13114-92-6

Basic information

• Product Name: 1-(4-bromophenyl)-3-phenyl-urea
• Synonyms: 1-(4-bromophenyl)-3-phenyl-urea
• CAS NO: 13114-92-6
• Molecular Weight: 291.147
• Mol File: 13114-92-6.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 1-(4-bromophenyl)-3-phenyl-urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-bromophenyl)-3-phenyl-urea(13114-92-6)
• EPA Substance Registry System: 1-(4-bromophenyl)-3-phenyl-urea(13114-92-6)

Safety Data

• Hazardous Substances Data: 13114-92-6(Hazardous Substances Data)

Upstream product

• 14917-59-0 p-bromobenzoyl azide 
• 62-53-3 aniline 
• 586-78-7 para-nitrophenyl bromide 
• 313225-01-3 (1H-benzo[d][1,2,3]triazol-1-yl)(4-bromophenyl)methanone 
• 500-72-1 oxanilic acid 
• 106-40-1 4-bromo-aniline 
• 19226-36-9 3-phenyl-5H-1,4,2-dioxazol-5-one 
• 67-66-3 chloroform 
• 589-87-7 1,4-bromoiodobenzene 
• 103-71-9 phenyl isocyanate 
• 104-94-9 4-methoxy-aniline 
• 1073974-16-9 S-p-methoxyphenyl N-p-bromophenylthiocarbamate 
• 64-10-8 phenyl carbamate 
• 7664-93-9 sulfuric acid 

Downstream Products

• 1431632-30-2 C₁₆H₁₄N₄O 
• 1452815-81-4 1-deazapurine 1-(4-bromophenyl)-3-phenylurea 
• 819056-67-2 N-phenyl-N'-[4-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)phenyl]urea 
• 1219727-48-6 1-(4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-3-phenylurea 

Relevant articles and documents

Catalyst-free solventless synthesis of polysubstituted urea Method for preparing thioureas and chiral ureas and thiourea compounds

The invention discloses a method for synthesizing polysubstituted urea, thiourea and chiral urea and thiourea compounds without catalyst without solvent, and the method comprises A contact reaction of an amine compound with a structure shown B as shown first in a non-catalyst and a solventless condition to prepare a polysubstituted urea or thiourea compound with a structure as shown C. R1 And R2 Each independently selected from a hydrocarbyl or substituted hydrocarbyl group, R3 The method is selected from H, hydrocarbyl or substituted hydrocarbyl, X is S or o. The method solves the defect that a catalyst and/or a solvent need to be used in the synthesis of urea and thiourea compounds in the prior art.

Nitroarenes as versatile building blocks for the synthesis of unsymmetrical urea derivatives and N-Arylmethyl-2-substituted benzimidazoles

In this contribution, a fast and simple method for the synthesis of unsymmetrical urea derivatives and N-arylmethyl-2-substituted benzimidazoles was developed starting from nitroarenes. The reaction of nitroarenes and phenyl isocyanate or phenyl isothiocyanate in tin (II) chloride dihydrate/choline chloride eutectic mixture afforded the expected urea and thiourea derivatives, while the reaction of different aldehydes with o-nitroaniline or 4-methoxy-2-nitroaniline shows a markedly high preference for the obtention of N-arylmethyl-2-substituted benzimidazoles over the 2-substituted analogues. This method offers a straightforward alternative to obtain the target compounds in good to excellent yields with short reaction times employing an operationally simple experimental set-up. Graphic abstract: [Figure not available: see fulltext.] A series of unsymmetrical urea and thiourea derivatives together with 1,2-disubstituted benzimidazoles are easily obtained in good yields starting from nitroarenes employing the eutectic mixture tin (II) chloride dihydrate/choline chloride as reductive reaction media.

Direct conversion of carboxylic acids to various nitrogen-containing compounds in the one-pot exploiting curtius rearrangement

Herein we report, a single-pot multistep conversion of inactivated carboxylic acids to various N-containing compounds using a common synthetic methodology. The developed methodology rendered the use of carboxylic acids as a direct surrogate of primary amines, for the synthesis of primary ureas, secondary/tertiary ureas, O/S-carbamates, benzoyl ureas, amides, and N-formyls, exploiting the Curtius reaction. This approach has a potential to provide a diversified library of N-containing compounds, starting from a single carboxylic acid, based on the selection of the nucleophile.