14062-22-7

Upstream product

• 64-17-5 ethanol 
• 32857-63-9 4-t-butylphenylacetic acid 
• 50-00-0 formaldehyd 
• 253185-03-4 tert-butylbenzene 
• 143-33-9 sodium cyanide 
• 26537-19-9 methyl 4-tert-butylbenzoate 
• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 
• 943-27-1 4'-t-butylacetophenone 
• 3288-99-1 4-tert-butylbenzyl cyanide 
• 7664-93-9 sulfuric acid 
• 105-36-2 ethyl bromoacetate 
• 123324-71-0 p-tert-butylphenylboronic acid 
• 3972-56-3 4-(tert-butyl)chlorobenzene 
• 5764-82-9 bromo(2-ethoxy-2-oxoethyl)zinc 

Downstream Products

• 94959-58-7 diethyl α-(4-tert-butylphenyl)malonate 
• 43074-77-7 6-(4-tert-butyl-benzyl)-N-cyclohexyl-[1,3,5]triazine-2,4-diamine 
• 1375102-88-7 C₂₇H₃₈FN₃O₄S₂ 
• 1375102-81-0 C₁₈H₂₈O₃ 
• 1375102-83-2 C₁₈H₂₇N₃O₂ 
• 1375102-85-4 C₁₉H₂₇NO₂S 
• 115169-49-8 2-(4-tert-butylphenyl)propane-1,3-diol 
• 1375102-92-3 C₁₉H₃₀O₅S 
• 1375102-86-5 C₂₇H₃₉N₃O₄S₂ 
• 1439386-58-9 1-(4-(tert-butyl)benzyl)cyclopropanol 
• 1379525-71-9 1,4-bis(4-bromophenyl)-3,6-bis(4-tert-butylphenyl)pyrrolo[3,2-b]-pyrrole-2,5-dione 
• 1026245-10-2 (Z)-2-(4-tert-Butyl-phenyl)-3-{2-[(Z)-2-(4-tert-butyl-phenyl)-2-ethoxycarbonyl-vinylamino]-phenylamino}-acrylic acid ethyl ester 
• 208054-08-4 3,8-Bis-(4-tert-butyl-phenyl)-1,10-dihydro-[1,10]phenanthroline-4,7-dione 
• 208054-04-0 (Z)-ethyl 2-(4-(tert-butyl)phenyl)-3-hydroxyacrylate 

Relevant academic research and scientific papers

Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters

We have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up to 1560 and are smoothly conducted by the usage of a low catalyst loading, a new available ligand, and a green solvent. A variety of functional groups are tolerated, and the application occurs with α-aryl-esters to access nonsteroidal anti-inflammatory drugs (NSAIDs) on the gram scale.

Coupling of Reformatsky Reagents with Aryl Chlorides Enabled by Ylide-Functionalized Phosphine Ligands

The coupling of aryl chlorides with Reformatsky reagents is a desirable strategy for the construction of α-aryl esters but has so far been substantially limited in the substrate scope due to many challenges posed by various possible side reactions. This limitation has now been overcome by the tailoring of ylide-functionalized phosphines to fit the requirements of Negishi couplings. Record-setting activities were achieved in palladium-catalyzed arylations of organozinc reagents with aryl electrophiles using a cyclohexyl-YPhos ligand bearing an ortho-tolyl-substituent in the backbone. This highly electron-rich, bulky ligand enables the use of aryl chlorides in room temperature couplings of Reformatsky reagents. The reaction scope covers diversely functionalized arylacetic and arylpropionic acid derivatives. Aryl bromides and chlorides can be converted selectively over triflate electrophiles, which permits consecutive coupling strategies.

Exploiting the trifluoroethyl group as a precatalyst ligand in nickel-catalyzed Suzuki-type alkylations

We report herein the exploitment of the partially fluorinated trifluoroethyl as precatalyst ligands in nickel-catalyzed Suzuki-type alkylation and fluoroalkylation coupling reactions. Compared with the [LnNiII(aryl)(X)] precatalysts, the unique characters of bis-trifluoroethyl ligands imparted precatalyst [(bipy)Ni(CH2CF3)2] with bench-top stability, good solubilities in organic media and interesting catalytic activities. Preliminary mechanistic studies reveal that an eliminative extrusion of a vinylidene difluoride (VDF, CH2CF2) mask from [(bipy)Ni(CH2CF3)2] is a critical step for the initiation of a catalytic reaction.

Graphene Oxide: An Efficient Acid Catalyst for the Construction of Esters from Acids and Alcohols

Graphene oxide was found to be an efficient and reusable acid catalyst for the esterification reaction. A wide range of aliphatic and aromatic acids and alcohols were compatible with the standard conditions and afforded the corresponding products in good yields. The heterogeneous catalyst can be easily recovered and recycled in dichloro-ethane solvent with good catalytic activity.

Iron and manganese catalysts for the selective functionalization of arene C(sp2)-H bonds by carbene insertion

The first examples of the direct functionalization of non-activated aryl sp2 C-H bonds with ethyl diazoacetate (N2CHCO2Et) catalyzed by Mn- or Fe-based complexes in a completely selective manner are reported, with no formation of the frequently observed cycloheptatriene derivatives through competing Buchner reaction. The best catalysts are FeII or MnII complexes bearing the tetradentate pytacn ligand (pytacn= 1-(2-pyridylmethyl)-4,7-dimethyl-1,4,7-triazacyclononane). When using alkylbenzenes, the alkylic C(sp3)-H bonds of the substituents remained unmodified, thus the reaction being also selective toward functionalization of sp2 C-H bonds. Exclusive catalysis: Iron- and-manganese-based catalysts selectively functionalize the C(sp2)-H bonds of benzene or alkylbenzenes through the formal insertion of the CHCO2Et group from N2CHCO2Et (see scheme). When using alkylbenzenes, the alkylic C(sp3)-H bonds of the substituents remain unmodified.

Water works: An efficient palladium-catalyzed cross-coupling reaction between boronic acids and bromoacetate with aminophosphine ligand

Water greatly restrained the formation of self-coupling of boronic acids in a palladium-catalyzed cross-coupling reaction between boronic acids and ethyl bromoacetate with an aminophosphine ligand; good to excellent yields of cross-coupling product were obtained.

N-disubstituted cycloalkylmethyl amines useful as fungicides

Compounds having plant fungicidal properties are of formula: and stereoisomers thereof, wherein R1 and R2, each represent a hydrogen atom, a halogen atom, or an alkyl group containing from 1 to 4 carbon atoms, R3 and Rsub