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(R)-(4-Fluorophenyl)oxirane is an organic compound that features a chiral oxirane ring attached to a 4-fluorophenyl group. It is a versatile intermediate in the synthesis of various pharmaceuticals and agrochemicals due to its unique structural features and reactivity.

134356-73-3

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134356-73-3 Usage

Uses

Used in Pharmaceutical Industry:
(R)-(4-Fluorophenyl)oxirane is used as a pharmaceutical intermediate for the synthesis of various drugs and therapeutic agents. Its unique structure allows for the development of new compounds with improved pharmacological properties and selectivity.
Used in Agrochemical Industry:
(R)-(4-Fluorophenyl)oxirane is also used as an intermediate in the production of agrochemicals, such as pesticides and herbicides. Its reactivity and structural features enable the creation of novel compounds with enhanced efficacy and selectivity in controlling pests and weeds.
Used in Benzoylthiophenes Synthesis:
(R)-(4-Fluorophenyl)oxirane is used as a key intermediate in the synthesis of benzoylthiophenes, which are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor. This application highlights its importance in the development of new drugs targeting the A1 adenosine receptor for various therapeutic purposes.

Check Digit Verification of cas no

The CAS Registry Mumber 134356-73-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,3,5 and 6 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 134356-73:
(8*1)+(7*3)+(6*4)+(5*3)+(4*5)+(3*6)+(2*7)+(1*3)=123
123 % 10 = 3
So 134356-73-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H7FO/c9-7-3-1-6(2-4-7)8-5-10-8/h1-4,8H,5H2/t8-/m0/s1

134356-73-3 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
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  • Detail
  • Alfa Aesar

  • (H33603)  (R)-(-)-4-Fluorostyrene oxide, 98+%, ee 98+%   

  • 134356-73-3

  • 1g

  • 1088.0CNY

  • Detail
  • Alfa Aesar

  • (H33603)  (R)-(-)-4-Fluorostyrene oxide, 98+%, ee 98+%   

  • 134356-73-3

  • 5g

  • 4469.0CNY

  • Detail
  • Aldrich

  • (41609)  (R)-(4-Fluorophenyl)oxirane  technical, ≥90.0% (GC)

  • 134356-73-3

  • 41609-250MG

  • 1,627.47CNY

  • Detail
  • Aldrich

  • (41609)  (R)-(4-Fluorophenyl)oxirane  technical, ≥90.0% (GC)

  • 134356-73-3

  • 41609-1G

  • 2,853.63CNY

  • Detail

134356-73-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name (2R)-2-(4-fluorophenyl)oxirane

1.2 Other means of identification

Product number -
Other names 4-F-styrene oxide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:134356-73-3 SDS

134356-73-3Relevant academic research and scientific papers

Synthesis, Crystal Structures, and Catalytic Oxidation of Olefins of Novel Oxomolybdenum(VI) Clusters

Peng

, p. 457 - 466 (2019)

Abstract: Two Mo(VI) clusters, (H2L)3[Mo7O12(μ2-O)8(μ3-O)4] · 3H2O (I) and (H2L)2[Mo8O14(μ2-O)6

Low Temperature Asymmetric Epoxidation of Unfunctionalized Olefins Catalyzed by (Salen)Mn(III) Complexes

Palucki, Michael,McCormick, Gregory J.,Jacobsen, Eric N.

, p. 5457 - 5460 (1995)

The enantioselective epoxidation of olefins catalyzed by (salen)Mn(III) complexes can be effected under anhydrous conditions with a variety of primary oxidant system.The combination of m-CPBA and NMO is particularly reactive, allowing for epoxidation reac

Iron-Decorated, Guanidine Functionalized Metal-Organic Framework as a Non-heme Iron-Based Enzyme Mimic System for Catalytic Oxidation of Organic Substrates

Shaabani, Ahmad,Mohammadian, Reza,Farhid, Hassan,Karimi Alavijeh, Masoumeh,Amini, Mostafa M.

, p. 1237 - 1249 (2019)

A novel porous functionalized metal-organic framework (MOF) as a non-heme iron-based enzyme mimic system was achieved via two-step post-synthetic modification of the MIL-101(Cr)-NH2, and characterized by FT-IR, PXRD, TGA, SEM, EDS, CHN, BET surface area, and ICP-OES analyses. This new modified MOF (MIL-101(Cr)-guanidine-Fe) has been demonstrated to be a highly efficient, active, and reusable catalyst for oxidation of various organic substrates, including alcohols, alkenes and alkyl arenes at room temperature using H2O2 as an oxidant. Graphical Abstract: [Figure not available: see fulltext.].

