4-methylcyclohexanecarbonyl chloride 
• 125533-10-0 2-(4-methylcyclohexyl)-1-phenylethan-1-one 

Relevant articles and documents

Electrocatalytic hydrogenation of benzoic acids in a proton-exchange membrane reactor

The highly efficient chemoselective electrocatalytic hydrogenation of benzoic acids (BAs) to cyclohexanecarboxylic acids (CCAs) was carried out in a proton-exchange membrane reactor under mild conditions without hydrogenation of the carboxyl group. Among the investigated catalysts, the PtRu alloy catalyst was found to be the most suitable for achieving high current efficiencies for production of CCAs. An electrochemical spillover mechanism on the PtRu alloy catalyst was also proposed.

NOVEL COMPOUNDS

Novel rapamycin analogues and methods for their production with FKBP and/or MIP inhibitory activity with reduced mTOR inhibitory activity with therapeutic potential e.g. as bacterial virulence inhibitors.

Epimerization of 2- or 4- substituted cyclohexanecarboxylic acids

The present invention relates to a new method for obtaining a purity of about 93% to 100% of the trans form of 2- or 4-substituted cyclohexanecarboxylic acid or reactive derivatives thereof from the cis form or a mixture of the cis and trans forms by a single step, particularly, to a method for obtaining a purity of substantially 100% of the trans form of 4-substituted cyclohexanecarboxylic acid.