135262-85-0

Basic information

• Product Name: Carbamic acid, 3-cyclohexen-1-yl-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, 3-cyclohexen-1-yl-, 1,1-dimethylethyl ester (9CI);Cyclohex-3-enyl-carbaMic acid tert-butyl ester;CarbaMic acid, N-3-cyclohexen-1-yl-, 1,1-diMethylethyl ester;N-Boc-cyclohex-3-enaMine;tert-Butyl cyclohex-3-en-1-ylcarbamate
• CAS NO: 135262-85-0
• Molecular Formula: C₁₁H₁₉NO₂
• Molecular Weight: 197.27406
• Product Categories: N-BOC
• Mol File: 135262-85-0.mol
• Article Data: 15

Chemical Properties

• Melting Point: 52-54 °C
• Boiling Point: 288.2±20.0 °C(Predicted)
• Appearance: /
• Density: 1.00±0.1 g/cm3(Predicted)
• PKA: 12.43±0.20(Predicted)
• CAS DataBase Reference: Carbamic acid, 3-cyclohexen-1-yl-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, 3-cyclohexen-1-yl-, 1,1-dimethylethyl ester (9CI)(135262-85-0)
• EPA Substance Registry System: Carbamic acid, 3-cyclohexen-1-yl-, 1,1-dimethylethyl ester (9CI)(135262-85-0)

Safety Data

• Hazardous Substances Data: 135262-85-0(Hazardous Substances Data)

Usage

General Description

Carbamic acid, 3-cyclohexen-1-yl-, 1,1-dimethylethyl ester (9CI) is a chemical compound with the molecular formula C9H15NO2. It is a b-estradiol derivative and is classified as a tretinoin-class compound. This chemical is most commonly used in the pharmaceutical industry as an intermediate for the synthesis of various medications, particularly those used in the treatment of cancer and other serious medical conditions. 1,1-dimethylethyl ester (9CI) is also considered to be a potential teratogen, which means it may cause developmental abnormalities in fetuses. Additionally, it is important to handle and store this compound with proper safety precautions as it is known to be hazardous if not handled properly.

Upstream product

• 77626-69-8 cyclohex-3-enecarboxylic acid allyl ester 
• 75-65-0 tert-butyl alcohol 
• 4771-80-6 1,2,5,6-tetrahydrobenzoic acid 
• 4129-17-3 diphenylphosphoranyl azide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 27489-62-9 trans-4-hydroxycyclohexylamine 
• 111300-06-2 trans-tert-butyl 4-hydroxycyclohexylcarbamate 
• 124-63-0 methanesulfonyl chloride 
• 1204401-31-9 tert-butyl cis-4-(iodo)cyclohexylcarbamate 
• 130309-46-5 trans-4-(tert-butoxycarbonylamino)cyclohexane carboxylic acid 
• 72581-32-9 cyclohex-3-enylmethanol 
• 4103-88-2 1-isocyano-3-cyclohexene 
• 4248-19-5 tert-butyl carbazate 
• 2100-17-6 4-pentenal 

Downstream Products

• 1195100-55-0 tert-butyl (6-chloropyridin-3-yl)methyl(cyclohex-3-enyl)carbamate 
• 422507-09-3 4-[N-benzyl-N-(tert-butoxycarbonyl)amino]cyclohex-1-ene 
• 1061341-34-1 tert-butyl allyl(cyclohex-3-enyl)carbamate 
• 22615-33-4 cyclohex-3-en-1-ylamine hydrochloride 
• 1061338-33-7 N-Ethyl-N-(cyclohex-3-enyl)-carbamic acid tert-butyl ester 
• 836607-81-9 (1RS,2SR,4SR)-2-bromo-7-azabicyclo[2.2.1]heptane 

Relevant articles and documents

Merging Halogen-Atom Transfer (XAT) and Cobalt Catalysis to Override E2-Selectivity in the Elimination of Alkyl Halides: A Mild Route towardcontra-Thermodynamic Olefins

We report here a mechanistically distinct tactic to carry E2-type eliminations on alkyl halides. This strategy exploits the interplay of α-aminoalkyl radical-mediated halogen-atom transfer (XAT) with desaturative cobalt catalysis. The methodology is high-yielding, tolerates many functionalities, and was used to access industrially relevant materials. In contrast to thermal E2 eliminations where unsymmetrical substrates give regioisomeric mixtures, this approach enables, by fine-tuning of the electronic and steric properties of the cobalt catalyst, to obtain high olefin positional selectivity. This unprecedented mechanistic feature has allowed access tocontra-thermodynamic olefins, elusive by E2 eliminations.

Preparation method of beta-homoglutamic acid

The invention belongs to the field of preparation of organic compounds, and provides a preparation method of beta-homoglutamic acid. The method is characterized in that: 3-cyclohexenecarboxylic acid is used as a raw material, beta-homoglutamic acid is synthesized at a high yield through three the steps of reactions of Curtius rearrangement, olefin oxidation and protection group removal, and beta-homoglutamic acid with high yield and high optical purity can be obtained through configuration retention by using optically pure 3-cyclohexenecarboxylic acid. The method has the advantages of easily available raw materials, mild reaction conditions and low cost, and is suitable for large-scale preparation of beta-homoglutamic acid.

Palladium- and ruthenium-catalyzed cycloisomerization of enynamides and enynhydrazides: A rapid approach to diverse azacyclic frameworks

I want to ride my azacycle: The title reaction of enynamides affords a wide diversity of azacycles. The reactions are high-yielding, highly stereoselective, and proceed rapidly under mild reaction conditions. Equivalent transformations using enynhydrazides offer new routes to pyrazole and indazole scaffolds. Boc=tert-butoxycarbonyl, EWG=electron-withdrawing group, Ns=4-nitrobenzenesulfonyl, Ts=4-toluenesulfonyl. Copyright