A FIRST NON-STABILIZED TELLURONIUM YLIDE - DIPHENYLTELLURONIUM METHYLIDE AS A NOVEL REAGENT FOR SYNTHESIS OF OXIRANES

Shi, Li-Lan,Zhou, Zhang-Lin,Huang, Yao-Zeng

, p. 4173 - 4174 (1990)

Diphenyltelluronium methylide, generated from methyldiphenyltelluronium tetraphenylborate 1 with LiTMP, reacted with carbonyl compounds to afford substituted oxiranes in moderate to good yields.

Enhanced turnover rate and enantioselectivity in the asymmetric epoxidation of styrene by new T213G mutants of CYP 119

Zhang, Chun,Li, Jing,Yang, Bo,He, Fang,Yang, Sheng-Yong,Yu, Xiao-Qi,Wang, Qin

, p. 27526 - 27531 (2014)

New CYP 119 T213G mutants were constructed and characterized. Introduction of the T213G mutation into the wild-type CYP 119 significantly enhances the turnover rate for the peroxide-dependent styrene epoxidation 4.4-fold to 346.2 min-1, and the

A highly efficient heterogeneous catalyst of bimetal-organic frameworks for the epoxidation of olefin with H2O2

Huang, Hong,Lv, Jing,Meng, Xiang-Guang,Wang, Fei,Wu, Yan-Yan,Yu, Wen-Wang

, (2020)

A series of bimetel organic framework MnxCu1?x-MOF were prepared. The MOFs was characterized and analyzed by powder X-ray diffraction (PXRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), and transmissio

Facile access to α-acyloxyamides via epoxide rearrangement/three-component domino reaction catalyzed by indium(III) chloride

Lingaswamy, Kadari,Krishna, Palakodety Radha,Prapurna, Y. Lakshmi

, p. 1275 - 1282 (2016)

A simple and efficient Passerini reaction of epoxides involving highly regioselective rearrangement of epoxide to aldehyde/three-component Passerini reaction catalyzed by indium(III) chloride is described. In the present protocol, epoxides served as wonderful substrates to furnish a library of α-acyloxyamides under mild reaction conditions in shorter reaction times and in good yields.

Benzodiazepine analogues. Part 15. Synthesis of benzoxathiepine derivatives

Gelebe, Aifheli C.,Kaye, Perry T.

, p. 4459 - 4475 (1996)

Stepwise cyclisation sequences have provided access to a series of novel 4-phenyl-3,4-dihydro-1,5-benzoxathiepine-2-ones and 2- and 3-phenyl-4,1-benzoxathiepine analogues.

Chiral Separation of Styrene Oxides Supported by Enantiomeric Tetrahedral Neutral Pd(II) Cages

Rajasekar, Prabhakaran,Pandey, Swechchha,Ferrara, Joseph D.,Del Campo, Mark,Le Magueres, Pierre,Boomishankar, Ramamoorthy

, (2019)

The separation of enantiomers is of considerable importance in the preparation of the compounds of biological interests, catalysis, and drug development. Here, we report a novel enantioseparation of styrene epoxides (SOs) resolved in the presence of a pair of enantio-enriched tetrahedral cages. Chiral neutral cages of formula [(Pd3X*)4(C6O4Cl2)6] ([X*]3- = RRR- or SSS-[PO(N(*CH(CH3)Ph)3]3-) are constructed from Pd3 building units supported by tris(imido)phosphate trianions and chloranilate linkers. These cages exhibit considerable enantioselective separation capabilities toward a series of styrene epoxides via a crystallization inclusion method. A highest enantiomeric excess (ee) value of up to 80% is achieved for the (R)-4-fluorostyrene oxide.

Tri-Manganese(III) Salen-Based Cryptands: A Metal Cooperative Antioxidant Strategy that Overcomes Ischemic Stroke Damage in Vivo

Du, Yujing,Gao, Song,Huo, Yan,Jiang, Shang-Da,Kang, Lei,Li, Cuicui,Lin, Hengyu,Ning, Yingying,Sedgwick, Adam C.,Sessler, Jonathan L.,Wang, Bing-Wu,Xue, Haozong,Yao, Yuhang,Zhang, Jun-Long

, p. 10219 - 10227 (2020)

Oxidative stress is one of the hallmarks of ischemic stroke. Catalase-based (CAT) biomimetic complexes are emerging as promising therapeutic candidates that are expected to act as neuroprotectants for ischemic stroke by decreasing the damaging effects fro

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