131427-21-9

Basic information

• Product Name: 1-BENZYL-3-HYDROXYMETHYL-1H-INDAZOLE
• Synonyms: 1-BENZYL-3-HYDROXYMETHYL-1H-INDAZOLE;(1-Benzyl-1H-indazol-3-yl)Methanol;(1-benzylindazol-3-yl)methanol
• CAS NO: 131427-21-9
• Molecular Formula: C₁₅H₁₄N₂O
• Molecular Weight: 238.28
• Product Categories: Indoles and derivatives
• Mol File: 131427-21-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 450.624 °C at 760 mmHg
• Flash Point: 226.33 °C
• Appearance: /
• Density: 1.183 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.633
• CAS DataBase Reference: 1-BENZYL-3-HYDROXYMETHYL-1H-INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-3-HYDROXYMETHYL-1H-INDAZOLE(131427-21-9)
• EPA Substance Registry System: 1-BENZYL-3-HYDROXYMETHYL-1H-INDAZOLE(131427-21-9)

Safety Data

• Hazardous Substances Data: 131427-21-9(Hazardous Substances Data)

Usage

General Description

1-BENZYL-3-HYDROXYMETHYL-1H-INDAZOLE is a chemical compound with the molecular formula C16H15N2O. It is a benzyl derivative of 1H-indazole with a hydroxymethyl group attached to the 3-position. 1-BENZYL-3-HYDROXYMETHYL-1H-INDAZOLE has been studied for its potential pharmacological properties, including its potential as an anticancer agent. It has also been investigated for its potential use as a fluorescent probe for detecting metal ions. Additionally, 1-BENZYL-3-HYDROXYMETHYL-1H-INDAZOLE has been researched for its use in the development of new pharmaceuticals and other organic compounds.

InChI:InChI=1/C15H14N2O/c18-11-14-13-8-4-5-9-15(13)17(16-14)10-12-6-2-1-3-7-12/h1-9,18H,10-11H2

Upstream product

• 173600-03-8 benzyl-1H-indazole-3-carboxylic acid methyl ester 
• 100-39-0 benzyl bromide 
• 64132-13-4 3-(hydroxymethyl)-1H-indazole 
• 2142-69-0 2-bromophenyl methyl ketone 
• 1186509-61-4 1-benzyl-1H-indazole-3-carbaldehyde 
• 205643-28-3 N-benzyl-3-iodo-1H-indazole 
• 40598-94-5 3-bromo-1H-indazole 
• 50-00-0 formaldehyd 
• 29985-03-3 1-benzyl-3-bromoindazole 
• 7732-18-5 water 
• 174180-54-2 1-Benzyl-1H-indazole-3-carboxylic acid benzyl ester 
• 97-64-3 ethyl 2-hydroxypropionate 
• 131427-22-0 1-benzyl-3-chloromethyl-1H-indazole 
• 4498-67-3 1H-Indazole-3-carboxylic acid 

Downstream Products

• 1186507-37-8 [1-(4-methoxybenzyl)-1H-indazol-3-yl]methanol 
• 1186610-48-9 2-[(1-benzyl-1H-indazol-3-yl)methoxy]-N,N-dimethylethanamine 
• 1186509-61-4 1-benzyl-1H-indazole-3-carbaldehyde 
• 131427-22-0 1-benzyl-3-chloromethyl-1H-indazole 
• 130641-38-2 2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid 
• 174181-79-4 2-{3-[(1-benzyl-1H-indazol-3-yl)methyl]-3-methoxy-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl}-N-isopropyl-N-(4-methoxyphenyl)acetamide 
• 174180-56-4 2-[(1-benzyl-1H-indol-3-yl)methyl]-2-methoxypropanedioic acid dimethyl ester 
• 174180-40-6 2-[(1-benzyl-1H-indol-3-yl)methyl]-2-methoxypropanedioic acid 
• 1026501-94-9 2-(1-Benzyl-1H-indazol-3-ylmethyl)-2-methoxy-propanedioyl dichloride 
• 174180-33-7 1-Benzyl-3-bromomethyl-1H-indazole 

Relevant articles and documents

Preparation method of indazole and application of indazole in medicine synthesis

The invention belongs to the field of chemicals, and relates to a preparation method of indazole and an application of the indazole in medicine synthesis. The invention discloses a preparation method of indazole and an application of the indazole in synthesizing 1H-indazole-3-carboxylic acid, lonidamine, a compound 8, a compound 9, a compound 10, axitinib, YD-3, YC-1 and similar substances thereof.

PROCESS FOR THE PREPARATION OF 1-BENZYL-3-HYDROXYMETHYL- 1H- INDAZOLE AND ITS DERIVATIVES AND REQUIRED MAGNESIUM INTERMEDIATES

The present invention relates to the process for the conversion of 1-benzyl-3-hydroxymethyl-1H-indazole according to formula (II), to the 1-benzyl-3-hydroxymethyl-1H-indazole according to formula (I).

NOVEL 1-BENZIL-3-HYDROXYMETHYLINDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1, CX3CR1 AND P40

The present invention relates to novel 1-benzyl-3-hydroxymethylindazole derivatives according to Formula (I) described in the claims, and to a pharmaceutical composition comprising them, together with a pharmaceutically acceptable vehicle. In addition, the present invention relates to the use of 1-benzyl-3-hydroxymethylindazole derivatives for the preparation of a pharmaceutical composition that is active in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40, and to their use in a method for treating or preventing diseases based on the expression of MCP-1, CX3CR1 and p40.